Results 71 to 80 of about 48,897 (224)

Structure of spliceosomal ribonucleoproteins [PDF]

F1000 Biology Reports, 2010
Splicing of the precursors of eukaryotic mRNA and some non-coding RNAs is catalyzed by the 'spliceosome', which comprises five RNA-protein complexes (small nuclear ribonucleoproteins, or snRNPs) that assemble in an ordered manner onto precursor-mRNAs. Much progress has been made in determining the gross morphology of spliceosomal assembly intermediates.
Krummel, Daniel Aaron Pomeranz, Nagai, Kiyoshi, Oubridge, Chris   +2 more
openaire   +2 more sources

Genetic Control of Tissue Remodeling by a Non‐Coding SNP in ITGA8 Explains Carotenoid‐Based Color Polymorphism in Marine Mollusks

Advanced Science, EarlyView.
In this study, the orange‐muscle giant abalone (Haliotis gigantea) is used as a model to identify a non‐coding SNP that disrupts the interaction between ITGA8 pre‐mRNA and the splicing factor ILF2, leading to altered ITGA8 splicing. These splicing changes promote carotenoid accumulation in abalone muscle through the regulation of tissue remodeling ...
Xiaohui Wei, Wenzhu Peng, Zekun Huang, Bingye Yang, Yiyu Wu, Minzhen Han, Yi Wang, Bingling Peng, Guosheng Hu, Jiawei Hong, Guijia Liu, Linwei Nie, Yang Gan, Miaoqin Huang, Xuan Luo, Weiwei You, Wen Liu, Caihuan Ke   +17 more
wiley   +1 more source

Control of 3′ splice site selection by the yeast splicing factor Fyv6

eLife
Pre-mRNA splicing is catalyzed in two steps: 5ʹ splice site (SS) cleavage and exon ligation. A number of proteins transiently associate with spliceosomes to specifically impact these steps (first and second step factors).
Katherine A Senn, Karli A Lipinski, Natalie J Zeps, Amory F Griffin, Max E Wilkinson, Aaron A Hoskins   +5 more
doaj   +1 more source

SF3B1 mutations in myelodysplastic syndromes: A potential therapeutic target for modulating the entire disease process

Frontiers in Oncology, 2023
Myelodysplastic syndromes (MDS) are clonal hematologic malignancies characterized by ineffective hematopoiesis and dysplasia of the myeloid cell lineage and are characterized by peripheral blood cytopenia and an increased risk of transformation to acute ...
Moqin Jiang, Moqin Jiang, Moqin Jiang, Meng Chen, Meng Chen, Qian Liu, Qian Liu, Zhiling Jin, Zhiling Jin, Zhiling Jin, Xiangdong Yang, Xiangdong Yang, Weifeng Zhang, Weifeng Zhang   +13 more
doaj   +1 more source

A bioinformatic analysis identifies circadian expression of splicing factors and time-dependent alternative splicing events in the HD-MY-Z cell line [PDF]

, 2019
The circadian clock regulates key cellular processes and its dysregulation is associated to several pathologies including cancer. Although the transcriptional regulation of gene expression by the clock machinery is well described, the role of the clock ...
Abreu, Mónica, Astaburuaga, Rosario, Basti, Alireza, Genov, Nikolai, Relógio, Angela   +4 more
core   +1 more source

Spliceosome Database: a tool for tracking components of the spliceosome [PDF]

Nucleic Acids Research, 2012
The spliceosome is the extremely complex macromolecular machine responsible for pre-mRNA splicing. It assembles from five U-rich small nuclear RNAs (snRNAs) and over 200 proteins in a highly dynamic fashion. One important challenge to studying the spliceosome is simply keeping track of all these proteins, a situation further complicated by the variety ...
Cvitkovic, Ivan, Jurica, Melissa S
openaire   +4 more sources

Prenatal Evaluation of RNU4‐2 Variants in Fetuses With Central Nervous System Anomalies

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Fetal central nervous system (CNS) anomalies are among the most common congenital malformations, yet the overall prenatal diagnostic yield of current genetic testing remains below 40%. Variants in RNU4‐2, a non‐coding gene encoding the U4 small nuclear RNA (snRNA), have recently been linked to a novel highly recurrent dominant ...
Yiyao Chen, Li Gao, Xu Han, Yunyun Cao, Lanlan Zhang, Yi Wu, Xinrong Zhao, Wenjing Hu, Ruiyu Ma, Renyi Hua, Niu Li, Yanlin Wang, Jian Wang, Shuyuan Li   +13 more
wiley   +1 more source

USP15 Drives NSCLC Progression and Chemoresistance, Potentially via Regulation of the U2‐Type Spliceosomal Complex

Cancer Medicine
Objective Non‐small cell lung cancer (NSCLC) is an aggressive and lethal malignancy with the highest cancer‐related mortality rate. More than 50% of patients are diagnosed at advanced stages, often accompanied by chemoresistance and poor prognosis ...
Chien‐Chih Chiu, Sheng‐Kai Hsu, Wangta Liu, I‐Ling Lin, Wenhua Qiu, Ching‐Hung Hsieh, Chon‐Kit Chou   +6 more
doaj   +1 more source

Unleashing the potential of catalytic RNAs to combat mis-spliced transcripts

Frontiers in Bioengineering and Biotechnology, 2023
Human transcriptome can undergo RNA mis-splicing due to spliceopathies contributing to the increasing number of genetic diseases including muscular dystrophy (MD), Alzheimer disease (AD), Huntington disease (HD), myelodysplastic syndromes (MDS).
Bashayer A. Khalifah, Bashayer A. Khalifah, Shareefa A. Alghamdi, Ali H. Alhasan, Ali H. Alhasan   +4 more
doaj   +1 more source

Writing a wrong: Coupled RNA polymerase II transcription and RNA quality control [PDF]

, 2019
Processing and maturation of precursor RNA species is coupled to RNA polymerase II transcription. Co-transcriptional RNA processing helps to ensure efficient and proper capping, splicing, and 3' end processing of different RNA species to help ensure ...
Hughes, Katlyn D., Mosley, Amber L., Peck, Sarah A., Victorino, Jose F.   +3 more
core   +1 more source