Results 61 to 70 of about 25,947 (204)
ABSTRACT Malaria, a febrile disease caused by the Plasmodium parasites and transmitted by mosquitoes, is a leading cause of mortality in children under 5 in endemic countries. The widespread deployment of insecticide‐treated bed nets (ITNs) has significantly reduced malaria transmission, but rising levels of insecticide resistance threaten to halt the ...
Harun N. Njoroge +21 more
wiley +1 more source
Plasmodium sporozoites induce regulatory macrophages
Professional antigen-presenting cells (APCs), like macrophages (Mϕs) and dendritic cells (DCs), are central players in the induction of natural and vaccine-induced immunity to malaria, yet very little is known about the interaction of SPZ with human APCs.
Béatrice M. F. Winkel +14 more
openaire +5 more sources
Plasmodium berghei sporozoite invasion is blocked in vitro by sporozoite-immobilizing antibodies [PDF]
A monoclonal antibody directed against the circumsporozoite protein on the surface of Plasmodium berghei sporozoites inhibited sporozoite motility in vitro. These immobilized sporozoites could adhere to but not invade target cultured cells. Other sporozoite-immobilizing agents also inhibited sporozoite invasion into cultured cells and did not prevent ...
M J, Stewart +3 more
openaire +2 more sources
Taxonomy of North American fish Eimeriidae [PDF]
Taxonomic descriptions, line drawings, and references are given for the 30 named and 5 unnamed species of North American fish Eimeriidae. In addition, a key was developed based on available morphologic data to distinguish between similar species.
Current, William L. +3 more
core +1 more source
Functional profiles of orphan membrane transporters in the life cycle of the malaria parasite [PDF]
Assigning function to orphan membrane transport proteins and prioritizing candidates for detailed biochemical characterization remain fundamental challenges and are particularly important for medically relevant pathogens, such as malaria parasites.
Kenthirapalan, Sanketha +3 more
core +4 more sources
Clathrins Are Involved in the Endocytosis of Host Cytosol in the Malaria Parasite
This study characterized clathrin function in hemoglobin uptake from host red blood cells via the malaria parasite's specific endocytosis machinery, cytostome. Clathrin heavy chain, clathrin light chain, and AP‐1 γ subunit were found associated with certain proteins known to be involved in cytostome function, and they were localized at the collars of ...
Jun Miao +10 more
wiley +1 more source
The relationship between Plasmodium falciparum gametocyte density and infections in mosquitoes is central to understanding the rates of transmission with important implications for control.
Ashutosh K. Pathak +10 more
doaj +1 more source
In vitro inhibitory activities of sugarcane extract on avian Eimeria sporozoites
The current in vitro study aimed to investigate the effects of a processed sugarcane extract on the viability of avian Eimeria sporozoites. Treatments were applied to hatched sporozoites: 1) without additives (no-treatment control); 2) with ethanol; 3 ...
Ali Daneshmand +9 more
doaj +1 more source
Seasonal and spatial dynamics of the primary vector of plasmodium knowlesi within a major transmission focus in Sabah, Malaysia [PDF]
Background The simian malaria parasite Plasmodium knowlesi is emerging as a public health problem in Southeast Asia, particularly in Malaysian Borneo where it now accounts for the greatest burden of malaria cases and deaths.
Chua, Tock H. +9 more
core +4 more sources
Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen +30 more
wiley +1 more source

