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Impact of Splicing Factor Mutations on Pre-mRNA Splicing in the Myelodysplastic Syndromes
Current Pharmaceutical Design, 2016Splicing is an essential cellular process which is carried out by the spliceosome in order to remove the introns and join the exons present in pre-mRNA transcripts. A variety of spliceosomal mutations have been recently identified in the myelodysplastic syndromes (MDS), a heterogeneous group of hematopoietic stem cell malignancies, revealing a new ...
Bon Ham, Yip +4 more
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Alternative pre-mrna splicing: Factors involved in splice site selection
Journal of Cell Science, 1994The protein-coding regions of most vertebrate genes are split, giving rise to primary transcripts containing introns and exons; the latter must be spliced in the nucleus to form the mature mRNA, which then moves to the cytoplasm for translation. Pre-mRNA splicing, the process of intron removal and exon joining, represents an important function within ...
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The physiology of alternative splicing
Nature Reviews Molecular Cell Biology, 2022Luciano E Marasco +2 more
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RNA splicing dysregulation and the hallmarks of cancer
Nature Reviews Cancer, 2023Robert K Bradley +2 more
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Pseudouridylation alters splicing
Nature Reviews Molecular Cell Biology, 2022Eytan Zlotorynski, Zlotorynski Eytan
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Does species-specific alternative splicing make us human?
Nature Reviews Molecular Cell Biology, 2023Heyd Florian
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From trans-splicing discovery and onwards, trypanosomes lead the way
Nature Reviews Molecular Cell Biology, 2022Idálio J Viegas +2 more
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Regulation of pre-mRNA splicing: roles in physiology and disease, and therapeutic prospects
Nature Reviews Genetics, 2022Malgorzata Ewa Rogalska +2 more
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Alternative splicing as a regulator of development and tissue identity
Nature Reviews Molecular Cell Biology, 2017FRANCISCO E Baralle +2 more
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