Results 251 to 260 of about 215,491 (295)

A Robust Deep Temporal Causal Discovery Platform for Single‐Cell Gene Regulatory Network Reconstruction

Advanced Intelligent Discovery, EarlyView.
scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta, Madison Dautle, Shaoqiang Zhang, Yong Chen   +3 more
wiley   +1 more source

Gate‐Align‐SED: Semi‐Supervised Sound Event Detection via Adaptive Feature Gating and Cross‐Task Alignment in Situation Awareness

Advanced Intelligent Systems, EarlyView.
Overview of the proposed Gate‐Align‐SED, including two stages of training: (1) Mean‐Teacher SSL Training; and (2) Enhancer Model Training. In complex real‐world environments such as disaster monitoring, effective sound event detection (SED) is often hindered by the presence of noise and limited labeled data.
Jieli Chen, Li‐Minn Ang, Chee Shen Lim, Kah Phooi Seng, Jeremy Smith   +4 more
wiley   +1 more source

Therapeutic Silencing of Tmprss6 Reduces Iron‐Induced Inflammation and Prolongs Survival in MDS Mice

American Journal of Hematology, EarlyView.
ABSTRACT Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic disorders characterized by ineffective hematopoiesis, cytopenias, and an increased risk of progression to acute myeloid leukemia (AML). Despite advances in supportive and targeted therapies, disease‐modifying interventions remain limited.
Shahla Vilcassim, Nuttanan Pholngam, Rattanawan Thubthed, Tiwaporn Nualkaew, Saovaros Svasti, Pornthip Chaichompoo, Kai Kysenius, Peter J. Crouch, Sibylle Dames, Mona Eisermann, Alberto Martinez, Ute Schaeper, Jim Vadolas, George Grigoriadis   +13 more
wiley   +1 more source

Therapeutic Outcomes in VEXAS Syndrome: A Multicenter Comparative Cohort of Allogeneic Hematopoietic Stem Cell Transplantation and Hypomethylating Agents

American Journal of Hematology, EarlyView.
ABSTRACT Hypomethylating agents (HMA) and allogeneic hematopoietic stem cell transplantation (alloHSCT) have both demonstrated remissions in VEXAS; however, comparative data is lacking. We conducted a multicenter, retrospective analysis of 66 patients diagnosed with VEXAS syndrome treated with HMA (n = 35) or alloHSCT (n = 31). Baseline characteristics
Saubia Fathima, Margaret Mei‐Kay Wong, Jesus Gonzalez‐Lugo, Susan M. Geyer, Ali Alsugair, Maria Sirenko, Kimberly J. Langer, Terra L. Lasho, Christy Finke, Jun Choi, Maher Abdul‐Hay, Gary Ho, Mark R. Litzow, Aasiya Matin, Urshila Durani, Mehrdad Hefazi, William J. Hogan, Mithun V. Shah, Aref Al‐Kali, Kebede H. Begna, Naseema Gangat, Antoine N. Saliba, Ronald S. Go, Tariq Kewan, Gabriel Bartoo, Jade Kutzke, Kristen McCullough, Kenneth J. Warrington, Megan Sullivan, Kaaren K. Reichard, Horatiu Olteanu, Hemant Murthy, Talha Badar, Yael Kusne, Jeanne Palmer, Saurabh Chhabra, Nathan Punwani, Mary Riwes, Joseph P. McGuirk, Elizabeth F. Krakow, Amelia Langston, Taxiarchis Kourelis, David Dingli, James Foran, Matthew J. Koster, Mrinal M. Patnaik, David B. Beck, Hassan B. Alkhateeb, Abhishek A. Mangaonkar   +48 more
wiley   +1 more source

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Splicing factors: Insights into their regulatory network in alternative splicing in cancer

Cancer Letters, 2021
More than 95% of all human genes are alternatively spliced after transcription, which enriches the diversity of proteins and regulates transcript and/or protein levels. The splicing isoforms produced from the same gene can manifest distinctly, even exerting opposite effects.
Jun-Xian, Du, Gui-Qi, Zhu, Jia-Liang, Cai, Biao, Wang, Yi-Hong, Luo, Cong, Chen, Cheng-Zhe, Cai, Si-Jia, Zhang, Jian, Zhou, Jia, Fan, Wei, Zhu, Zhi, Dai   +11 more
openaire   +2 more sources

[Oncogenic transcription factors as splicing regulators].

Medecine sciences : M/S, 2004
Oncogene activity ranges from transduction signals to transcription factors. Altered expression of oncogenes, either by chromosomal translocation, proviral insertion or point mutations, can lead to tumor formation. More specifically, data accumulated through the last two decades have shown that disregulation of oncogenic transcription factors can ...
Théoleyre, O., Baklouti, F.
openaire   +3 more sources

Splice Factor

Science, 2008
Alternative splicing of transcripts generates significant functional diversity within genomes. This is particularly well illustrated by the CD45 gene, which undergoes regulated activation-dependent alternative splicing in lymphocytes to generate several functionally distinct isoforms. Oberdoerffer et al.
openaire   +2 more sources

Modelling the compartmentalization of splicing factors

Journal of Theoretical Biology, 2006
Splicing factor (SF) compartments, also known as speckles, are heterogeneously distributed compartments within the nucleus of eukaryotic cells that are enriched in pre-mRNA SFs. We derive a fourth-order aggregation-diffusion model that describes a possible mechanism underlying the organization of SFs into speckles. The model incorporates two hypotheses,
Carrero, G., Hendzel, M. J., de Vries, G.   +2 more
openaire   +3 more sources

The Arabidopsis splicing factor SR1 is regulated by alternative splicing

Plant Molecular Biology, 2000
The serine-arginine (SR)-rich splicing factors play essential roles in general splicing and regulate alternative splice site utilization in a concentration-dependent manner. SR1 is a plant homologue of the human general/alternative splicing factor SF2/ASF. We report here that alternative splicing regulates SR1 itself.
G, Lazar, H M, Goodman
openaire   +2 more sources

A PROTAC targets splicing factor 3B1

Cell Chemical Biology, 2021
The proteolysis-targeting chimeras (PROTACs) are a new technology to degrade target proteins. However, their clinical application is limited currently by lack of chemical binders to target proteins. For instance, it is still unknown whether splicing factor 3B subunit 1 (SF3B1) is targetable by PROTACs.
Rodrigo A. Gama-Brambila, Jie Chen, Jun Zhou, Georg Tascher, Christian Münch, Xinlai Cheng   +5 more
openaire   +2 more sources