Results 11 to 20 of about 17,120 (319)
Human spliceosomal snRNA sequence variants generate variant spliceosomes
RNA, 2021 Human pre-mRNA splicing is primarily catalyzed by the major spliceosome, comprising five small nuclear ribonucleoprotein complexes, U1, U2, U4, U5, and U6 snRNPs, each of which contains the corresponding U-rich snRNA.
Justin W. Mabin +3 more
semanticscholar +3 more sources
Spliceosomal snRNA Epitranscriptomics [PDF]
Frontiers in Genetics, 2021 Small nuclear RNAs (snRNAs) are critical components of the spliceosome that catalyze the splicing of pre-mRNA. snRNAs are each complexed with many proteins to form RNA-protein complexes, termed as small nuclear ribonucleoproteins (snRNPs), in the cell ...
Pedro Morais, Hironori Adachi, Yi-Tao Yu
doaj +3 more sources
The human Prp8 protein is a component of both U2- and U12-dependent spliceosomes. [PDF]
RNA: A publication of the RNA Society, 1999 This study reports the cloning, sequencing, and development of antisera against the human U5 snRNP 220-kDa protein or hPrp8p. Prp8p is the most highly conserved large nuclear protein known to date, but it is not related to any other protein.
H. R. Luo, G. Moreau, N. Levin, M. Moore
semanticscholar +2 more sources
Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. [PDF]
RNA: A publication of the RNA Society, 2002 We describe characterization of spliceosomes affinity purified under native conditions. These spliceosomes consist largely of C complex containing splicing intermediates.
M. Jurica +4 more
semanticscholar +2 more sources
Control of 3′ splice site selection by the yeast splicing factor Fyv6 [PDF]
eLifePre-mRNA splicing is catalyzed in two steps: 5ʹ splice site (SS) cleavage and exon ligation. A number of proteins transiently associate with spliceosomes to specifically impact these steps (first and second step factors).
Katherine A Senn +5 more
doaj +2 more sources
Nucleic Acids Research, 2021 Vertebrate genomes contain major (>99.5%) and minor (
Anouk M Olthof +12 more
semanticscholar +1 more source
Animals, 2022 In mammals, the testis-specific serine/threonine kinase (TSSK) is essential for spermatogenesis and male fertility. TSSK4 belongs to the family of the testis-specific serine/threonine-protein kinase (TSSK), with a crucial role in spermatogenesis.
Xingdong Wang +11 more
doaj +1 more source
A model for DHX15 mediated disassembly of A-complex spliceosomes
bioRxiv, 2021 A critical step of pre-mRNA splicing is the recruitment of U2 snRNP to the branch point sequence of an intron. U2 snRNP conformation changes extensively during branch helix formation and several RNA-dependent-ATPases are implicated in the process ...
Hannah M. Maul-Newby +6 more
semanticscholar +1 more source