Aurora kinase A regulates cancer-associated RNA aberrant splicing in breast cancer
Heliyon, 2023 The contribution of oncogenes to tumor-associated RNA splicing and the relevant molecular mechanisms therein require further elaboration. Here, we show that oncogenic Aurora kinase A (AURKA) promotes breast cancer-related RNA aberrant splicing in a ...
Sisi Li +7 more
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Intronic splicing enhancers, cognate splicing factors and context-dependent regulation rules [PDF]
Nature Structural & Molecular Biology, 2012 SummaryMost human genes produce multiple splicing isoforms with distinct functions. To systematically understand splicing regulation, we conducted an unbiased screen and identified >100 intronic splicing enhancers (ISEs) that were clustered by sequence similarity into six groups.
Wang, Yang +3 more
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The Caenorhabditis elegans Gene mfap-1 Encodes a Nuclear Protein That Affects Alternative Splicing [PDF]
, 2012 RNA splicing is a major regulatory mechanism for controlling eukaryotic gene expression. By generating various splice isoforms from a single pre–mRNA, alternative splicing plays a key role in promoting the evolving complexity of metazoans.
A Casrouge +56 more
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A novel Splicing Factor that Affects Titin Alternative Splicing [PDF]
Biophysical Journal, 2011 Cardiac muscle expresses predominantly larger N2BA titin isoforms at embryonic and prenatal stages of development, and these are mostly replaced with a smaller N2B isoform in adults. We have previously discovered a mutation in rats that dramatically alters titin splicing (Greaser et al J Mol Cell Cardiol 44:982, 2008).
Guo, Wei +11 more
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A splicing-dependent transcriptional checkpoint associated with prespliceosome formation [PDF]
, 2014 There is good evidence for functional interactions between splicing and transcription in eukaryotes, but how and why these processes are coupled remain unknown.
Ahn +62 more
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Small molecule amiloride modulates oncogenic RNA alternative splicing to devitalize human cancer cells. [PDF]
PLoS ONE, 2011 Alternative splicing involves differential exon selection of a gene transcript to generate mRNA and protein isoforms with structural and functional diversity.
Jan-Gowth Chang +9 more
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Splicing factor hnRNPH drives an oncogenic splicing switch in gliomas.
The EMBO journal, 2011 In tumours, aberrant splicing generates variants that contribute to multiple aspects of tumour establishment, progression and maintenance. We show that in glioblastoma multiforme (GBM) specimens, death-domain adaptor protein Insuloma-Glucagonoma protein 20 (IG20) is consistently aberrantly spliced to generate an antagonist, anti-apoptotic isoform (MAP ...
LeFave, Clare V +7 more
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Aurora-A phosphorylates splicing factors and regulates alternative splicing [PDF]
, 2020 ABSTRACTAurora-A kinase is well known to regulate progression through mitosis. However, the kinase also performs additional functions that could explain the failure of its inhibitors to be effective in cancer treatments. To identify these functions, we applied a proteomics approach to search for interactors of Aurora-A.
Arun Prasath Damodaran +11 more
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Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans [PDF]
, 2017 This is the final version of the article. Available from the publisher via the DOI in this record.Dysregulation of splicing factor expression and altered alternative splicing are associated with aging in humans and other species, and also with ...
Emond, F +10 more
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Alterations of RNA splicing patterns in esophagus squamous cell carcinoma
Cell & Bioscience, 2021 Alternative splicing (AS) is an important biological process for regulating the expression of various isoforms from a single gene and thus to promote proteome diversity.
Jiyu Ding +13 more
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