Results 201 to 210 of about 3,124 (225)

Molecular diversity of spirooxindoles. Synthesis and biological activity

Molecular Diversity, 2015
Spirooxindoles are important synthetic targets possessing extended biological activity and drug discovery applications. This review focuses on the various strategies for the enantioselective synthesis of spirocyclic oxindoles relying on reports over the past decade and from earlier work.
Victoria V. Lipson, Victoria V. Lipson, Tetyana L. Pavlovska, R. G. Red’kin, Dmytro V. Atamanuk   +4 more
openaire   +3 more sources

Synthesis of Spirooxindoles via the tert-Amino Effect

Organic Letters, 2017
A new method is developed for the synthesis of spirooxindoles from amines and isatins via C-H functionalization. The reaction leverages the tert-amino effect to form an enolate-iminium intermediate via [1,5]-hydride shift followed by cyclization. Interestingly the hydride migrates to the N atom of a C═N, which is atypical for hydride additions to ...
Kinthada Ramakumar, Tapan Maji, James J. Partridge, Jon A. Tunge   +3 more
openaire   +3 more sources

ChemInform Abstract: Titanium‐Catalyzed Stereoselective Synthesis of Spirooxindole Oxazolines.

ChemInform, 2010
AbstractReaction of various isatins with 5‐methoxyoxazoles proceeds regioselectively and with high diastereoselectivity to afford spiro products (III) and (V).
James C. Fettinger, Annaliese K. Franz, Gary E. Arevalo, Joseph J. Badillo   +3 more
openaire   +4 more sources

Organocatalytic Approach to Spirooxindoles [PDF]

Synfacts, 2020
Paul Richardson, Victor Snieckus
openaire   +1 more source

Selective Synthesis of Spirooxindoles by an Intramolecular Heck–Mizoroki Reaction

Organic Letters, 2017
We report a highly diastereoselective synthesis of cyclopentene-spirooxindole derivatives via an intramolecular Heck-Mizoroki reaction using aryl bromides as precursors. The reactions were performed under dry conditions or in a DMF-water system.
Tamal Roy, Peter Brandt, Alexander Wetzel, Joakim Bergman, Jonas Brånalt, Jonas Sävmarker, Mats Larhed   +6 more
openaire   +3 more sources

ChemInform Abstract: A General and Efficient Method to Access Tetracyclic Spirooxindole Derivatives.

ChemInform, 2014
AbstractAn efficient, simple, and convenient synthetic procedure for the synthesis of tetracyclic spirooxindole derivatives, starting from N‐protected isatins and 2‐fluoropyridine, was successfully developed. It enables the facile formation of a new class of spirooxindoles in which the oxindole core is fused with various heterocycles at the C‐3 ...
Bouakher, Abderrahman El, Massip, Stéphane, Jarry, Christian, Troin, Yves, Abrunhosa-Thomas, Isabelle, Guillaumet, Gérald   +5 more
openaire   +5 more sources

Superacid-Promoted synthesis of spirooxindoles

Tetrahedron Letters, 2023
Jacob C. Hood, Hien Vuong, Douglas A. Klumpp   +2 more
openaire   +1 more source

Synthesis of novel spirooxindole-pyrrolidines and evaluation of their cytotoxic activity

Pharmacological Reports, 2019
A variety of spirooxindoles have demonstrated cytotoxic activity toward several cancer cell lines. This study investigates the cytotoxicity of five novel spirooxindole-pyrrolidines by using the Vero and HeLa cell lines.Vero and HeLa cells were treated with the synthesized spirooxindoles, and the cytotoxicity was evaluated by using the AlamarBlue Cell ...
A. A. Anis’kov, Iraida Nikolaevna Klochkova, Gennady L. Burygin, Roman S. Tumskiy, Roman S. Tumskiy   +4 more
openaire   +3 more sources

Enantioselective Synthesis of Pentacyclic Spirooxindoles [PDF]

Synfacts, 2019
Victor Snieckus, Paul Richardson
openaire   +1 more source

Asymmetric Synthesis of Spirooxindoles

Synfacts, 2011
R. Wang, X. Jiang, Luping Liu, F. Zhang, Y. Cao, F. Shen   +5 more
openaire   +2 more sources