Results 21 to 30 of about 25,947 (204)

Eimeria tenella protein trafficking: differential regulation of secretion versus surface tethering during the life cycle [PDF]

, 2017
Eimeria spp. are intracellular parasites that have a major impact on poultry. Effective live vaccines are available and the development of reverse genetic technologies has raised the prospect of using Eimeria spp.
Blake, D P, Crouch, C, Long, E, Marugan-Hernandez, V, Tomley, F M   +4 more
core   +1 more source

Effect of the Aedes fluviatilis saliva on the development of Plasmodium gallinaceum infection in Gallus (gallus) domesticus

Memorias do Instituto Oswaldo Cruz, 2004
Effect of Aedes fluviatilis saliva on the development of Plasmodium gallinaceum experimental infection in Gallus (gallus) domesticus was studied in distinct aspects.
Ana CVM da Rocha, Érika M Braga, Márcio SS Araújo, Bernardo S Franklin, Paulo FP Pimenta   +4 more
doaj   +1 more source

Culicoides segnis and Culicoides pictipennis Biting Midges (Diptera, Ceratopogonidae), New Reported Vectors of Haemoproteus Parasites

Microorganisms, 2022
As bloodsuckers of birds, Culicoides biting midges (Diptera, Ceratopogonidae) play an important role in the transmission of avian haemosporidian (Haemoproteus) parasites, which are prevalent in many bird populations and cause disease, pathology, or even ...
Rita Žiegytė, Rasa Bernotienė, Vaidas Palinauskas   +2 more
doaj   +1 more source

Defining stage-specific activity of potent new inhibitors of Cryptosporidium parvum growth in vitro [PDF]

, 2020
Currently, nitazoxanide is the only FDA-approved treatment for cryptosporidiosis; unfortunately, it is ineffective in immunocompromised patients, has varied efficacy in immunocompetent individuals, and is not approved in infants under 1 year of age ...
Funkhouser-Jones, Lisa J, Ravindran, Soumya, Sibley, L. David   +2 more
core   +2 more sources

The mucin-like, secretory type-I transmembrane glycoprotein GP900 in the apicomplexan Cryptosporidium parvum is cleaved in the secretory pathway and likely plays a lubrication role

Parasites & Vectors, 2022
Background Cryptosporidium parvum is a zoonotic parasite and member of the phylum Apicomplexa with unique secretory organelles, including a rhoptry, micronemes and dense granules that discharge their contents during parasite invasion.
Xiaohui Li, Jigang Yin, Dongqiang Wang, Xin Gao, Ying Zhang, Mingbo Wu, Guan Zhu   +6 more
doaj   +1 more source

Plasmodium Sporozoite Biology [PDF]

Cold Spring Harbor Perspectives in Medicine, 2017
Plasmodium sporozoite transmission is a critical population bottleneck in parasite life-cycle progression and, hence, a target for prophylactic drugs and vaccines. The recent progress of a candidate antisporozoite subunit vaccine formulation to licensure highlights the importance of sporozoite transmission intervention in the malaria control portfolio.
Friedrich, Frischknecht, Kai, Matuschewski   +1 more
openaire   +2 more sources

Immunization with CSP and a RIG-I Agonist is Effective in Inducing a Functional and Protective Humoral Response Against Plasmodium

Frontiers in Immunology, 2022
Malaria is a major public health concern, as a highly effective human vaccine remains elusive. The efficacy of a subunit vaccine targeting the most abundant protein of the sporozoite surface, the circumsporozoite protein (CSP) has been hindered by ...
Ana Rafaela Teixeira, Ana Rafaela Teixeira, Ana Rafaela Teixeira, Begoña Pérez-Cabezas, Begoña Pérez-Cabezas, David M. Costa, David M. Costa, Mónica Sá, Mónica Sá, Mónica Sá, Sylvain Golba, Hélèna Sefiane-Djemaoune, Joana Ribeiro, Joana Ribeiro, Izumi Kaneko, Shiroh Iwanaga, Masao Yuda, Moriya Tsuji, Silvia Beatriz Boscardin, Silvia Beatriz Boscardin, Rogerio Amino, Anabela Cordeiro-da-Silva, Anabela Cordeiro-da-Silva, Anabela Cordeiro-da-Silva, Joana Tavares, Joana Tavares, Joana Tavares   +26 more
doaj   +1 more source

Studying the effect of chloroquine on sporozoite-induced protection and immune responses in Plasmodium berghei malaria [PDF]

, 2015
BACKGROUND Sporozoite immunization of animals and humans under a chemo-prophylactic cover of chloroquine (CPS-CQ) efficiently induces sterile protection against malaria.
Bijker, Else M, Cockburn, Ian, Nganou-Makamdop, Krystelle, Sauerwein, Robert W, van Gemert, Geert-Jan, Zavala, Fidel   +5 more
core   +2 more sources

Virosome-formulated Plasmodium falciparum AMA-1 & CSP derived peptides as malaria vaccine: randomized phase 1b trial in semi-immune adults & children. [PDF]

, 2011
BACKGROUND\ud \ud This trial was conducted to evaluate the safety and immunogenicity of two virosome formulated malaria peptidomimetics derived from Plasmodium falciparum AMA-1 and CSP in malaria semi-immune adults and children.\ud \ud METHODS\ud \ud The
Cech, Patrick Georges, Aebi, Thomas, Abdallah, Mwanajaa Shomari, Mpina, Maxmillian, Machunda, Ester Barnabas, Westerfeld, Nicole, Stoffel, Sabine Alexandra, Zurbriggen, Rinaldo, Pluschke, Gerd, Tanner, Marcel, Daubenberger, Claudia, Genton, Blaise, Abdulla, Salim   +12 more
core   +7 more sources

Optimising Controlled Human Malaria Infection Studies Using Cryopreserved P. falciparum Parasites Administered by Needle and Syringe.

PLoS ONE, 2013
BackgroundControlled human malaria infection (CHMI) studies have become a routine tool to evaluate efficacy of candidate anti-malarial drugs and vaccines.
Susanne H Sheehy, Alexandra J Spencer, Alexander D Douglas, B Kim Lee Sim, Rhea J Longley, Nick J Edwards, Ian D Poulton, Domtila Kimani, Andrew R Williams, Nicholas A Anagnostou, Rachel Roberts, Simon Kerridge, Merryn Voysey, Eric R James, Peter F Billingsley, Anusha Gunasekera, Alison M Lawrie, Stephen L Hoffman, Adrian V S Hill   +18 more
doaj   +1 more source