Results 1 to 10 of about 7,418 (222)

Spliceosomal snRNA Epitranscriptomics [PDF]

Frontiers in Genetics, 2021
Small nuclear RNAs (snRNAs) are critical components of the spliceosome that catalyze the splicing of pre-mRNA. snRNAs are each complexed with many proteins to form RNA-protein complexes, termed as small nuclear ribonucleoproteins (snRNPs), in the cell ...
Pedro Morais, Hironori Adachi, Yi-Tao Yu
doaj   +3 more sources

Structure of a step II catalytically activated spliceosome from Chlamydomonas reinhardtii [PDF]

The EMBO Journal
Pre-mRNA splicing, a fundamental step in eukaryotic gene expression, is executed by the spliceosomes. While there is extensive knowledge of the composition and structure of spliceosomes in yeasts and humans, the structural diversity of spliceosomes in ...
Yichen Lu, Ke Liang, Xiechao Zhan
doaj   +2 more sources

Crosstalk between chromatin state and ATM signalling in DNA damage-induced transcription stress [PDF]

The EMBO Journal
The DNA Damage Response (DDR) is a highly regulated process that safeguards genomic integrity against DNA lesions. Increasing evidence supports a reciprocal relationship between damaged chromatin architecture and the signalling pathways that coordinate ...
Irene Salas-Armenteros, Maarten Klunder, Wim Vermeulen, Maria Tresini   +3 more
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PRPF8-mediated dysregulation of hBrr2 helicase disrupts human spliceosome kinetics and 5´-splice-site selection causing tissue-specific defects [PDF]

Nature Communications
The carboxy-terminus of the spliceosomal protein PRPF8, which regulates the RNA helicase Brr2, is a hotspot for mutations causing retinitis pigmentosa-type 13, with unclear role in human splicing and tissue-specificity mechanism.
Robert Atkinson, Maria Georgiou, Chunbo Yang, Katarzyna Szymanska, Albert Lahat, Elton J. R. Vasconcelos, Yanlong Ji, Marina Moya Molina, Joseph Collin, Rachel Queen, Birthe Dorgau, Avril Watson, Marzena Kurzawa-Akanbi, Ross Laws, Abhijit Saxena, Chia Shyan Beh, Chileleko Siachisumo, Franziska Goertler, Magdalena Karwatka, Tracey Davey, Chris F. Inglehearn, Martin McKibbin, Reinhard Lührmann, David H. Steel, David J. Elliott, Lyle Armstrong, Henning Urlaub, Robin R. Ali, Sushma-Nagaraja Grellscheid, Colin A. Johnson, Sina Mozaffari-Jovin, Majlinda Lako   +31 more
doaj   +2 more sources

Dynamics and evolutionary conservation of B complex protein recruitment during spliceosome activation. [PDF]

Nucleic Acids Res
Fu X, Hoskins AA.
europepmc   +3 more sources

Spliceosome [PDF]

Science-Business eXchange, 2008

  +6 more sources

SnapShot: Spliceosome Dynamics II

Cell, 2015
Spliceosomes are multi-megadalton RNA-protein molecular machines that carry out pre-mRNA splicing, that is, the removal of non-coding intervening sequences (introns) from eukaryotic pre-mRNAs and the ligation of neighboring coding regions (exons) to produce mature mRNA for protein biosynthesis on the ribosome.
M.C. Wahl, Reinhard Lührmann
openalex   +8 more sources

Identification of the TSSK4 Alternative Spliceosomes and Analysis of the Function of the TSSK4 Protein in Yak (Bos grunniens)

Animals, 2022
In mammals, the testis-specific serine/threonine kinase (TSSK) is essential for spermatogenesis and male fertility. TSSK4 belongs to the family of the testis-specific serine/threonine-protein kinase (TSSK), with a crucial role in spermatogenesis.
Xingdong Wang, Jie Pei, Lin Xiong, Shaoke Guo, Mengli Cao, Yandong Kang, Pengjia Bao, Xiaoyun Wu, Min Chu, Chunnian Liang, Ping Yan, Xian Guo   +11 more
doaj   +1 more source

Spliceosomal immunophilins [PDF]

FEBS Letters, 2008
The spliceosome is a dynamic, macromolecular complex, which removes non‐protein‐coding introns from pre‐mRNA to form mature mRNA in a process known as splicing. This ribonucleoprotein assembly is comprised of five uridine‐rich small nuclear RNAs (snRNAs) as well as over 300 proteins.
Mesa, Annia, Somarelli, Jason A., Herrera, Rene J.   +2 more
openaire   +2 more sources

Spliceosomal intronogenesis [PDF]

Proceedings of the National Academy of Sciences, 2016
Significance Eukaryotic transcripts contain spliceosomal introns that need to be removed by pre-mRNA splicing. Although several models have been proposed to identify the mechanism of intron gain over the evolution of eukaryotes, they remain models due to a lack of experimental validation.
Sujin, Lee, Scott W, Stevens
openaire   +2 more sources