Results 51 to 60 of about 208,874 (142)
eLife, 2017 MECP2 mutations underlying Rett syndrome cause widespread misregulation of gene expression. Functions for MeCP2 other than transcriptional are not well understood.
Zhaoqing Zheng +2 more
doaj +1 more source
hnRNP A1 in RNA metabolism regulation and as a potential therapeutic target
Frontiers in Pharmacology, 2022 Abnormal RNA metabolism, regulated by various RNA binding proteins, can have functional consequences for multiple diseases. Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is an important RNA binding protein, that regulates various RNA metabolic ...
Jianguo Feng +7 more
doaj +1 more source
Splicing factor SRSF1 negatively regulates alternative splicing of MDM2 under damage [PDF]
Nucleic Acids Research, 2015 Genotoxic stress induces alternative splicing of the oncogene MDM2 generating MDM2-ALT1, an isoform attributed with tumorigenic properties. However, the mechanisms underlying this event remain unclear. Here we explore MDM2 splicing regulation by utilizing a novel minigene that mimics endogenous MDM2 splicing in response to UV and cisplatinum-induced ...
Comiskey, Daniel F. +4 more
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BMC Cell Biology, 2017 Background Altered expression of mRNA splicing factors occurs with ageing in vivo and is thought to be an ageing mechanism. The accumulation of senescent cells also occurs in vivo with advancing age and causes much degenerative age-related pathology ...
Eva Latorre +10 more
doaj +1 more source
Splicing factor SRSF1 promotes gliomagenesis via oncogenic splice-switching of MYO1B [PDF]
Journal of Clinical Investigation, 2019 Abnormal alternative splicing (AS) caused by alterations to splicing factors contributes to tumor progression. Serine/arginine splicing factor 1 (SRSF1) has emerged as a key oncodriver in numerous solid tumors, leaving its roles and mechanisms largely obscure in glioma.
Xuexia Zhou +12 more
openaire +2 more sources
Reversible phosphorylation differentially affects nuclear and cytoplasmic functions of splicing factor 2/alternative splicing factor [PDF]
Proceedings of the National Academy of Sciences, 2005 The Ser/Arg-rich (SR) proteins constitute a family of highly conserved nuclear phosphoproteins that are involved in many steps of mRNA metabolism. Previously, we demonstrated that shuttling SR proteins can associate with translating ribosomes and enhance translation of reporter mRNAs both in vivo
Jeremy R, Sanford +3 more
openaire +2 more sources
PHD finger protein 5A promoted lung adenocarcinoma progression via alternative splicing
Cancer Medicine, 2019 Alternative splicing (AS) and the regulation of AS by splicing factors play critical roles in cancer. Plant homeodomain (PHD)–finger domain protein PHF5A, a critical splicing factor involved in AS, has been demonstrated to play an oncogenic role in ...
Shuangshuang Mao +11 more
doaj +1 more source
Systematic Profiling of Alternative Splicing Events in Ovarian Cancer
Frontiers in Oncology, 2021 Alternative splicing (AS) is significantly related to the development of tumor and the clinical outcome of patients. In this study, our aim was to systematically analyze the survival-related AS signal in ovarian serous cystadenocarcinoma (OV) and ...
Jia Liu +4 more
doaj +1 more source
Disease Models & Mechanisms, 2020 Retinitis pigmentosa (RP) represents genetically heterogeneous and clinically variable disease characterized by progressive degeneration of photoreceptors resulting in a gradual loss of vision.
Dimitrije Stanković +4 more
doaj +1 more source
Cell Reports, 2019 Summary: In the eukaryotic cell, spliceosomes assemble onto pre-mRNA cotranscriptionally. Spliceosome assembly takes place in the context of the chromatin environment, suggesting that the state of the chromatin may affect splicing.
Calvin S. Leung +6 more
doaj +1 more source