Results 11 to 20 of about 10,182 (283)

Surprisingly high number of Twintrons in vertebrates [PDF]

Biology Direct, 2013
Twintrons represent a special intronic arrangement in which introns of two different types occupy the same gene position. Consequently, alternative splicing of these introns requires two different spliceosomes competing for the same RNA molecule. So far,
Janice, J. (Jessin), Jąkalski, M. (Marcin), Makałowski, W. (Wojciech)   +2 more
core   +4 more sources

Identification of the TSSK4 Alternative Spliceosomes and Analysis of the Function of the TSSK4 Protein in Yak (Bos grunniens)

Animals, 2022
In mammals, the testis-specific serine/threonine kinase (TSSK) is essential for spermatogenesis and male fertility. TSSK4 belongs to the family of the testis-specific serine/threonine-protein kinase (TSSK), with a crucial role in spermatogenesis.
Xingdong Wang, Jie Pei, Lin Xiong, Shaoke Guo, Mengli Cao, Yandong Kang, Pengjia Bao, Xiaoyun Wu, Min Chu, Chunnian Liang, Ping Yan, Xian Guo   +11 more
doaj   +1 more source

PRPF8-mediated dysregulation of hBrr2 helicase disrupts human spliceosome kinetics and 5´-splice-site selection causing tissue-specific defects. [PDF]

Nat Commun
The carboxy-terminus of the spliceosomal protein PRPF8, which regulates the RNA helicase Brr2, is a hotspot for mutations causing retinitis pigmentosa-type 13, with unclear role in human splicing and tissue-specificity mechanism.
Atkinson R, Georgiou M, Yang C, Szymanska K, Lahat A, Vasconcelos EJR, Ji Y, Moya Molina M, Collin J, Queen R, Dorgau B, Watson A, Kurzawa-Akanbi M, Laws R, Saxena A, Shyan Beh C, Siachisumo C, Goertler F, Karwatka M, Davey T, Inglehearn CF, McKibbin M, Lührmann R, Steel DH, Elliott DJ, Armstrong L, Urlaub H, Ali RR, Grellscheid SN, Johnson CA, Mozaffari-Jovin S, Lako M.   +31 more
europepmc   +2 more sources

At the Intersection of Major and Minor Spliceosomes: Crosstalk Mechanisms and Their Impact on Gene Expression

Frontiers in Genetics, 2021
Many eukaryotic species contain two separate molecular machineries for removing non-coding intron sequences from pre-mRNA molecules. The majority of introns (more than 99.5% in humans) are recognized and excised by the major spliceosome, which utilizes ...
Maureen V. Akinyi, Mikko J. Frilander
doaj   +1 more source

Multi‐omics analyses reveal the interaction between colonic microbiota and host in Min and Yorkshire pigs

Animal Research and One Health, EarlyView., 2023
In the present study, we created the weight gain models with Min and Yorkshire pigs and conducted the metagenomics and metabolomics of colon contents and transcriptomics of colon tissue. Further, we revealed the characteristics and functions of the colonic microbiota in Min and Yorkshire pigs and analyzed their interactions with the host. Overall, this
Xiaoyu Huang, Huihui Li, Feng Cheng, Ligang Wang, Guoqing Cao, Lixian Wang, Lijun Shi   +6 more
wiley   +1 more source

Dynamic Supraspliceosomes Are Assembled on Different Transcripts Regardless of Their Intron Number and Splicing State

Frontiers in Genetics, 2020
Splicing and alternative splicing of pre-mRNA are key sources in the formation of diversity in the human proteome. These processes have a central role in the regulation of the gene expression pathway.
Naama Sebbag-Sznajder, Yehuda Brody, Hodaya Hochberg-Laufer, Yaron Shav-Tal, Joseph Sperling, Ruth Sperling   +5 more
doaj   +1 more source

Genome-Wide Identification, Expression Profile, and Alternative Splicing Analysis of CAMTA Family Genes in Cucumber (Cucumis sativus L.)

Agronomy, 2021
The calmodulin-binding transcription activator (CAMTA), as one of the most distinctive families of transcription factors, plays an important role in plant growth and development and in the stress response.
Rong Gao, Yanyan Luo, Fahong Yun, Xuetong Wu, Peng Wang, Weibiao Liao   +5 more
doaj   +1 more source

The minor spliceosomal protein U11/U12-31K is an RNA chaperone crucial for U12 intron splicing and the development of dicot and monocot plants. [PDF]

PLoS ONE, 2012
U12 intron-specific spliceosomes contain U11 and U12 small nuclear ribonucleoproteins and mediate the removal of U12 introns from precursor-mRNAs. Among the several proteins unique to the U12-type spliceosomes, an Arabidopsis thaliana AtU11/U12-31K ...
Kyung Jin Kwak, Hyun Ju Jung, Kwang Ho Lee, Young Soon Kim, Won Yong Kim, Sung Ju Ahn, Hunseung Kang   +6 more
doaj   +1 more source

Roles of alternative splicing in infectious diseases: from hosts, pathogens to their interactions

Chinese Medical Journal, 2023
. Alternative splicing (AS) is an evolutionarily conserved mechanism that removes introns and ligates exons to generate mature messenger RNAs (mRNAs), extremely improving the richness of transcriptome and proteome. Both mammal hosts and pathogens require
Mengyuan Lyu, Hongli Lai, Yili Wang, Yanbing Zhou, Yi Chen, Dongsheng Wu, Jie Chen, Binwu Ying, Peifang Wei   +8 more
doaj   +1 more source

Challenging the spliceosome machine [PDF]

Genome Biology, 2006
Abstract Background Using cDNA copies of transcripts and corresponding genomic sequences from the Berkeley Drosophila Genome Project, a set of 24,753 donor and acceptor splice sites were computed with a scanning algorithm that tested for single nucleotide insertion, deletion and substitution ...
Michael D. Rice, Matthew L. Eaton, Michael P. Weir   +2 more
openaire   +3 more sources