Results 41 to 50 of about 13,573 (214)

Endogenous U2·U5·U6 snRNA complexes in S. pombe are intron lariat spliceosomes

RNA: A publication of the RNA Society, 2014
During logarithmic growth, Schizosaccharomyces pombe cells contain abundant, high-molecular-weight complexes harboring U2, U5, and U6 snRNAs. Chen et al.
Weijun Chen, H. Shulha, Ami Ashar-Patel, Jing Yan, K. Green, C. Query, Nicholas Rhind, Z. Weng, M. Moore   +8 more
semanticscholar   +1 more source

U12 type introns were lost at multiple occasions during evolution

BMC Genomics, 2010
Background Two categories of introns are known, a common U2 type and a rare U12 type. These two types of introns are removed by distinct spliceosomes. The phylogenetic distribution of spliceosomal RNAs that are characteristic of the U12 spliceosome, i.e.
Bartschat Sebastian, Samuelsson Tore
doaj   +1 more source

Aspartyl-tRNA synthetase 2 orchestrates iron-sulfur metabolism in hematopoietic stem cells via fine-tuning alternative RNA splicing

Cell Reports, 2023
Summary: Aspartyl-tRNA synthetase 2 (Dars2) is involved in the regulation of mitochondrial protein synthesis and tissue-specific mitochondrial unfolded protein response (UPRmt).
Xuan Gu, Kailing Li, Meng Zhang, Yandan Chen, Jingchao Zhou, Chunxu Yao, Yong Zang, Jiefeng He, Jun Wan, Bin Guo   +9 more
doaj   +1 more source

Mass spectrometry–based relative quantification of proteins in precatalytic and catalytically active spliceosomes by metabolic labeling (SILAC), chemical labeling (iTRAQ), and label-free spectral count

RNA: A publication of the RNA Society, 2014
The authors present the results of three independent mass spectrometry–based approaches to assess protein composition of precatalytic and catalytic spliceosomes.
Carla Schmidt, M. Grønborg, J. Deckert, Sergey Bessonov, T. Conrad, R. Lührmann, H. Urlaub   +6 more
semanticscholar   +1 more source

Challenging the spliceosome machine [PDF]

Genome Biology, 2006
Abstract Background Using cDNA copies of transcripts and corresponding genomic sequences from the Berkeley Drosophila Genome Project, a set of 24,753 donor and acceptor splice sites were computed with a scanning algorithm that tested for single nucleotide insertion, deletion and substitution ...
Weir, Michael, Eaton, Matthew, Rice, Michael   +2 more
openaire   +2 more sources

Stalled spliceosomes are a signal for RNAi-mediated genome defense.

Cell, 2013
Using the yeast Cryptococcus neoformans, we describe a mechanism by which transposons are initially targeted for RNAi-mediated genome defense. We show that intron-containing mRNA precursors template siRNA synthesis.
Phillip A. Dumesic, Prashanthi Natarajan, Changbin Chen, I. Drinnenberg, B. Schiller, James Thompson, J. Moresco, J. Yates, D. Bartel, H. Madhani   +9 more
semanticscholar   +1 more source

Defective minor spliceosomes induce SMA-associated phenotypes through sensitive intron-containing neural genes in Drosophila

Nature Communications, 2020
Spinal muscular atrophy (SMA) is associated with minor splicing-related defects. Here the authors develop Drosophila models with minor spliceosomal-snRNA deletions, and demonstrate SMA-like phenotypes.
Liang Li, Zhan Ding, Ting-Lin Pang, Bei Zhang, Chen-Hui Li, An-Min Liang, Yu-Ru Wang, Yu Zhou, Yu-Jie Fan, Yong-Zhen Xu   +9 more
doaj   +1 more source

Effects of GYP mRNA alternative splicing on cell surface localization of MNS blood group glycoprotein GPA and GPB

Zhongguo shuxue zazhi, 2022
Objective To analyze the polymorphisms of GYPA and GYPB mRNA spliceosomes associated with MNS blood group, and to explore the mechanism of subcellular localization of GPA and GPB protein isomerism encoded by various spliceosomes as well as the expression
Yanlian LIANG, Yanwen LIANG, Jiansuo LIN, Hongxing WANG, Shuai Chen, Yunping XU   +5 more
doaj   +1 more source

Spliceosome Mutations in Uveal Melanoma [PDF]

International Journal of Molecular Sciences, 2020
Uveal melanoma (UM) is the most common primary intraocular malignancy of the eye. It has a high metastatic potential and mainly spreads to the liver. Genetics play a vital role in tumor classification and prognostication of UM metastatic disease. One of the driver genes mutated in metastasized UM is subunit 1 of splicing factor 3b (SF3B1), a component ...
Josephine Q.N. Nguyen, Wojtek Drabarek, Serdar Yavuzyigitoglu, Eva Medico Salsench, Robert M. Verdijk, Nicole C. Naus, Annelies de Klein, Emine Kiliç, Erwin Brosens   +8 more
openaire   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source