Results 71 to 80 of about 53,406 (189)

Control of human papillomavirus gene expression by alternative splicing [PDF]

, 2017
Human papillomaviruses possess circular double stranded DNA genomes of around 8 kb in size from which multiple mRNAs are synthesized during an infectious life cycle.
Faizo, Arwa Ali A., Graham, Sheila
core   +1 more source

Identifying RNA splicing factors using IFT genes in Chlamydomonas reinhardtii [PDF]

, 2018
Intraflagellar transport moves proteins in and out of flagella/cilia and it is essential for the assembly of these organelles. Using whole-genome sequencing, we identified splice site mutations in two IFT genes,
Dutcher, Susan K., Iomini, Carlo, Lin, Huawen, Zhang, Zhengyan   +3 more
core   +2 more sources

Spliceosome Mutations Induce R Loop-Associated Sensitivity to ATR Inhibition in Myelodysplastic Syndromes.

Cancer Research, 2018
Heterozygous somatic mutations in spliceosome genes (U2AF1, SF3B1, ZRSR2, or SRSF2) occur in >50% of patients with myelodysplastic syndrome (MDS). These mutations occur early in disease development, suggesting that they contribute to MDS pathogenesis and
Hai Dang Nguyen, W. Leong, Weiling Li, Pavankumar N G Reddy, Jack D. Sullivan, M. Walter, L. Zou, T. Graubert   +7 more
semanticscholar   +1 more source

At the Intersection of Major and Minor Spliceosomes: Crosstalk Mechanisms and Their Impact on Gene Expression

Frontiers in Genetics, 2021
Many eukaryotic species contain two separate molecular machineries for removing non-coding intron sequences from pre-mRNA molecules. The majority of introns (more than 99.5% in humans) are recognized and excised by the major spliceosome, which utilizes ...
Maureen V. Akinyi, Mikko J. Frilander
doaj   +1 more source

αCP binding to a cytosine-rich subset of polypyrimidine tracts drives a novel pathway of cassette exon splicing in the mammalian transcriptome. [PDF]

, 2016
Alternative splicing (AS) is a robust generator of mammalian transcriptome complexity. Splice site specification is controlled by interactions of cis-acting determinants on a transcript with specific RNA binding proteins.
Bahrami-Samani, Emad, Duncan-Lewis, Christopher, Ji, Xinjun, Liebhaber, Stephen A, Lin, Lan, Park, Juw Won, Pherribo, Gordon, Xing, Yi   +7 more
core   +1 more source

Structure of a pre-catalytic spliceosome

Nature, 2017
Intron removal requires assembly of the spliceosome on precursor mRNA (pre-mRNA) and extensive remodelling to form the spliceosome’s catalytic centre.
C. Plaschka, P. Lin, K. Nagai
semanticscholar   +1 more source

OSI-027 as a Potential Drug Candidate Targeting Upregulated Hub Protein TAF1 in Potential Mechanism of Sinonasal Squamous Cell Carcinoma: Insights from Proteomics and Molecular Docking

Biology
Sinonasal squamous cell carcinoma (SNSCC) is a rare tumor with high mortality and recurrence rates. However, SNSCC carcinogenesis mechanisms and potential therapeutic drugs have not been fully elucidated.
Watcharapong Panthong, Chamsai Pientong, Thawaree Nukpook, Chukkris Heawchaiyaphum, Sirinart Aromseree, Tipaya Ekalaksananan   +5 more
doaj   +1 more source

Cooperative Analysis of Structural Dynamics in RNA-Protein Complexes by Single-Molecule Förster Resonance Energy Transfer Spectroscopy

Molecules, 2020
RNA-protein complexes (RNPs) are essential components in a variety of cellular processes, and oftentimes exhibit complex structures and show mechanisms that are highly dynamic in conformation and structure.
Nathalie Meiser, Christin Fuks, Martin Hengesbach   +2 more
doaj   +1 more source

Impact of spliceosome mutations on RNA splicing in myelodysplasia: dysregulated genes/pathways and clinical associations.

Blood, 2018
SF3B1, SRSF2, and U2AF1 are the most frequently mutated splicing factor genes in the myelodysplastic syndromes (MDS). We have performed a comprehensive and systematic analysis to determine the effect of these commonly mutated splicing factors on pre-mRNA
A. Pellagatti, R. Armstrong, V. Steeples, E. Sharma, E. Repapi, Shalini Singh, Andrea Sanchi, A. Radujkovic, P. Horn, H. Dolatshad, Swagata Roy, J. Broxholme, H. Lockstone, S. Taylor, A. Giagounidis, P. Vyas, A. Schuh, A. Hamblin, E. Papaemmanuil, S. Killick, L. Malcovati, M. L. Hennrich, A. Gavin, A. Ho, T. Luft, E. Hellström-Lindberg, M. Cazzola, Christopher W. J. Smith, Stephen P Smith, J. Boultwood   +29 more
semanticscholar   +1 more source

Decrypting the information exchange pathways across the spliceosome machinery.

Journal of the American Chemical Society, 2020
Intron splicing of a nascent messenger RNA transcript by spliceosome (SPL) is a hallmark of gene regulation in eukaryotes. SPL is a majestic molecular machine composed of an entangled network of proteins and RNAs that meticulously promotes intron ...
Andrea Saltalamacchia, L. Casalino, J. Borišek, Victor S. Batista, I. Rivalta, A. Magistrato   +5 more
semanticscholar   +1 more source