Results 11 to 20 of about 58,017 (329)

Structure of a pre-catalytic spliceosome

Nature, 2017
Intron removal requires assembly of the spliceosome on precursor mRNA (pre-mRNA) and extensive remodelling to form the spliceosome’s catalytic centre.
C. Plaschka, P. Lin, K. Nagai
semanticscholar   +2 more sources

A Novel N‐Terminal PRPF6 Variant in Autosomal Dominant Retinitis Pigmentosa

Clinical Case Reports
This report identifies the first N‐terminal PRPF6 variant (c.514C>T) as a cause of autosomal dominant Retinitis Pigmentosa. This novel variant is associated with progressive peripheral vision loss but notably preserved central visual acuity, suggesting a
Na Li, Yalong Dang
doaj   +2 more sources

Spliceosomal snRNA Epitranscriptomics [PDF]

Frontiers in Genetics, 2021
Small nuclear RNAs (snRNAs) are critical components of the spliceosome that catalyze the splicing of pre-mRNA. snRNAs are each complexed with many proteins to form RNA-protein complexes, termed as small nuclear ribonucleoproteins (snRNPs), in the cell nucleus. snRNPs participate in pre-mRNA splicing by recognizing the critical sequence elements present
Pedro Morais, Hironori Adachi, Yi-Tao Yu
openaire   +3 more sources

Spliceosomal immunophilins [PDF]

FEBS Letters, 2008
The spliceosome is a dynamic, macromolecular complex, which removes non‐protein‐coding introns from pre‐mRNA to form mature mRNA in a process known as splicing. This ribonucleoprotein assembly is comprised of five uridine‐rich small nuclear RNAs (snRNAs) as well as over 300 proteins.
Mesa, Annia, Somarelli, Jason A., Herrera, Rene J.   +2 more
openaire   +2 more sources

Spliceosome structure and function. [PDF]

Cold Spring Harbor Perspectives in Biology, 2011
Pre-mRNA splicing is catalyzed by the spliceosome, a multimegadalton ribonucleoprotein (RNP) complex comprised of five snRNPs and numerous proteins. Intricate RNA-RNA and RNP networks, which serve to align the reactive groups of the pre-mRNA for catalysis, are formed and repeatedly rearranged during spliceosome assembly and catalysis.
C. Will, R. Lührmann
semanticscholar   +4 more sources

Spliceosomal intronogenesis [PDF]

Proceedings of the National Academy of Sciences, 2016
Significance Eukaryotic transcripts contain spliceosomal introns that need to be removed by pre-mRNA splicing. Although several models have been proposed to identify the mechanism of intron gain over the evolution of eukaryotes, they remain models due to a lack of experimental validation.
Sujin, Lee, Scott W, Stevens
openaire   +2 more sources

A day in the life of the spliceosome

Nature reviews. Molecular cell biology, 2014
Gregory Matera, Zefeng Wang
semanticscholar   +2 more sources

Pre-mRNA splicing-associated diseases and therapies

RNA Biology, 2023
Precursor mRNA (pre-mRNA) splicing is an essential step in human gene expression and is carried out by a large macromolecular machine called the spliceosome.
Sierra L. Love, Joseph D. Emerson, Kazunori Koide, Aaron A. Hoskins   +3 more
doaj   +1 more source

U5 snRNP Core Proteins Are Key Components of the Defense Response against Viral Infection through Their Roles in Programmed Cell Death and Interferon Induction

Viruses, 2022
The spliceosome is a massive ribonucleoprotein structure composed of five small nuclear ribonucleoprotein (snRNP) complexes that catalyze the removal of introns from pre-mature RNA during constitutive and alternative splicing. EFTUD2, PRPF8, and SNRNP200
Simon Boudreault, Guy Lemay, Martin Bisaillon   +2 more
doaj   +1 more source

Structure of the activated human minor spliceosome

Science, 2021
Atomic structure of the minor spliceosome About 1% of the human genome contains the so-called U12-type introns, which are spliced by the minor spliceosome.
R. Bai, R. Wan, Lin Wang, Kui Xu, Q. Zhang, Jianlin Lei, Yigong Shi   +6 more
semanticscholar   +1 more source