Results 11 to 20 of about 11,791 (282)

New Methods for the Synthesis of Spirocyclic Cephalosporin Analogues

Molecules, 2021
Spiro compounds provide attractive targets in drug discovery due to their inherent three-dimensional structures, which enhance protein interactions, aid solubility and facilitate molecular modelling.
Alan X. Zhao, Louise E. Horsfall, Alison N. Hulme   +2 more
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Spiro-Flavonoids in Nature: A Critical Review of Structural Diversity and Bioactivity

Molecules, 2023
Based on the literature data from 1973 to 2022, this work summarizes reports on spiro-flavonoids with a spiro-carbon at the center of their structure and how this affects their isolation methods, stereochemistry, and biological activity.
Łukasz Pecio, Solomiia Pecio, Tomasz Mroczek, Wiesław Oleszek   +3 more
doaj   +1 more source

Synthesis, antimicrobial activity and molecular docking studies of spiroquinoline-indoline-dione and spiropyrazolo-indoline-dione derivatives

Scientific Reports, 2023
Spiro[benzo[h]quinoline-7,3′-indoline]diones and spiro[indoline-3,4′-pyrazolo[3,4-b]quinoline]diones were efficiently synthesized via one-pot multi-component reactions under ultrasound-promoted conditions.
Melek Gul, Emine Turk Celikoglu, Onder Idil, Gamze Tas, Emel Pelit   +4 more
doaj   +1 more source

An Efficient Synthesis and Antibacterial Activity of Some Novel 3,4–Dihydropyrimidin-2-(1H)-Ones

Chemistry Proceedings, 2021
We have efficiently synthesized mono as well as bis and spiro cyclic products of 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) by refluxing a reaction mixture of the three components in deep eutectic solvent (DES) to generating “libraries from libraries ...
Nilesh S. Pawar, Pramod N. Patil, Rajashri N. Pachpande   +2 more
doaj   +1 more source

Furan-Containing Chiral Spiro-Fused Polycyclic Aromatic Compounds: Synthesis and Photophysical Properties

Molecules, 2022
Spiro-fused polycyclic aromatic compounds (PACs) have received growing interest as rigid chiral scaffolds. However, furan-containing spiro-fused PACs have been quite limited.
Koji Nakano, Ko Takase, Keiichi Noguchi
doaj   +1 more source

Synthesis and Characterization of a Three Rings Heterocyclic Spiro Furan and Evaluation of its Cytotoxicity Properties on G-292 Cell Lines [PDF]

شیمی کاربردی روز, 2021
Synthesis and study of the medicinal properties of new spiro compounds with various functional groups is of great interest to organic and pharmaceutical researchers because of their special structure and conformation. Multi-component reactions are one of
Mona Besharat, Samira Arab-Salmanabadi, Omid Moradi   +2 more
doaj   +1 more source

Synthesis and Characterization of New Spiroheterocyclic from Isatin and Evaluation of Some Their Antifungal and Antibacterial Activity [PDF]

مجلة جامعة الانبار للعلوم الصرفة
Spiro compounds Spiro cycles are widely found in natural products, medicines, and functional materials[1] the spiro atom forces the planes of the two rings to almost face one another, spiro compounds are a desirable subclass of heterocyclic scaffolds. In
Zubaida Al-Heety, Ali Al-Nasseri
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New 6′-Amino-5′-cyano-2-oxo-1,2-dihydro-1′H-spiro[indole-3,4′-pyridine]-3′-carboxamides: Synthesis, Reactions, Molecular Docking Studies and Biological Activity

Molecules, 2023
The purpose of this work was to prepare new isatin- and monothiomalondiamide-based indole derivatives, as well as to study the properties of the new compounds.
Victor V. Dotsenko, Nawras T. Jassim, Azamat Z. Temerdashev, Zainab R. Abdul-Hussein, Nicolai A. Aksenov, Inna V. Aksenova   +5 more
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Multicomponent synthesis, biological evaluation and molecular docking of new spiro-oxindole derivatives

Journal of Taibah University for Science, 2017
A new series of spiro-oxindoles that were identified based upon their ability to inhibit methionine tRNA synthase (PDB ID: 1PFV) and glucosamine-6-phosphate synthase (PDB ID: 1JXA) enzymes in virtual screening was synthesized by a three-component 1,3 ...
M. Sapnakumari, B. Narayana, K.S. Shashidhara, B.K. Sarojini   +3 more
doaj   +1 more source

Microwave Assisted Synthesis of Some New Heterocyclic Spiro-Derivatives with Potential Antimicrobial and Antioxidant Activity

Molecules, 2010
Homophthalic anhydride reacts with different aromatic amines to produce N-substituted homophthalimides. Bromination of the latter produces 4,4-dibromo-homophthalimide derivatives that can be used as precursors for spiro-derivatives.
Mohamed Mohamed Youssef, Mahmoud Ahmed Amin   +1 more
doaj   +1 more source