Results 31 to 40 of about 13,573 (214)
Alternative Spliceosome Assembly Pathways Revealed by Single-Molecule Fluorescence Microscopy
Cell Reports, 2013 Removal of introns from nascent transcripts (pre-mRNAs) by the spliceosome is an essential step in eukaryotic gene expression. Previous studies have suggested that the earliest steps in spliceosome assembly in yeast are highly ordered and the stable ...
Inna Shcherbakova +7 more
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The MUC1 extracellular domain subunit is found in nuclear speckles and associates with spliceosomes. [PDF]
PLoS ONE, 2012 MUC1 is a large transmembrane glycoprotein and oncogene expressed by epithelial cells and overexpressed and underglycosylated in cancer cells. The MUC1 cytoplasmic subunit (MUC1-C) can translocate to the nucleus and regulate gene expression.
Priyadarsini Kumar +5 more
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Srsf10 and the minor spliceosome control tissue-specific and dynamic SR protein expression
eLife, 2020 Minor and major spliceosomes control splicing of distinct intron types and are thought to act largely independent of one another. SR proteins are essential splicing regulators mostly connected to the major spliceosome.
Stefan Meinke +6 more
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Hepatology Communications, 2022 CircRNAs have been reported to play crucial roles in tumor progression and recurrence, showing potential as biomarkers in cancer. However, the global abundance of circRNA and their involvement in hepatocellular carcinoma (HCC) development have not been ...
Lei He +11 more
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PLoS Genetics, 2015 Little is known about contacts in the spliceosome between proteins and intron nucleotides surrounding the pre-mRNA branch-site and their dynamics during splicing.
Cornelius Schneider +5 more
semanticscholar +1 more source
SF3b4: A Versatile Player in Eukaryotic Cells
Frontiers in Cell and Developmental Biology, 2020 Spliceosomes are large protein-RNA complexes regulating pre-mRNA processing in eukaryotes. SF3b4 encodes a core subunit of the U2-type spliceosome, loss- or gain-of-function of which often associates with abnormal cell growth, leading to tumorigenesis ...
Feng Xiong, Sha Li, Sha Li
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Splicing diversity revealed by reduced spliceosomes in C. merolae and other organisms
RNA Biology, 2015 Pre-mRNA splicing has been considered one of the hallmarks of eukaryotes, yet its diversity is astonishing: the number of substrate introns for splicing ranges from hundreds of thousands in humans to a mere handful in certain parasites.
A. J. Hudson +4 more
semanticscholar +1 more source
The Natural Product N-Palmitoyl-l-leucine Selectively Inhibits Late Assembly of Human Spliceosomes*
Journal of Biological Chemistry, 2015 Background: Compounds that inhibit spliceosomes are of very limited availability. Results: A high-throughput screen of a marine bacteria natural products library identified a promising lead compound that inhibits pre-mRNA splicing in vitro. Conclusion: N-
Kerstin A. Effenberger +5 more
semanticscholar +1 more source
Surprisingly high number of Twintrons in vertebrates
Biology Direct, 2013 Twintrons represent a special intronic arrangement in which introns of two different types occupy the same gene position. Consequently, alternative splicing of these introns requires two different spliceosomes competing for the same RNA molecule. So far,
Janice Jessin +2 more
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Zrsr2 and functional U12-dependent spliceosome are necessary for follicular development
iScience, 2022 Summary: ZRSR2 is a splicing factor involved in recognition of 3′-intron splice sites that is frequently mutated in myeloid malignancies and several tumors; however, the role of mutations of Zrsr2 in other tissues has not been analyzed.
Isabel Gómez-Redondo +10 more
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