Results 261 to 270 of about 215,491 (295)

Regulation of Alternative Splicing in Vivo by Overexpression of Antagonistic Splicing Factors

Science, 1994
The opposing effects of SF2/ASF and heterogeneous nuclear ribonucleoprotein (hnRNP) A1 influence alternative splicing in vitro. SF2/ASF or hnRNP A1 complementary DNAs were transiently overexpressed in HeLa cells, and the effect on alternative splicing of several cotransfected reporter genes was measured.
Caceres, JF, Stamm, S, Helfman, DM Helfman, David M, Krainer, AR   +3 more
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Splice factor mutations and alternative splicing as drivers of hematopoietic malignancy

Immunological Reviews, 2014
SummaryDifferential splicing contributes to the vast complexity of mRNA transcripts and protein isoforms that are necessary for cellular homeostasis and response to developmental cues and external signals. The hematopoietic system provides an exquisite example of this.
Hahn, C., Venugopal, P., Scott, H., Hiwase, D.   +3 more
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Splicing factor mutations in AML

Blood, 2014
In this issue of Blood , Taskesen et al propose a novel subset of myeloid neoplasms that encompasses splicing factor (SF) mutation-positive refractory anemia with excess blasts (RAEB) and acute myeloid leukemia (AML), which is composed of 2 molecularly and clinically distinct subgroups ...
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Minimum Factorization Agreement of Spliced ESTs

2009
Producing spliced EST sequences is a fundamental task in the computational problem of reconstructing splice and transcript variants, a crucial step in the alternative splicing investigation. Now, given an EST sequence, there can be several spliced EST sequences associated to it, since the original EST sequences may have different alignments against ...
BONIZZONI, PAOLA, DELLA VEDOVA, GIANLUCA, Dondi, R, PIROLA, YURI, RIZZI, RAFFAELLA   +4 more
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Non-snRNP protein splicing factors

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1993
III. Protein motifs in non-snRNP splicing factors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 250 A. The RRM (RBD-CS) motif . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 250 B. The SR motif . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Lamm, Gábor M., Lamond, Angus I.
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Abstract 1097: Knockdown of splicing factor ESRP1 affects multiple splicing factors

Cancer Research, 2015
Abstract Introduction: Tissue-specific alternative splicing (AS) is an important mechanism for regulating gene expression. Epithelial Splicing Regulatory Proteins 1 and 2 (ESRP1 and ESRP2), two RNA-binding proteins (RBPs) that promote splicing, are potential candidates that contribute to breast cancer recurrence and resistance to ...
Yesim Gökmen-Polar, Yaseswini Neelamraju, Xiaoping Gu, Gouthami Nallamothu, Sarath C. Janga, Sunil Badve   +5 more
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A pan-cancer analysis of alternative splicing of splicing factors in 6904 patients

Oncogene, 2021
Great progress has been made in the investigation on mutation and expression of splicing factor. However, little is known on the role of alternative splicing of splicing factors across cancers. Here, we reported a pan-cancer analysis of alternative splicing of splicing factors spanning 6904 patients across 16 cancer types, and identified 167 splicing ...
Rui Cheng, Lixing Xiao, Wenyang Zhou, Xiyun Jin, Zhaochun Xu, Chang Xu, Pingping Wang, Meng Luo, Mengyun Wang, Kexin Ma, Huimin Cao, Yan Huang, Xiaoyu Lin, Fenglan Pang, Yiqun Li, Qinghua Jiang   +15 more
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Splicing Factor Mutations in Cancer

2016
Many cancers demonstrate aberrant splicing patterns that contribute to their development and progression. Recently, recurrent somatic mutations of genes encoding core subunits of the spliceosome have been identified in several different cancer types.
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Modulation of Splicing Factor Function and Alternative Splicing Outcomes

2022
Alternative RNA splicing is an important means of genetic control and transcriptome diversity. Alternative splicing events are frequently studied independently, and coordinated splicing controlled by common factors is often overlooked: The molecular mechanisms by which splicing regulators promote or repress specific pre-mRNA processing are still not ...
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Adaptive transcription-splicing resynchronization upon losing an essential splicing factor

Nature Ecology & Evolution, 2018
Essential genes form the core of a genome and are therefore thought to be indispensable for cellular viability. However, recent findings have challenged this notion in that cells may survive in the absence of some essential genes provided that relevant genetic modifiers are in existence.
Shang-Lin Chang, Hsuan-Kai Wang, Luh Tung, Tien-Hsien Chang   +3 more
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