Results 31 to 40 of about 208,874 (142)

Availability of splicing factors in the nucleoplasm can regulate the release of mRNA from the gene after transcription.

PLoS Genetics, 2019
Gene expression dynamics can be measured in single living cells. Using a detectable transcriptionally active gene in living cells, we previously found that an mRNA undergoing several splicing events was retained at this gene after transcription until ...
Hodaya Hochberg-Laufer, Noa Neufeld, Yehuda Brody, Shani Nadav-Eliyahu, Rakefet Ben-Yishay, Yaron Shav-Tal   +5 more
doaj   +1 more source

Alternative splicing regulation during C. elegans development: splicing factors as regulated targets. [PDF]

PLoS Genetics, 2008
Alternative splicing generates protein diversity and allows for post-transcriptional gene regulation. Estimates suggest that 10% of the genes in Caenorhabditis elegans undergo alternative splicing. We constructed a splicing-sensitive microarray to detect
Sergio Barberan-Soler, Alan M Zahler
doaj   +1 more source

Functional roles of protein splicing factors [PDF]

Bioscience Reports, 2012
RNA splicing is one of the fundamental processes in gene expression in eukaryotes. Splicing of pre-mRNA is catalysed by a large ribonucleoprotein complex called the spliceosome, which consists of five small nuclear RNAs and numerous protein factors. The spliceosome is a highly dynamic structure, assembled by sequential binding and release of the small ...
Chen, Hsin-Chou, Cheng, Soo-Chen
openaire   +2 more sources

Splicing factor Prp18p promotes genome-wide fidelity of consensus 3′-splice sites [PDF]

Nucleic Acids Research, 2023
Abstract The fidelity of splice site selection is critical for proper gene expression. In particular, proper recognition of 3′-splice site (3′SS) sequences by the spliceosome is challenging considering the low complexity of the 3′SS consensus sequence YAG. Here, we show that absence of the Prp18p splicing factor results in genome-wide
Kevin R Roy, Jason Gabunilas, Dean Neutel, Michelle Ai, Zoe Yeh, Joyce Samson, Guochang Lyu, Guillaume F Chanfreau   +7 more
openaire   +3 more sources

Alternative Splicing Events and Splicing Factors Are Prognostic in Adrenocortical Carcinoma [PDF]

Frontiers in Genetics, 2020
Alternative splicing is involved in the pathogenesis of human diseases, including cancer. Here, we investigated the potential application of alternative splicing events (ASEs) and splicing factors (SFs) in the prognosis of adrenocortical carcinoma (ACC).
Jian Lv, Jian Lv, Yuan He, Lili Li, Zhihua Wang, Zhihua Wang   +5 more
openaire   +3 more sources

Control of pre-mRNA splicing by the general splicing factors PUF60 and U2AF(65). [PDF]

PLoS ONE, 2007
Pre-mRNA splicing is a crucial step in gene expression, and accurate recognition of splice sites is an essential part of this process. Splice sites with weak matches to the consensus sequences are common, though it is not clear how such sites are ...
Michelle L Hastings, Eric Allemand, Dominik M Duelli, Michael P Myers, Adrian R Krainer   +4 more
doaj   +1 more source

Splicing factor PTBP1 promotes hepatocarcinogenesis via oncogenic splice-switching of MAPT. [PDF]

Oncol Res
Alterations in splicing factors contribute to aberrant alternative splicing (AS), which subsequently promotes tumor progression. The splicing factor polypyrimidine tract binding protein 1 (PTBP1) has been shown to facilitate cancer progression by modulating oncogenic variants.
Zheng W, Shang Y, DU K, Luo A, Pei L, Li M, Zhang G, Deng M.   +7 more
europepmc   +3 more sources

Aurora kinase A regulates cancer-associated RNA aberrant splicing in breast cancer

Heliyon, 2023
The contribution of oncogenes to tumor-associated RNA splicing and the relevant molecular mechanisms therein require further elaboration. Here, we show that oncogenic Aurora kinase A (AURKA) promotes breast cancer-related RNA aberrant splicing in a ...
Sisi Li, Yangfan Qi, Jiachuan Yu, Yuchao Hao, Lingzhi Xu, Xudong Ding, Minghui Zhang, Jingshu Geng   +7 more
doaj   +1 more source

Intronic splicing enhancers, cognate splicing factors and context-dependent regulation rules [PDF]

Nature Structural & Molecular Biology, 2012
SummaryMost human genes produce multiple splicing isoforms with distinct functions. To systematically understand splicing regulation, we conducted an unbiased screen and identified >100 intronic splicing enhancers (ISEs) that were clustered by sequence similarity into six groups.
Wang, Yang, Ma, Meng, Xiao, Xinshu, Wang, Zefeng   +3 more
openaire   +2 more sources

A novel Splicing Factor that Affects Titin Alternative Splicing [PDF]

Biophysical Journal, 2011
Cardiac muscle expresses predominantly larger N2BA titin isoforms at embryonic and prenatal stages of development, and these are mostly replaced with a smaller N2B isoform in adults. We have previously discovered a mutation in rats that dramatically alters titin splicing (Greaser et al J Mol Cell Cardiol 44:982, 2008).
Guo, Wei, Greaser, Marion, Li, Shijun, Schulz, Herbert, Saar, Kathrin, Radke, Michael, Hacker, Timothy A., Saupe, Kurt W., Vakeel, Padmanabhan, Govindarajan, Thirupugal, Hubner, Norbert, Gotthardt, Michael   +11 more
openaire   +1 more source