Splicing factor - Open Access .click

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Comprehensive Analysis of Prognostic Alternative Splicing Signature Reveals Recurrence Predictor for Papillary Thyroid Cancer

Frontiers in Oncology, 2021
BackgroundAlternative splicing (AS) plays a key role in the diversity of proteins and is closely associated with tumorigenicity. The aim of this study was to systemically analyze RNA alternative splicing (AS) and identify its prognostic value for ...
Mian Liu +12 more
doaj +1 more source

Screening and Identification of Survival-Associated Splicing Factors in Lung Squamous Cell Carcinoma

Frontiers in Genetics, 2022
Lung squamous cell carcinoma (LUSC) is a disease with high morbidity and mortality. Many studies have shown that aberrant alternative splicing (AS) can lead to tumorigenesis, and splicing factors (SFs) serve as an important function during AS.
Min Chen +4 more
doaj +1 more source

Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types

Cell Reports, 2018
Summary: Hotspot mutations in splicing factor genes have been recently reported at high frequency in hematological malignancies, suggesting the importance of RNA splicing in cancer.
Michael Seiler +733 more
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Identification of the prognostic signature based on genomic instability-related alternative splicing in colorectal cancer and its regulatory network

Frontiers in Bioengineering and Biotechnology, 2022
Background: Colorectal cancer (CRC) is a heterogeneous disease with many somatic mutations defining its genomic instability. Alternative Splicing (AS) events, are essential for maintaining genomic instability.
Qiuying Ding +5 more
doaj +1 more source

SF3B4 is decreased in pancreatic cancer and inhibits the growth and migration of cancer cells

Tumor Biology, 2017
Splicing factor 3b subunit 4, a critical component of pre-message RNA splicing complex, has been reported to play an important part in the tumorigenesis.
Wentao Zhou +10 more
doaj +1 more source

Spliceosomal components protect embryonic neurons from R-loop-mediated DNA damage and apoptosis

Disease Models & Mechanisms, 2018
RNA splicing factors are essential for the viability of all eukaryotic cells; however, in metazoans some cell types are exquisitely sensitive to disruption of splicing factors.
Shelly Sorrells +10 more
doaj +1 more source

Targeting splicing factors for cancer therapy

RNA, 2023
Alternative splicing (AS) of mRNAs is an essential regulatory mechanism in eukaryotic gene expression. AS misregulation, caused by either dysregulation or mutation of splicing factors, has been shown to be involved in cancer development and progression, making splicing factors suitable targets for cancer therapy.
Ariel Bashari, Zahava Siegfried, Rotem Karni +2 more
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Systematic Analyses of the Differentially Expressed Alternative Splicing Events in Gastric Cancer and Its Clinical Significance

Frontiers in Genetics, 2020
Accumulation of evidence has indicated a close relationship between alternative splicing (AS) and gastric cancer (GC), whereas systematic analyses of the differentially expressed AS events (DEAS) between GC and normal tissues are lacking.
Changwei Lin +6 more
doaj +1 more source

Splicing factor mutations in myelodysplasia [PDF]

International Journal of Hematology, 2012
Myelodysplastic syndromes (MDS) and related myeloid neoplasms are a heterogeneous group of myeloid neoplasms, which frequently terminate in acute myeloid leukemia (AML). During the past decade, a number of gene mutations have been identified in MDS.
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Engineering splicing factors with designed specificities [PDF]

Nature Methods, 2009
Alternative splicing is generally regulated by trans-acting factors that specifically bind pre-mRNA to activate or inhibit the splicing reaction. This regulation is critical for normal gene expression, and dysregulation of splicing is closely associated with human diseases. Here we engineer artificial splicing factors by combining sequence-specific RNA-
Yang, Wang +3 more
openaire +2 more sources

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