Results 91 to 100 of about 34,718 (253)

USB1 deficiency disrupts neutrophil maturation via RNA dysregulation independent of global pre‐mRNA splicing

Animal Models and Experimental Medicine, EarlyView.
This graphical abstract illustrates the essential role of USB1 in neutrophil maturation. In normal myeloid cells, USB1 acts as an RNA exonuclease, trimming RNA tails to maintain proper RNA network function, which supports the differentiation of myeloid progenitor cells into mature neutrophils.
Hang Li, Guiying Shi, Jiaming Tang, Yiying Huang, Jie Wang, Xuepei Lei, Lin Bai   +6 more
wiley   +1 more source

The metabolic reprogramming and vulnerability of SF3B1 mutations

Molecular & Cellular Oncology, 2020
Mutations in the splicing factor 3b subunit 1 (SF3B1) gene create a neomorphic protein that disrupts RNA splicing, but the downstream consequences of this missplicing are unclear.
W. Brian Dalton
doaj   +1 more source

The significant other: splicing by the minor spliceosome

, 2013
Peer ...
Elina H. Niemelä, Bhupendra Verma, Mikko J. Frilander, Janne J. Turunen, Frilander, Mikko J., Niemela, Elina H., Verma, Bhupendra, Turunen, Janne J.   +7 more
core   +1 more source

The spliceosome as a new therapeutic vulnerability in aggressive prostate cancer

Molecular & Cellular Oncology, 2020
Alternative splicing (AS) analysis across the entire spectrum of human prostate cancer evolution reveals the unexpected findings that intron retention is a hallmark of stemness and tumor aggressiveness, and androgen receptor controls a splicing program ...
Cheng Zou, Dingxiao Zhang
doaj   +1 more source

Splicing Players Are Differently Expressed in Sporadic Amyotrophic Lateral Sclerosis Molecular Clusters and Brain Regions

Cells, 2020
Splicing is a tightly orchestrated process by which the brain produces protein diversity over time and space. While this process specializes and diversifies neurons, its deregulation may be responsible for their selective degeneration.
Valentina La Cognata, Giulia Gentile, Eleonora Aronica, Sebastiano Cavallaro   +3 more
doaj   +1 more source

Differential Proteomic Analysis to Reveal the Mechanism of Heat Damage in Soybean Using a Data‐Independent Acquisition (DIA) Strategy

Food Safety and Health, EarlyView.
Heat‐stressed soybeans adapt to elevated temperatures through coordinate regulation of destructive and protective protein expression ‐ suppressing detrimental proteins while enhancing beneficial ones. ABSTRACT Soybean represents the largest imported agricultural product in China. Imported soybeans are typically transported via maritime shipping. During
Pengdi Ding, Qinfei Xie, Jiajing Duan, Yinghao Feng, Fengzhong Wang, Yufeng Sun   +5 more
wiley   +1 more source

Multi‐Cohort Analysis Reveals Genetic Predispositions to Clonal Hematopoiesis as Mutation‐Specific Risk Factors for Stroke

Advanced Genetics, Volume 6, Issue 1, March 2025.
This study comprehensively evaluated the differential effect of clonal hematopoiesis (CH) mutations on the risk of various stroke subtypes and functional recovery. It shows that TET2 is associated with small vessel stroke possibly via a pro‐inflammatory pathway. Abstract Recent observational studies have found an association between Clonal Hematopoesis
Shuyang Lin, Yang E. Li, Yan Wang
wiley   +1 more source

Structure of a human catalytic step I spliceosome

, 2018
Structure of the human spliceosome Catalyzed by the spliceosome, precursor mRNA splicing proceeds in two steps: branching and exon ligation. Transition from the C (catalytic post-branching spliceosome) to the C* (catalytic pre-exon
Jianlin Lei, Yigong Shi, Xiechao Zhan, Xiaofeng Zhang, Chuangye Yan   +4 more
core   +1 more source

Substrate Characterization of Mycobacterial Kinase PknG Revealing PknG‐KARS‐MAPK Phosphorylation Signaling Axis in Host

iMetaMed, EarlyView.
This study employed multi‐omics approaches to investigate the regulatory mechanism of Mycobacterium PknG on host cell processes. We found that host lysine‐tRNA ligase (KARS) is a potential substrate of PknG; and PknG can regulate the immune response by catalyzing the phosphorylation of KARS at T592 and T595 sites, affecting the phosphorylation level in
Nana Tian, Shuyu Xie, Yanqing Tang, Junjie Liang, Wenhan Zhu, Tianqi Liu, Yewen Sun, Yang Yang, Luoxi Zhang, Danfeng Wang, Chuyao Lin, Jinyu Jia, Minjia Tan, Jun‐Yu Xu   +13 more
wiley   +1 more source

A close-up look at the spliceosome, at last

, 2017
Major developments in cryo-electron microscopy in the past three or four years have led to the solution of a number of spliceosome structures at high resolution, e.g., the fully assembled but not yet active spliceosome (Bact), the spliceosome just after ...
John Abelson
core   +1 more source