Results 51 to 60 of about 53,406 (189)

A Role for Pre-mRNA-PROCESSING PROTEIN 40C in the Control of Growth, Development, and Stress Tolerance in Arabidopsis thaliana [PDF]

, 2019
Because of their sessile nature, plants have adopted varied strategies for growing and reproducing in an ever-changing environment. Control of mRNA levels and pre-mRNA alternative splicing are key regulatory layers that contribute to adjust and ...
Careno, Daniel Alejandro, de Leone, María José, García Hourquet, Mariano, Hernando, Carlos Esteban, Iserte, Javier Alonso, Mora Garcia, Santiago, Yanovsky, Marcelo Javier   +6 more
core   +1 more source

Discovery proteomics in aging human skeletal muscle finds change in spliceosome, immunity, proteostasis and mitochondria

eLife, 2019
A decline of skeletal muscle strength with aging is a primary cause of mobility loss and frailty in older persons, but the molecular mechanisms of such decline are not understood.
Ceereena Ubaida-Mohien, Alexey Lyashkov, Marta Gonzalez-Freire, Ravi Tharakan, Michelle Shardell, Ruin Moaddel, Richard D Semba, Chee W Chia, Myriam Gorospe, Ranjan Sen, Luigi Ferrucci   +10 more
doaj   +1 more source

A splicing-dependent transcriptional checkpoint associated with prespliceosome formation [PDF]

, 2014
There is good evidence for functional interactions between splicing and transcription in eukaryotes, but how and why these processes are coupled remain unknown.
Ahn, Aitken, Alexander, Alexander, Batsché, Bentley, Buratowski, Carrillo Oesterreich, Chapman, Chen, Cho, Cordin, Cramer, Damgaard, Das, David, de Almeida, Dönmez, Edgar, Egloff, Fong, Furger, Görnemann, Hirose, J. David Barrass, Jean D. Beggs, Ji, Kameoka, Keerthi T. Chathoth, Komarnitsky, Kornblihtt, Kornblihtt, Kosowski, Lacadie, Levine, Li, Lin, McCracken, McKay, Miller, Moore, Orphanides, Perriman, Perriman, Perriman, Perriman, Pleiss, Ruby, Schmidt, Schneider, Schroeder, Shao, Shaun Webb, Singh, Tardiff, Wahl, Wells, Witten, Xu, Xu, Yan, Zavanelli, Zhou   +62 more
core   +1 more source

Molecular basis for the activation of human spliceosome

Nature Communications
The spliceosome executes pre-mRNA splicing through four sequential stages: assembly, activation, catalysis, and disassembly. Activation of the spliceosome, namely remodeling of the pre-catalytic spliceosome (B complex) into the activated spliceosome ...
Xiechao Zhan, Yichen Lu, Yigong Shi
doaj   +1 more source

An intimate view of a spliceosome component

eLife, 2015
A high-resolution structure reveals how the ribonucleoprotein particle called U1 snRNP engages with 5′ splice sites.
Timothy W Nilsen
doaj   +1 more source

SF3B1 mutations in myelodysplastic syndromes: A potential therapeutic target for modulating the entire disease process

Frontiers in Oncology, 2023
Myelodysplastic syndromes (MDS) are clonal hematologic malignancies characterized by ineffective hematopoiesis and dysplasia of the myeloid cell lineage and are characterized by peripheral blood cytopenia and an increased risk of transformation to acute ...
Moqin Jiang, Moqin Jiang, Moqin Jiang, Meng Chen, Meng Chen, Qian Liu, Qian Liu, Zhiling Jin, Zhiling Jin, Zhiling Jin, Xiangdong Yang, Xiangdong Yang, Weifeng Zhang, Weifeng Zhang   +13 more
doaj   +1 more source

Aberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia

Nature Communications, 2018
Spliceosome mutations are frequently found in myelodysplasia. Splicing alterations induced by these mutations, their precise targets, and the effect at the transcript level have not been fully elucidated.
Y. Shiozawa, L. Malcovati, A. Gallì, A. Sato-Otsubo, K. Kataoka, Yusuke Sato, Yosaku Watatani, Hiromichi Suzuki, T. Yoshizato, Kenichi Yoshida, M. Sanada, H. Makishima, Y. Shiraishi, K. Chiba, E. Hellström-Lindberg, S. Miyano, S. Ogawa, M. Cazzola   +17 more
semanticscholar   +1 more source

Mud2 functions in transcription by recruiting the Prp19 and TREX complexes to transcribed genes [PDF]

, 2018
The different steps of gene expression are intimately linked to coordinate and regulate this complex process. During transcription, numerous RNA-binding proteins are already loaded onto the nascent mRNA and package the mRNA into a messenger ...
Georgieva, Sofia, Hüttelmaier, Stefan, Kopytova, Daria, Minocha, Rashmi, Misiak, Danny, Popova, Varvara, Sträßer, Katja   +6 more
core   +1 more source

A Quantitative Approach to Investigating the Hypothesis of Prokaryotic Intron Loss [PDF]

, 2011
Using a novel method, we show that ordered triplets of motifs usually associated with spliceosomal intron recognition are underrepresented in the protein coding sequence of complete Thermotogae, archaeal and bacterial genomes.
Robert M. Sinclair
core   +1 more source

Mutation of Arabidopsis SPLICEOSOMAL TIMEKEEPER LOCUS1 Causes Circadian Clock Defects [PDF]

, 2012
The circadian clock plays a crucial role in coordinating plant metabolic and physiological functions with predictable environmental variables, such as dusk and dawn, while also modulating responses to biotic and abiotic challenges.
Brown, John WS, Harmer, Stacey L, Jones, Matthew A, McNicol, Jim, Simpson, Craig G, Williams, Brian A   +5 more
core   +1 more source