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Splicing-factor alterations in cancers [PDF]

RNA, 2016
Tumor-associated alterations in RNA splicing result either from mutations in splicing-regulatory elements or changes in components of the splicing machinery. This review summarizes our current understanding of the role of splicing-factor alterations in human cancers.
AnczukÃ³w, Olga, Krainer, Adrian R
openaire +4 more sources

Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types [PDF]

Cell Reports, 2018
Summary: Hotspot mutations in splicing factor genes have been recently reported at high frequency in hematological malignancies, suggesting the importance of RNA splicing in cancer.
Michael Seiler +733 more
doaj +3 more sources

Control of pre-mRNA splicing by the general splicing factors PUF60 and U2AF(65). [PDF]

PLoS ONE, 2007
Pre-mRNA splicing is a crucial step in gene expression, and accurate recognition of splice sites is an essential part of this process. Splice sites with weak matches to the consensus sequences are common, though it is not clear how such sites are ...
Michelle L Hastings +4 more
doaj +3 more sources

Splicing factor SRSF6 mediates pleural fibrosis [PDF]

JCI Insight, 2021
Pleural fibrosis is defined as an excessive deposition of extracellular matrix that results in destruction of the normal pleural tissue architecture and compromised function.
Li-Mei Liang +15 more
doaj +3 more sources

CRISPR artificial splicing factors [PDF]

Nature Communications, 2020
Abstract Alternative splicing allows expression of mRNA isoforms from a single gene, expanding the diversity of the proteome. Its prevalence in normal biological and disease processes warrant precise tools for modulation.
Menghan Du +4 more
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Processive phosphorylation of alternative splicing factor/splicing factor 2 [PDF]

Proceedings of the National Academy of Sciences, 2003
SR proteins, named for their multiple arginine/serine (RS) dipeptide repeats, are critical components of the spliceosome, influencing both constitutive and alternative splicing of pre-mRNA. SR protein function is regulated through phosphorylation of their RS domains by multiple kinases, including a family of evolutionarily conserved SR protein-specific
Brandon E, Aubol +7 more
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Splicing factor mutations in hematologic malignancies [PDF]

Blood, 2021
Abstract Mutations in genes encoding RNA splicing factors were discovered nearly 10 years ago and are now understood to be among the most recurrent genetic abnormalities in patients with all forms of myeloid neoplasms and several types of lymphoproliferative disorders, as well as subjects with clonal hematopoiesis.
Sisi Chen, Salima Benbarche, Omar Abdel-Wahab +2 more
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Splicing factor SRSF2-centric gene regulation [PDF]

International Journal of Biological Sciences, 2021
Serine/arginine-rich splicing factor 2 (SRSF2) is a splicing factor that is widely expressed in a variety of mammalian cell types. Increasing evidence has confirmed that SRSF2 plays vital roles in a number of biological and pathological processes.
Li, Kun, Wang, Ziqiang
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Splicing factor mutations and cancer [PDF]

WIREs RNA, 2014
Recent advances in high‐throughput sequencing technologies have unexpectedly revealed that somatic mutations of splicing factor genes frequently occurred in several types of hematological malignancies, including myelodysplastic syndromes, other myeloid neoplasms, and chronic lymphocytic leukemia.
Yoshida, Kenichi, Ogawa, Seishi
openaire +2 more sources

SWELLMAP 2, a phyB-Interacting Splicing Factor, Negatively Regulates Seedling Photomorphogenesis in Arabidopsis

Frontiers in Plant Science, 2022
Light-triggered transcriptome reprogramming is critical for promoting photomorphogenesis in Arabidopsis seedlings. Nonetheless, recent studies have shed light on the importance of alternative pre-mRNA splicing (AS) in photomorphogenesis.
Tingting Yan +6 more
doaj +1 more source

rna splicing
genetics
rna

alternative splicing
cell biology
exon

computational biology
molecular biology
cancer research