Results 11 to 20 of about 53,406 (189)

Alternative splicing: transcriptional regulatory network in agroforestry

Frontiers in Plant Science, 2023
Alternative splicing (AS) in plants plays a key role in regulating the expression of numerous transcripts from a single gene in a regulatory pathway. Variable concentrations of growth regulatory hormones and external stimuli trigger alternative splicing ...
Syed Sarfaraz Hussain, Syed Sarfaraz Hussain, Manzar Abbas, Sammar Abbas, Mingke Wei, Ahmed H. El-Sappah, Ahmed H. El-Sappah, Yuhan Sun, Yun Li, Arthur J. Ragauskas, Arthur J. Ragauskas, Arthur J. Ragauskas, Quanzi Li   +12 more
doaj   +1 more source

Structure of the activated human minor spliceosome

Science, 2021
Atomic structure of the minor spliceosome About 1% of the human genome contains the so-called U12-type introns, which are spliced by the minor spliceosome.
R. Bai, R. Wan, Lin Wang, Kui Xu, Q. Zhang, Jianlin Lei, Yigong Shi   +6 more
semanticscholar   +1 more source

Engineering Crystal Packing in RNA-Protein Complexes II: A Historical Perspective from the Structural Studies of the Spliceosome

Crystals, 2021
Cryo-electron microscopy has greatly advanced our understanding of how the spliceosome cycles through different conformational states to conduct the chemical reactions that remove introns from pre-mRNA transcripts.
Adelaine Kwun-Wai Leung, Yasushi Kondo, Daniel A. Pomeranz Krummel, Jade Li, Stephen R. Price, Anne-Marie M. van Roon   +5 more
doaj   +1 more source

Structural basis of branch site recognition by the human spliceosome

Science, 2021
Description Intron recognition in the spotlight Excision of noncoding introns from pre–messenger RNAs is catalyzed by the spliceosome, a large RNA-protein complex that recognizes specific sequences at the exon-intron boundaries (splice sites).
J. Tholen, M. Rażew, F. Weis, W. P. Galej   +3 more
semanticscholar   +1 more source

Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription. [PDF]

, 2020
Deregulated expression of MYC induces a dependence on the NUAK1 kinase, but the molecular mechanisms underlying this dependence have not been fully clarified.
Ade, C.P., Baluapuri, A., Chang, Y.C., Cossa, G., Eilers, M., Girard, C., Kempa, S., Kumar, A., Kuster, B., Lührmann, R., Mastrobuoni, G., Mumberg, D., Prinz, F., Roeschert, I., Schülein-Völk, C., Silveira Vidal, R., Walz, S., Wolf, E., Wortmann, L.   +18 more
core   +1 more source

Aberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome. [PDF]

, 2015
Somatic mutations in the spliceosome gene ZRSR2-located on the X chromosome-are associated with myelodysplastic syndrome (MDS). ZRSR2 is involved in the recognition of 3'-splice site during the early stages of spliceosome assembly; however, its precise ...
Ganser, Arnold, Grossmann, Vera, Haferlach, Torsten, Kanojia, Deepika, Koeffler, H Phillip, Kohlmann, Alexander, Li, Jia, Madan, Vikas, Miyano, Satoru, Ogawa, Seishi, Okamoto, Ryoko, Sanada, Masashi, Sato-Otsubo, Aiko, Shiraishi, Yuichi, Sundaresan, Janani, Thol, Felicitas, Yang, Henry   +16 more
core   +5 more sources

USP15 regulates dynamic protein-protein interactions of the spliceosome through deubiquitination of PRP31. [PDF]

, 2017
Post-translational modifications contribute to the spliceosome dynamics by facilitating the physical rearrangements of the spliceosome. Here, we report USP15, a deubiquitinating enzyme, as a regulator of protein-protein interactions for the spliceosome ...
Das, Tanuza, Kim, Eunice EunKyeong, Kim, Eunji, Park, Jinyoung, Park, Joon Kyu, Rape, Michael, Song, Eun Joo   +6 more
core   +1 more source

In Vitro Studies of the Prp9·Prp11·Prp21 Complex Indicate a Pathway for U2 Small Nuclear Ribonucleoprotein Activation [PDF]

, 1996
Pre-mRNA splicing takes place on a large ribonucleoprotein particle, the spliceosome which contains the five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6. In Saccharomyces cerevisiae the mRNA splicing factors, Prp9, Prp11, and Prp21,
Abelson, John, O'Day, Christine L., Wiest, Debra K.   +2 more
core   +1 more source

The 35S U5 snRNP is generated from the activated spliceosome during In vitro splicing [PDF]

, 2015
Primary gene transcripts of eukaryotes contain introns, which are removed during processing by splicing machinery. Biochemical studies In vitro have identified a specific pathway in which introns are recognised and spliced out. This occurs by progressive
Barbara Bardoni, CL Will, CL Will, DE Agafonov, EM Makarov, EM Makarov, Evgeny M. Makarov, J Deckert, JD Dignam, K Hartmuth, MC Wahl, N Behzadnia, Olga V. Makarova, OV Makarova, OV Makarova, P Fabrizio, S Bessonov, S Bessonov, SE Behrens   +18 more
core   +8 more sources

Chromosomal instability by mutations in the novel minor spliceosome component CENATAC

EMBO Journal, 2021
Aneuploidy is the leading cause of miscarriage and congenital birth defects, and a hallmark of cancer. Despite this strong association with human disease, the genetic causes of aneuploidy remain largely unknown.
B. de Wolf, Ali Oghabian, M. Akinyi, S. Hanks, E. Tromer, Jolien J. E. van Hooff, Lisa van Voorthuijsen, Laura E van Rooijen, Jens Verbeeren, Esther C. H. Uijttewaal, Marijke P. A. Baltissen, Shawn E. Yost, P. Piloquet, M. Vermeulen, B. Snel, B. Isidor, N. Rahman, M. Frilander, G. Kops   +18 more
semanticscholar   +1 more source