Results 41 to 50 of about 208,874 (142)
Small molecule amiloride modulates oncogenic RNA alternative splicing to devitalize human cancer cells. [PDF]
PLoS ONE, 2011 Alternative splicing involves differential exon selection of a gene transcript to generate mRNA and protein isoforms with structural and functional diversity.
Jan-Gowth Chang +9 more
doaj +1 more source
Splicing factor hnRNPH drives an oncogenic splicing switch in gliomas.
The EMBO journal, 2011 In tumours, aberrant splicing generates variants that contribute to multiple aspects of tumour establishment, progression and maintenance. We show that in glioblastoma multiforme (GBM) specimens, death-domain adaptor protein Insuloma-Glucagonoma protein 20 (IG20) is consistently aberrantly spliced to generate an antagonist, anti-apoptotic isoform (MAP ...
LeFave, Clare V +7 more
openaire +2 more sources
Aurora-A phosphorylates splicing factors and regulates alternative splicing [PDF]
, 2020 ABSTRACTAurora-A kinase is well known to regulate progression through mitosis. However, the kinase also performs additional functions that could explain the failure of its inhibitors to be effective in cancer treatments. To identify these functions, we applied a proteomics approach to search for interactors of Aurora-A.
Arun Prasath Damodaran +11 more
openaire +1 more source
Alterations of RNA splicing patterns in esophagus squamous cell carcinoma
Cell & Bioscience, 2021 Alternative splicing (AS) is an important biological process for regulating the expression of various isoforms from a single gene and thus to promote proteome diversity.
Jiyu Ding +13 more
doaj +1 more source
The regulatory role of alternative splicing in inflammatory bowel disease
Frontiers in Immunology, 2023 Inflammatory bowel disease (IBD) mainly includes Crohn’s disease and ulcerative colitis. These diseases have a progressive course of chronic relapse and remission and affect a large number of children and adults worldwide.
Jianli Zhou +8 more
doaj +1 more source
Wiskott-Aldrich syndrome protein forms nuclear condensates and regulates alternative splicing
Nature Communications, 2022 Wiskott-Aldrich syndrome is caused by mutations in WASP, but the underlying mechanisms remain to be explored. Here the authors reveal that WASP deficiency results in aberrant RNA splicing, and that WASP regulates the transcription of splicing factor ...
Baolei Yuan +35 more
doaj +1 more source
Control of 3' splice site selection by the yeast splicing factor Fyv6. [PDF]
ElifeABSTRACT Pre-mRNA splicing is catalyzed in two steps: 5ʹ splice site (SS) cleavage and exon ligation. A number of proteins transiently associate with spliceosomes to specifically impact these steps (1 st and 2 nd step factors).
Senn KA +5 more
europepmc +5 more sources
Scientific ReportsGerminal center B cells play a pivotal role in the generation of long-lived plasma cells and high-affinity antibodies. Although RNA splicing and alternative splicing are known to regulate germinal center B cell responses, the upstream mechanisms ...
Silu Li +7 more
doaj +1 more source
Regulation of alternative splicing by p300-mediated acetylation of splicing factors [PDF]
RNA, 2019 Splicing of precursor mRNA (pre-mRNA) is an important regulatory step in gene expression. Recent evidence points to a regulatory role of chromatin-related proteins in alternative splicing regulation. Using an unbiased approach, we have identified the acetyltransferase p300 as a key chromatin-related regulator of alternative splicing.
Siam, Ahmad +13 more
openaire +2 more sources
RNPS1 in PSAP complex controls periodic pre-mRNA splicing over the cell cycle
iScienceSummary: Cell cycle progression requires periodic gene expression through splicing control. However, the splicing factor that directly controls this cell cycle-dependent splicing remains unknown.
Kazuhiro Fukumura +6 more
doaj +1 more source