A conformational RNA zipper promotes intron ejection during non-conventional XBP1 mRNA splicing. [PDF]
, 2015 The kinase/endonuclease IRE1 is the most conserved signal transducer of the unfolded protein response (UPR), an intracellular signaling network that monitors and regulates the protein folding capacity of the endoplasmic reticulum (ER).
Acosta-Alvear, Diego +3 more
core +1 more source
SF3B4 is decreased in pancreatic cancer and inhibits the growth and migration of cancer cells
Tumor Biology, 2017 Splicing factor 3b subunit 4, a critical component of pre-message RNA splicing complex, has been reported to play an important part in the tumorigenesis.
Wentao Zhou +10 more
doaj +1 more source
Spliceosomal components protect embryonic neurons from R-loop-mediated DNA damage and apoptosis
Disease Models & Mechanisms, 2018 RNA splicing factors are essential for the viability of all eukaryotic cells; however, in metazoans some cell types are exquisitely sensitive to disruption of splicing factors.
Shelly Sorrells +10 more
doaj +1 more source
Retinal pigment epithelium degeneration caused by aggregation of PRPF31 and the role of HSP70 family of proteins [PDF]
, 2020 Background Mutations in pre-mRNA splicing factor PRPF31 can lead to retinitis pigmentosa (RP). Although the exact disease mechanism remains unknown, it has been hypothesized that haploinsufficiency might be involved in the ...
Aramburu, Ana +13 more
core +2 more sources
Splicing factor PTBP1 promotes hepatocarcinogenesis via oncogenic splice-switching of MAPT. [PDF]
Oncol ResAlterations in splicing factors contribute to aberrant alternative splicing (AS), which subsequently promotes tumor progression. The splicing factor polypyrimidine tract binding protein 1 (PTBP1) has been shown to facilitate cancer progression by modulating oncogenic variants.
Zheng W +7 more
europepmc +3 more sources
Targeting splicing factors for cancer therapy
RNA, 2023 Alternative splicing (AS) of mRNAs is an essential regulatory mechanism in eukaryotic gene expression. AS misregulation, caused by either dysregulation or mutation of splicing factors, has been shown to be involved in cancer development and progression, making splicing factors suitable targets for cancer therapy.
Ariel Bashari +2 more
openaire +2 more sources
Mud2 functions in transcription by recruiting the Prp19 and TREX complexes to transcribed genes [PDF]
, 2007 The different steps of gene expression are intimately linked to coordinate and regulate this complex process. During transcription, numerous RNA-binding proteins are already loaded onto the nascent mRNA and package the mRNA into a messenger ...
Andersen, Ulrik L. +8 more
core +1 more source
Frontiers in Genetics, 2020 Accumulation of evidence has indicated a close relationship between alternative splicing (AS) and gastric cancer (GC), whereas systematic analyses of the differentially expressed AS events (DEAS) between GC and normal tissues are lacking.
Changwei Lin +6 more
doaj +1 more source
The CUGBP2 splicing factor regulates an ensemble of branchpoints from perimeter binding sites with implications for autoregulation [PDF]
, 2009 Alternative pre-mRNA splicing adjusts the transcriptional output of the genome by generating related mRNAs from a single primary transcript, thereby expanding protein diversity.
Dembowski, JA, Grabowski, PJ
core +5 more sources
Splicing factor mutations in myelodysplasia [PDF]
International Journal of Hematology, 2012 Myelodysplastic syndromes (MDS) and related myeloid neoplasms are a heterogeneous group of myeloid neoplasms, which frequently terminate in acute myeloid leukemia (AML). During the past decade, a number of gene mutations have been identified in MDS.
openaire +2 more sources