Results 191 to 200 of about 3,124 (225)

Enantioselective Construction of Spirooxindole-Fused Cyclopentanes [PDF]

The Journal of Organic Chemistry, 2021
The present study reports an asymmetric organocatalytic cascade reaction of oxindole derivates with α,β-unsaturated aldehydes efficiently catalyzed by simple chiral secondary amine. Spirooxindole-fused cyclopentanes were produced in excellent isolated yields (up to 98%) with excellent enantiopurities (up to 99% ee) and moderate to high ...
Vojtěch Dočekal, Andrea Vopálenská, Pavel Měrka, Klára Konečná, Ondřej Jand’ourek, Milan Pour, Ivana Císařová, Jan Veselý   +7 more
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Expeditious entry into carbocyclic and heterocyclic spirooxindoles

Organic & Biomolecular Chemistry, 2022
Recent advances in the chemistry of base-, metal-, nano-metal and organo-catalyst mediated achiral and chiral versions of the structurally diverse and pharmaceutically relevant spirooxindoles are gently reviewed.
Madhu Ganesh, Shammy Suraj
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Organocatalytic Asymmetric Synthesis of Spirooxindole Embedded Oxazolidines [PDF]

The Journal of Organic Chemistry, 2021
The first organocatalytic asymmetric synthesis of spirooxindole embedded oxazolidines has been developed via a domino reaction involving hemiaminal formation, followed by an unprecedented aza-Michael reaction between isatin derived N-Boc ketimines and γ-hydroxy enones.
Chandrakanta Parida, Buddhadeb Mondal, Animesh Ghosh, Subhas Chandra Pan   +3 more
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ChemInform Abstract: A New Route to Spirooxindoles.

ChemInform, 2000
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Tim C. T. Ho, Goran Pljevaljcic, Stephen T. Hilton, Keith Jones   +3 more
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ChemInform Abstract: Strategies for the Enantioselective Synthesis of Spirooxindoles.

ChemInform, 2012
AbstractReview: 85 refs.
Nicolas R. Ball-Jones, Annaliese K. Franz, Joseph J. Badillo   +2 more
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An Access to Highly Functionalized Dihydrobenzofuran Spirooxindole Scaffolds

Organic Letters, 2022
We have developed an efficient protocol for the construction of polycyclic dihydrobenzofuran spirooxindole scaffolds via base promoted cascade annulation of Morita-Baylis-Hillman (MBH) carbonates of isatins with ortho-hydroxychalcones or ortho-hydroxy-β-nitrostyrenes. The complex polycyclic compounds were conveniently synthesized in satisfactory yields
Daqian Wang, Jing Sun, Ying Han, Qiu Sun, Chao-Guo Yan   +4 more
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ChemInform Abstract: Spirooxindoles: Promising Scaffolds for Anticancer Agents

ChemInform, 2015
AbstractReview: 84 refs.
Bin Yu, Hong-Min Liu, De-Quan Yu
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Catalytic asymmetric synthesis of spirooxindoles: recent developments

Chemical Communications, 2018
The past four years have witnessed significant developments in the field of the catalytic asymmetric synthesis of spirooxindoles, and this feature article outlines the recent progress in this area, including the contributions of our group. This article is divided into sections according to the size and type of the generated spiro-ring fused at the C3 ...
Guang-Jian Mei, Feng Shi
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Recent Strategies in the Synthesis of Spiroindole and Spirooxindole Scaffolds

Topics in Current Chemistry, 2021
Spiroindole and spirooxindole scaffolds are very important spiro-heterocyclic compounds in drug design processes. Significant attention has been directed at obtaining molecules based on spiroindole and spirooxindole derivatives that have bioactivity against cancer cells, microbes, and different types of disease affecting the human body.
Shima Nasri, Mohammad Bayat, Faezeh Mirzaei   +2 more
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Spirooxindoles as Potential Pharmacophores

Mini-Reviews in Medicinal Chemistry, 2017
The spiroindole heterocyclic scaffold is found in many natural products and has been identified as an important bioactive agent. Over the past few decades, various spiroindole-containing compounds have been reported to possess biological properties and hence found in the structure of many synthetic pharmaceuticals.
Rachel A. Jones, Siva S. Panda, Praveen Bachawala, Prabhu P. Mohapatra   +3 more
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