Results 101 to 110 of about 37,352 (250)
Advanced Genetics, Volume 6, Issue 1, March 2025.This study comprehensively evaluated the differential effect of clonal hematopoiesis (CH) mutations on the risk of various stroke subtypes and functional recovery. It shows that TET2 is associated with small vessel stroke possibly via a pro‐inflammatory pathway. Abstract Recent observational studies have found an association between Clonal Hematopoesis
Shuyang Lin, Yang E. Li, Yan Wang
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Structure of a human catalytic step I spliceosome
, 2018 Structure of the human spliceosome Catalyzed by the spliceosome, precursor mRNA splicing proceeds in two steps: branching and exon ligation. Transition from the C (catalytic post-branching spliceosome) to the C* (catalytic pre-exon
Jianlin Lei +4 more
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Spliceosome mutations in Uveal Melanoma Supplementary
, 2020 Supplementary data of "Spliceosome mutations in Uveal ...
J.Q.N. Nguyen
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PLoS ONE, 2018 The spliceosome is a large ribonucleoprotein complex that catalyzes the removal of introns from RNA polymerase II-transcribed RNAs. Spliceosome assembly occurs in a stepwise manner through specific intermediates referred to as pre-spliceosome complexes E,
Erin J Vanzyl +4 more
doaj +1 more source
Potential Neuroendocrine Disruption by Benzodiazepines and Its Impact on Male Fertility
Journal of Applied Toxicology, EarlyView.ABSTRACT Neuroactive substances have emerged as potent endocrine disruptors affecting male reproductive health through central and peripheral mechanisms. Among these, benzodiazepines, which are widely used for the management of anxiety, insomnia, epilepsy, and neuromuscular disorders, are known as GABA A (gamma‐aminobutyric acid type A) receptor ...
Ana Clara Melo Andrade de Rodrigues +3 more
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Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research
Mass Spectrometry Reviews, EarlyView.Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik +3 more
wiley +1 more source
Dissecting spliceosome function with small-molecule inhibitors [PDF]
, 2015 In eukaryotes, a crucial step in gene expression is pre-mRNA splicing by the spliceosome. The spliceosome is a macromolecular machine that removes intervening intron sequences from over 95% of human transcripts to create a functional template for protein
Effenberger, Kerstin
core
A close-up look at the spliceosome, at last
, 2017 Major developments in cryo-electron microscopy in the past three or four years have led to the solution of a number of spliceosome structures at high resolution, e.g., the fully assembled but not yet active spliceosome (Bact), the spliceosome just after ...
John Abelson
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Tagging a Spliceosome Protein and Inhibiting Splicing in Cells [PDF]
, 2022 The spliceosome is an important molecular complex that converts pre-mRNA to mRNA. It removes non-coding regions of RNA known as introns and connects the exons through a two-step chemical reaction. The spliceosome is made up of five snRNPs and dozens of
Bredeson, Sean
core
Pest Management Science, EarlyView.Transcriptome sequencing of Ceutorhynchus obstrictus revealed RNA interference (RNAi) targets; double‐stranded RNA microinjection reduced transcript levels and increased mortality, with αCOP and Rop showing strongest lethal effects, indicating promising RNAi‐based pest control candidates.
Apurva Vikas Sabnis +8 more
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