Results 171 to 180 of about 58,017 (329)

Proteogenomic Characterization Reveals Metabolic Vulnerabilities and Aberrant Phosphorylation in Colorectal Metastasis to Liver

Advanced Science, Volume 13, Issue 4, 19 January 2026.
This study provides a multi‐omics landscape of treatment‐naïve colorectal liver metastasis and reveals dysregulated molecules and cellular pathways. SHMT1 and NDRG1 Ser330 phosphorylation are demonstrated to display crucial roles in tumorigenesis and liver metastasis. Two proteomics subtypes (metabolism and RNA function) with distinct clinical outcomes
Wensi Zhao, Lei Zhao, Yannan Lian, Zhiwei Liu, Yaqi Li, Xuege Wang, Mingya Zhang, Ni Li, Jingli Guo, Danqing Shen, Shaobo Mo, Jiahao Li, Linhui Zhai, Jiahui Ni, Sangkyu Lee, Bin Liu, Jing Li, Fei Wang, Junjie Peng, Jun Qin, Minjia Tan   +20 more
wiley   +1 more source

Exploring the Role of Long Noncoding RNAs in Breast Cancer Progression: A Comprehensive Study on Biomarkers and Therapeutic Approaches

Cancer Medicine, Volume 15, Issue 1, January 2026.
ABSTRACT Background Among the many forms of cancer that plague women all over the globe, breast cancer (BC) is one of the most prevalent kinds. BC is a multifaceted disease that can manifest in many ways depending on the individual. Aims The identification of new biomarkers that may be used to diagnose and prognosis of the BC, as well as those that can
Ramin Moeini, Amin AhsanAlkhat, Saeid Ghorbian   +2 more
wiley   +1 more source

Characterization of chromosome 5 aberrations in TP53 mutated myeloid neoplasms with ≥5% blasts: An International TP53 Investigators Network (iTiN) study

Cancer, Volume 132, Issue 1, 1 January 2026.
ABSTRACT Background Isolated chromosome 5/5q losses (–5/5q) without TP53 mutations are associated with favorable outcomes in myeloid neoplasms (MN) with <5% blasts. However, the clinical implication of concurrent −5/5q and TP53 aberrations in MN with ≥5% blasts is poorly understood.
Irfan Yasin, Anna Stengel, Haipeng Shao, Amandeep Kaur, Emily F. Mason, Pranav P. Patwardhan, Nathanael G. Bailey, Sharmila Ghosh, Kedar V. Inamdar, Anand A. Patel, Madhavi Pandiri, Jingjing Zhang, Payal Sojitra, Hamza Tariq, Zenggang Pan, Danica Wiredja, Peng Wang, Melissa Y. Tjota, Jeremy P. Segal, Hong Chang, David A. Sallman, Daniel A. Arber, Ayalew Tefferi, Talha Badar, Anamarija M. Perry, Claudia Haferlach, Angela M. Lager, Girish Venkataraman   +27 more
wiley   +1 more source

Spliceosome [PDF]

Science-Business eXchange, 2009
openaire   +2 more sources

The Spliceosome: Design Principles of a Dynamic RNP Machine

Cell, 2009
M. Wahl, C. Will, R. Lührmann
semanticscholar   +1 more source

Spliceosomal Factor SmF Modulates Temperature‐Mediated Flower and Leaf Size Plasticity in Arabidopsis thaliana

Plant, Cell &Environment, EarlyView.
Gregory M. Andreou‐Huotari, Mikael Brosché, Jan Hoffmann, Zoran Nikoloski, Roosa A. E. Laitinen   +4 more
wiley   +1 more source

Identification of Potential Ferroptosis Biomarkers in Multiple Myeloma via WGCNA and Experiments

Cancer Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Introduction Multiple myeloma is a common malignant tumor of the hematologic system, and genetic alterations play a crucial role in its occurrence and development. Ferroptosis is an oxidative and iron‐dependent programmed cell death, which has a strong correlation with tumor development.
Yifan Wang, Xing Xie, Mengyuan Gu, Yanting Zheng, Jing Wu, Qicai Wang, Zhian Ling, Ruolin Li   +7 more
wiley   +1 more source

Proteome and Phosphoproteome Profiling Reveal the Toxic Mechanism of Clostridium perfringens Epsilon Toxin in MDCK Cells

Toxins
Epsilon toxin (ETX), a potential agent of biological and toxic warfare, causes the death of many ruminants and threatens human health. It is crucial to understand the toxic mechanism of such a highly lethal and rapid course toxin.
Nan Yue, Jing Huang, Mingxin Dong, Jiaxin Li, Shan Gao, Jing Wang, Yingshuang Wang, Dongxue Li, Xi Luo, Tingting Liu, Songyang Han, Lina Dong, Ming Chen, Jinglin Wang, Na Xu, Lin Kang, Wenwen Xin   +16 more
doaj   +1 more source

Scrutinizing spliceosomes [PDF]

Nature Reviews Genetics, 2018
openaire   +2 more sources

RNA11 protein is associated with the yeast spliceosome and is localized in the periphery of the cell nucleus.

, 1988
Tien‐Hsien Chang, Megan Clark, Arthur J. Lustig, Michael E. Cusick, John Abelson   +4 more
openalex   +2 more sources