Results 1 to 10 of about 208,874 (142)

Split-APEX implicates splicing factor SRSF1 and splicing helicases in ribosomal biogenesis [PDF]

Frontiers in Molecular Biosciences
SR proteins are RNA-binding proteins with one or two RNA recognition motif (RRM)-type RNA-binding domains and a C-terminal region rich in arginine-serine dipeptides. They function in cellular processes ranging from transcription to translation.
Vasileios Paschalis, Vasileios Paschalis, Max F. K. Wills, Max F. K. Wills, Philippe De Gusmao Araujo, Philippe De Gusmao Araujo, Christian Lucas, Christian Lucas, Sumera Tubasum, Sumera Tubasum, Shijie Cui, Shijie Cui, Hesna Kara, Hesna Kara, Carlos Bueno-Alejo, Carlos Bueno-Alejo, Marina Santana-Vega, Andrea Taladriz-Sender, Zhengyun Zhao, Alexander Axer, Cyril Dominguez, Cyril Dominguez, Alasdair W. Clark, Glenn A. Burley, Andrew J. Hudson, Andrew J. Hudson, Ian C. Eperon, Ian C. Eperon   +27 more
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Lamin B1 regulates RNA splicing factor expression by modulating the spatial positioning and chromatin interactions of the ETS1 gene locus [PDF]

Animal Cells and Systems
Lamin B1, a crucial component of the nuclear lamina, plays a pivotal role in chromatin organization and transcriptional regulation in eukaryotic cells. While recent studies have highlighted the connection between Lamin B1 and RNA splicing regulation, the
Geun-Seup Shin, Ah-Ra Jo, Jinho Kim, Ji-Young Kim, Chul-Hong Kim, Mi-Jin An, Hyun-Min Lee, Yuna Park, Yujeong Hwangbo, Jung-Woong Kim   +9 more
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Serine and arginine rich splicing factor 1: a potential target for neuroprotection and other diseases

Neural Regeneration Research, 2023
Alternative splicing is the process of producing variably spliced mRNAs by choosing distinct combinations of splice sites within a messenger RNA precursor.
Ana M Sandoval-Castellanos, Anushka Bhargava, Min Zhao, Jun Xu, Ke Ning   +4 more
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The mutation in splicing factor genes correlates with unfavorable prognosis, genomic instability, anti-tumor immunosuppression and increased immunotherapy response in pan-cancer

Frontiers in Cell and Developmental Biology, 2023
Splicing abnormality resulting from somatic mutations in key splicing factor genes (SFG) has been detected in various cancers. Hence, an in-depth study of splicing factor genes mutations’ impact on pan-cancer is meaningful.
Jiangti Luo, Jiangti Luo, Jiangti Luo, Canping Chen, Canping Chen, Canping Chen, Zhixian Liu, Xiaosheng Wang, Xiaosheng Wang, Xiaosheng Wang   +9 more
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SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity

Nature Communications, 2021
Splicing factor PTBP1 is reported to promote oncogenic functions in glioblastoma (GBM). Here the authors show splicing factor SON upregulates PTBP1 expression while supresses its paralog PTBP2 through alternative splicing and the inhibition of SON ...
Jung-Hyun Kim, Kyuho Jeong, Jianfeng Li, James M. Murphy, Lana Vukadin, Joshua K. Stone, Alexander Richard, Johnny Tran, G. Yancey Gillespie, Erik K. Flemington, Robert W. Sobol, Ssang-Teak Steve Lim, Eun-Young Erin Ahn   +12 more
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RNA-Binding Proteins Hold Key Roles in Function, Dysfunction, and Disease

Biology, 2021
RNA-binding proteins (RBPs) are multi-faceted proteins in the regulation of RNA or its RNA splicing, localisation, stability, and translation. Amassing proof from many recent and dedicated studies reinforces the perception of RBPs exerting control ...
Sophia Kelaini, Celine Chan, Victoria A Cornelius, Andriana Margariti   +3 more
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Comprehensive Analysis of Splicing Factor and Alternative Splicing Event to Construct Subtype-Specific Prognosis-Predicting Models for Breast Cancer

Frontiers in Genetics, 2021
Recent evidence suggests that splicing factors (SFs) and alternative splicing (AS) play important roles in cancer progression. We constructed four SF-risk-models using 12 survival-related SFs.
He Zhang, He Zhang, He Zhang, He Zhang, Baoai Han, Baoai Han, Baoai Han, Baoai Han, Xingxing Han, Xingxing Han, Xingxing Han, Xingxing Han, Yuying Zhu, Yuying Zhu, Yuying Zhu, Yuying Zhu, Hui Liu, Hui Liu, Hui Liu, Hui Liu, Zhiyong Wang, Zhiyong Wang, Zhiyong Wang, Zhiyong Wang, Yanfen Cui, Yanfen Cui, Yanfen Cui, Yanfen Cui, Ran Tian, Ran Tian, Ran Tian, Ran Tian, Zicong Gao, Zicong Gao, Zicong Gao, Zicong Gao, Ruinan Tian, Ruinan Tian, Ruinan Tian, Ruinan Tian, Sixin Ren, Sixin Ren, Sixin Ren, Sixin Ren, Xiaoyan Zuo, Xiaoyan Zuo, Xiaoyan Zuo, Xiaoyan Zuo, Jianfei Tian, Jianfei Tian, Jianfei Tian, Jianfei Tian, Fei Zhang, Fei Zhang, Fei Zhang, Fei Zhang, Ruifang Niu, Ruifang Niu, Ruifang Niu, Ruifang Niu   +59 more
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Oncogenic KRAS alters splicing factor phosphorylation and alternative splicing in lung cancer

BMC Cancer, 2022
Background Alternative RNA splicing is widely dysregulated in cancers including lung adenocarcinoma, where aberrant splicing events are frequently caused by somatic splice site mutations or somatic mutations of splicing factor genes.
April Lo, Maria McSharry, Alice H. Berger   +2 more
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SWELLMAP 2, a phyB-Interacting Splicing Factor, Negatively Regulates Seedling Photomorphogenesis in Arabidopsis

Frontiers in Plant Science, 2022
Light-triggered transcriptome reprogramming is critical for promoting photomorphogenesis in Arabidopsis seedlings. Nonetheless, recent studies have shed light on the importance of alternative pre-mRNA splicing (AS) in photomorphogenesis.
Tingting Yan, Tingting Yan, Yueqin Heng, Wenwei Wang, Jian Li, Xing Wang Deng, Xing Wang Deng   +6 more
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An overview of RNA splicing and functioning of splicing factors in land plant chloroplasts

RNA Biology, 2022
RNA splicing refers to a process by which introns of a pre-mRNA are excised and the exons at both ends are joined together. Chloroplast introns are inherently self-splicing ribozymes, but over time, they have lost self-splicing ability due to the ...
Xuemei Wang, Jingyi Wang, Simin Li, Congming Lu, Na Sui   +4 more
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