Results 61 to 70 of about 553,332 (236)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Structural insights into lipid membrane binding by human ferlins

The EMBO Journal
Ferlins are ancient membrane proteins with a unique architecture, and play central roles in crucial processes that involve Ca2+-dependent vesicle fusion.
Constantin Cretu, Aleksandar Chernev, Csaba Zoltán Kibédi Szabó, Vladimir Pena, Henning Urlaub, Tobias Moser, Julia Preobraschenski   +6 more
doaj   +1 more source

Structural Correlation Based Method for Image Forgery Classification and Localization

Applied Sciences, 2020
In the image forgery problems, previous works has been chiefly designed considering only one of two forgery types: copy-move and splicing. In this paper, we propose a scheme to handle both copy-move and splicing image forgery by concurrently classifying ...
Nam Thanh Pham, Jong-Weon Lee, Chun-Su Park   +2 more
doaj   +1 more source

A conformational RNA zipper promotes intron ejection during non-conventional XBP1 mRNA splicing. [PDF]

, 2015
The kinase/endonuclease IRE1 is the most conserved signal transducer of the unfolded protein response (UPR), an intracellular signaling network that monitors and regulates the protein folding capacity of the endoplasmic reticulum (ER).
Acosta-Alvear, Diego, Mendez, Aaron S, Peschek, Jirka, Walter, Peter   +3 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Propagation of [D1,2]-type spliceosomal twin introns (stwintrons) in Hypoxylaceae and Xylariaceae fungi

Microbiology Spectrum
[D1,2] stwintrons consist of nested U2 introns, where an internal intron splits the 5′-donor of an external intron between its first and second nucleotide.
Erzsébet Fekete, Norbert Ág, Viktória Ág-Rácz, Alexandra Márton, Erzsébet Sándor, Claudio Scazzocchio, Michel Flipphi, Levente Karaffa   +7 more
doaj   +1 more source

Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer

Frontiers in Genetics, 2023
N6-methyladenosine (m6A) is the most abundant internal mRNA modification and is dynamically regulated through distinct protein complexes that methylate, demethylate, and/or interpret the m6A modification.
Jennifer Lothion-Roy, Jennifer Lothion-Roy, Daisy B. Haigh, Daisy B. Haigh, Anna E. Harris, Anna E. Harris, Veronika M. Metzler, Mansour Alsaleem, Mansour Alsaleem, Mansour Alsaleem, Michael S. Toss, Michael S. Toss, Yousif Kariri, Yousif Kariri, Yousif Kariri, Atara Ntekim, Atara Ntekim, Brian D. Robinson, Francesca Khani, Lorraine J. Gudas, Cinzia Allegrucci, Cinzia Allegrucci, Victoria H. James, Victoria H. James, Srinivasan Madhusudan, Srinivasan Madhusudan, Melissa Mather, Richard D. Emes, Nathan Archer, Rupert G. Fray, Emad Rakha, Jennie N. Jeyapalan, Jennie N. Jeyapalan, Catrin S. Rutland, Nigel P. Mongan, Nigel P. Mongan, Nigel P. Mongan, Corinne L. Woodcock, Corinne L. Woodcock   +38 more
doaj   +1 more source

SRSF2 Is Essential For Hematopoiesis and Its Mutations Dysregulate Alternative RNA Splicing In MDS [PDF]

, 2013
Myelodysplastic syndromes (MDS) are a group of neoplasms that are ineffective in generating multiple lineages of myeloid cells and have various risks to progress to acute myeloid leukemia.
Chen, Liang, Dekelver, Russell, Fu, Xiang-Dong, Heuser, Michael, Komeno, Yukiko, Lin, Leo, Monterroza, Dora D, Qiu, Jinsong, Thol, Felicitas, Xu, YiJun, Zhang, Dong-Er   +10 more
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

ResTran: Long Distance Relationship on Image Forgery Detection

IEEE Access, 2023
Image tampering detection is becoming more and more important in image forensics, especially in today’s society where advanced image editing tools are becoming more and more popular.
Jingjing Rao, Songpon Teerakanok, Tetsutaro Uehara   +2 more
doaj   +1 more source