Results 201 to 210 of about 7,418 (222)
Some of the next articles are maybe not open access.
Architecture of the Spliceosome
Biochemistry, 2012Precursor-mRNA splicing is catalyzed by an extraordinarily large and highly dynamic macromolecular assemblage termed the spliceosome. Detailed biochemical and structural study of the spliceosome presents a formidable challenge, but there has recently been significant progress made on this front highlighted by the crystal structure of a 10-subunit human
Clarisse, van der Feltz +3 more
openaire +2 more sources
Science, 1996
In this issue of Science , Tarn and Steitz ( p. 1824 ) report the identification of two new RNAs that reside in the special spliceosome that acts on the rare AT-AC class of introns. In his Perspective, Nilsen describes why the now complete description of the RNA components of this spliceosome
openaire +2 more sources
In this issue of Science , Tarn and Steitz ( p. 1824 ) report the identification of two new RNAs that reside in the special spliceosome that acts on the rare AT-AC class of introns. In his Perspective, Nilsen describes why the now complete description of the RNA components of this spliceosome
openaire +2 more sources
Science, 1991
In cell extracts, the snRNAs exist associated with proteins as small nuclear ribonucleoproteins (snRNPs, pronounced «snurps»). In an in vitro splicing reaction, the snRNPs, other essential protein factors, and the pre-mRNA form a macromolecular complex known as a spliceosome.
openaire +2 more sources
In cell extracts, the snRNAs exist associated with proteins as small nuclear ribonucleoproteins (snRNPs, pronounced «snurps»). In an in vitro splicing reaction, the snRNPs, other essential protein factors, and the pre-mRNA form a macromolecular complex known as a spliceosome.
openaire +2 more sources
Mechanisms of Spliceosomal Assembly
2014Pre-mRNA splicing is a key step for generating mature protein-coding mRNA. An RNA-protein complex known as the spliceosome carries out the chemistry of pre-mRNA splicing. However, several pre-spliceosomal intermediates are assembled on the pre-mRNA before the formation of the catalytically activated spliceosome.
Ni-Ting, Chiou, Kristen W, Lynch
openaire +2 more sources
1997
Abstract Pre-mRNA splicing takes place within a large, highly dynamic complex designated the spliceosome. Spliceosomes are 50-60S, have a calculated molecular weight on the order of 3-5 × 106 kDa, and are estimated to be 40-60 nm in diameter (see 1, 2 for reviews). Among the best characterized of the spliceosomal components are the small
Robin Reed, Leon Palandjian
openaire +1 more source
Abstract Pre-mRNA splicing takes place within a large, highly dynamic complex designated the spliceosome. Spliceosomes are 50-60S, have a calculated molecular weight on the order of 3-5 × 106 kDa, and are estimated to be 40-60 nm in diameter (see 1, 2 for reviews). Among the best characterized of the spliceosomal components are the small
Robin Reed, Leon Palandjian
openaire +1 more source
Spliceosomal Proteins in Plants
2008The spliceosome is a large nuclear structure consisting of dynamically interacting RNAs and proteins. This chapter briefly reviews some of the known components and their interactions. Large-scale proteomics and gene expression studies may be required to unravel the many intricate mechanisms involved in splice site recognition and selection.
Y, Ru, B-B, Wang, V, Brendel
openaire +2 more sources
Spliceosome Assembly and Composition
2007Cells control alternative splicing by modulating assembly of the pre-mRNA splicing machinery at competing splice sites. Therefore, a working knowledge of spliceosome assembly is essential for understanding how alternative splice site choices are achieved.
Arianne J, Matlin, Melissa J, Moore
openaire +2 more sources
Nature Chemical Biology, 2007
The U2 snRNP particle is an essential component of the eukaryotic pre-mRNA splicing apparatus, the spliceosome. Natural and semisynthetic inhibitors that bind the SF3b subunit of the U2 snRNP block splicing and prompt nuclear export of intron-bearing precursors, defining a new mode of action in anticancer drugs.
openaire +1 more source
The U2 snRNP particle is an essential component of the eukaryotic pre-mRNA splicing apparatus, the spliceosome. Natural and semisynthetic inhibitors that bind the SF3b subunit of the U2 snRNP block splicing and prompt nuclear export of intron-bearing precursors, defining a new mode of action in anticancer drugs.
openaire +1 more source