Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization,secondary mediators, and Rac [PDF]
, 2010 The C-type lectin-like receptor 2 (CLEC-2)activates platelets through Src and Syk tyrosine kinases via a single cytoplasmic YxxL motif known as a hem immunoreceptor tyrosine-based activation motif (hemITAM).Here, we demonstrate using sucrose gradient ...
Alice Y. Pollitt +44 more
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Targeting Btk/Etk of prostate cancer cells by a novel dual inhibitor. [PDF]
, 2014 Btk and Etk/BMX are Tec-family non-receptor tyrosine kinases. Btk has previously been reported to be expressed primarily in B cells and has an important role in immune responses and B-cell malignancies.
Bhardwaj, G +16 more
core +2 more sources
Endocytosis and the Src family of non-receptor tyrosine kinases
Biomolecular Concepts, 2014 The regulated intracellular transport of nutrient, adhesion, and growth factor receptors is crucial for maintaining cell and tissue homeostasis. Endocytosis, or endocytic membrane trafficking, involves the steps of intracellular transport that include ...
Reinecke James, Caplan Steve
doaj +1 more source
SRC kinase-mediated signaling pathways and targeted therapies in breast cancer
Breast Cancer Research, 2022 Breast cancer (BC) has been ranked the most common malignant tumor throughout the world and is also a leading cause of cancer-related deaths among women. SRC family kinases (SFKs) belong to the non-receptor tyrosine kinase (nRTK) family, which has eleven
Juan Luo +9 more
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GRID and docking analyses reveal a molecular basis for flavonoid inhibition of src-family kinase activity [PDF]
, 2015 Flavonoids reduce cardiovascular disease risk through anti-inflammatory, anti-coagulant and anti-platelet actions. One key flavonoid inhibitory mechanism is blocking kinase activity that drives these processes.
Gibbins, Jon M. +4 more
core +1 more source
Development of the Sensing Platform for Protein Tyrosine Kinase Activity
Biosensors, 2021 A miniature tyrosinase-based electrochemical sensing platform for label-free detection of protein tyrosine kinase activity was developed in this study. The developed miniature sensing platform can detect the substrate peptides for tyrosine kinases, such ...
Lan-Yi Wei +5 more
doaj +1 more source
Efficient and Accurate Modeling of Conformational Transitions in Proteins: The Case of c-Src Kinase [PDF]
, 2018 The theoretical computational modeling of large conformational transitions occurring in biomolecules still represents a challenge. Here, we present an accurate "in silico" description of the activation and deactivation mechanisms of human c-Src kinases ...
Alexandra G. Trandafir +4 more
core +2 more sources
A novel anti-melanoma SRC-family kinase inhibitor [PDF]
Oncotarget, 2019 The major drawback of melanoma therapy with BRAF and MAPK inhibitors is the innate and acquired drug resistance. We therefore explored alternative targets and developed a new compound, SAB298, that is a SRC-family kinase (SFK) inhibitor. The drug is cytotoxic to patient-derived melanoma cells regardless of oncogene expression and inhibits tumor growth ...
Halaban, Ruth +8 more
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Fcgamma receptor-mediated phagocytosis in macrophages lacking the Src family tyrosine kinases Hck, Fgr, and Lyn. [PDF]
, 2000 Macrophage Fcgamma receptors (FcgammaRs) mediate the uptake and destruction of antibody-coated viruses, bacteria, and parasites. We examined FcgammaR signaling and phagocytic function in bone marrow-derived macrophages from mutant mice lacking the major ...
Crowley, MT +6 more
core
Src family kinases, key regulators of signal transduction [PDF]
Oncogene, 2004 The Src family of protein tyrosine kinases (SFKs) plays key roles in regulating signal transduction by a diverse set of cell surface receptors in the context of a variety of cellular environments. SFKs have evolved many ingenious molecular strategies to couple receptors with the cytoplasmic signaling machinery.
Sarah J, Parsons, J Thomas, Parsons
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