Results 101 to 110 of about 7,418 (222)

Generation of functional noncanonical donor splice sites by +2T variants in breast cancer susceptibility genes: impact on clinical interpretation

The Journal of Pathology, Volume 268, Issue 2, Page 150-163, February 2026.
Abstract Splicing dysregulation is a relevant mechanism of pathogenicity for variants in disease susceptibility genes. Variants affecting the critical intronic +1 and +2 GT nucleotides of the 5’ splice sites (5'ss) are generally strong indicators of pathogenicity.
Inés Llinares‐Burguet, Lara Sanoguera‐Miralles, Elena Bueno‐Martínez, Alicia García‐Álvarez, Alberto Valenzuela‐Palomo, Pedro Pérez‐Segura, Miguel de la Hoya, Eladio A Velasco‐Sampedro   +7 more
wiley   +1 more source

In Vivo Chemical Reprogramming Is Associated With a Toxic Accumulation of Lipid Droplets Hindering Rejuvenation

Aging Cell, Volume 25, Issue 2, February 2026.
Partial chemical reprogramming significantly increases mitochondrial interaction networks, affects mitochondrial morphology, speeds up mitochondrial movement dynamics, increases mitochondrial transmembrane potential, and induces TCA cycle stress. These changes in mitochondrial function contribute to lipid droplet accumulation, acute kidney injury, and ...
Wayne Mitchell, Cecília G. de Magalhães, Alexander Tyshkovskiy, Yushi Uchida, Ludger J. E. Goeminne, Takaharu Ichimura, Emery L. Ng, Alibek Moldakozhayev, Joseph V. Bonventre, Vadim N. Gladyshev   +9 more
wiley   +1 more source

Regulation of R‐Loop Dynamics by Proteins and Long Noncoding RNAs: An Emerging Paradigm for Cancer Treatment

Cancer Science, Volume 117, Issue 2, Page 297-307, February 2026.
R‐loops are three‐stranded nucleic acid structures whose dysregulation leads to genomic instability and cancer progression. This review summarizes the protein and lncRNA machineries that regulate R‐loop dynamics and discusses the therapeutic potential of targeting these pathways in cancer.
Miho M. Suzuki, Keiko Shinjo, Tatsunori Nishimura, Yutaka Kondo   +3 more
wiley   +1 more source

Partial purification of the yeast U2 snRNP reveals a novel yeast pre-mRNA splicing factor required for pre-spliceosome assembly [PDF]

, 1999
Friederike Caspary
openalex   +1 more source

Mining Potential Therapeutic Targets for T Cell Exhaustion in Osteoarthritis by Integrating Mendelian Randomization and Single‐Cell Sequencing

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
This study conducted an integrated analysis using multi‐source data, with specific data sources including the GEO database (encompassing datasets GSE55235, GSE55457, and GSE152805), literature‐mined gene sets, and the IEU OpenGWAS database (dataset ebi‐a‐GCST005814).
Jiahong Li, Yi Ye, Yan Zhang, Wei Fang, Fei Lan, Qian Yang, Lun Wan, Jiang Hu, Chengwei Xiao, Kun Zhang   +9 more
wiley   +1 more source

Cryo-EM analyses of dimerized spliceosomes provide new insights into the functions of B complex proteins

The EMBO Journal
The B complex is a key intermediate stage of spliceosome assembly. To improve the structural resolution of monomeric, human spliceosomal B (hB) complexes and thereby generate a more comprehensive hB molecular model, we determined the cryo-EM structure of
Zhenwei Zhang, Vinay Kumar, Olexandr Dybkov, Cindy L Will, Henning Urlaub, Holger Stark, Reinhard Lührmann   +6 more
doaj   +1 more source

Spliceosomal Factor SmF Modulates Temperature‐Mediated Flower and Leaf Size Plasticity in Arabidopsis thaliana

Plant, Cell &Environment, EarlyView.
Gregory M. Andreou‐Huotari, Mikael Brosché, Jan Hoffmann, Zoran Nikoloski, Roosa A. E. Laitinen   +4 more
wiley   +1 more source

Gezielte Modulation des spliceosomalen Proteins USP39 durch allosterische Liganden und PROTAC‐induzierte Degradation

Angewandte Chemie, Volume 138, Issue 5, 28 January 2026.
Proteolysis‐targeting Chimeras (PROTACs) ermöglichen die gezielte Degradation bislang als „undruggable“ geltende Proteine über das zelluläre Ubiquitin–Proteasom‐System. In dieser Studie identifizieren Schäfer et al. thiazolbasierte niedermolekulare Liganden, die allosterisch an die Zinkfinger‐Domäne der Ubiquitin‐spezifischen Protease 39 (USP39) binden
Daniel Schäfer, Cristian Prieto‐Garcia, Jianhui Wang, Marcel Heinz, Vigor Matkovic, Pavel Kielkowski, Sebastian Hasselbeck, Varun Jayeshkumar Shah, Stefan Knapp, Gerhard Hummer, Ivan Dikic, Xinlai Cheng   +11 more
wiley   +1 more source

Targeting the Spliceosomal Protein USP39 Through Allosteric Ligands and PROTAC‐Induced Degradation

Angewandte Chemie International Edition, Volume 65, Issue 5, 28 January 2026.
Proteolysis‐targeting chimeras (PROTACs) enable degradation of proteins previously considered undruggable by harnessing the cellular ubiquitin–proteasome system. In this study, Schäfer et al. identify thiazole‐based small molecules that allosterically bind the zinc finger domain of ubiquitin‐specific protease 39 (USP39), a non‐enzymatic scaffold ...
Daniel Schäfer, Cristian Prieto‐Garcia, Jianhui Wang, Marcel Heinz, Vigor Matkovic, Pavel Kielkowski, Sebastian Hasselbeck, Varun Jayeshkumar Shah, Stefan Knapp, Gerhard Hummer, Ivan Dikic, Xinlai Cheng   +11 more
wiley   +1 more source

Versatile and Selective Biomolecule Pulldown with Combinatorial DNA‐Crosslinked Polymers

Angewandte Chemie International Edition, Volume 65, Issue 5, 28 January 2026.
We present a programmable smart polymer system for universal, sequence‐selective bioseparation under native conditions. Polymer phase separation is achieved through combinatorial DNA crosslinking, enabling the capture of DNA, RNA, or proteins in a homogeneous solution with high pulldown efficiency and near‐zero background binding.
Sarah K. Speed, Krishna Gupta, Yu‐Hsuan Peng, Elisha Krieg   +3 more
wiley   +1 more source