Results 191 to 200 of about 150,059 (222)

The Drug Safety Framework of Avacopan: A Pharmacovigilance Study

Medicine Advances, EarlyView.
We identified 11 previously unreported potential adverse events associated with avacopan. No high‐priority clinical events were observed; however, special attention should be paid to the potential possibility of avacopan‐induced vanishing bile duct syndrome (Logos and icons displayed in the sections “Safety Framework” and “Data Sources and ...
Tianqi Chang, Xiaohong Xin, Xian Shao, Dikang Pan, Jingyu Wang   +4 more
wiley   +1 more source

Wasting syndrome as a predictive factor for adverse health outcomes in older adults: A prospective cohort study

Nutrition in Clinical Practice, EarlyView.
Abstract Wasting syndrome (WS), also known as unintentional weight loss, is defined as a 5% reduction in body weight over a period of 6–12 months. The mortality associated with WS in older adults has not been adequately explored. The objective of this study was to investigate this relationship in hospitalized older individuals over an 18‐month period ...
Roana Carolina Bezerra dos Santos, Cláudia Porto Sabino Pinho, Eduila Maria Couto Santos, Maria Caroline da Silva Patricio, Stefany Beatriz do Nascimento, Letícia Sabino Santos, Taynara de Sousa Rego Mendes, Alcides da Silva Diniz   +7 more
wiley   +1 more source

Osmolality of fortified human milk with contemporary human milk fortifiers

Nutrition in Clinical Practice, EarlyView.
Abstract Background Human milk fortification is critical to support preterm infant growth. Human milk fortifed to caloric densities above manufacturers’ recommendations are often necessary to achieve adequate growth. Fortified milk may be prepared 12–24 h before feeding, although practice variations exist.
Abigail Gardiner, Irmalís Flores González, Carrie Smith, Jacqueline Wessel, Jae H. Kim, Ting Ting Fu   +5 more
wiley   +1 more source

Taxonomic insights into Indian Rotala (Lythraceae) species with verticillate phyllotaxy

Nordic Journal of Botany, EarlyView.
In an effort to resolve taxonomic complexities among Indian Rotala species with verticillate phyllotaxy, this study provides an identification key, revised nomenclature, updated morphological descriptions including SEM studies of seed coat surfaces, detailed photoplates, and notes on phenology, ecology, and distribution.
Arikrishnan Parthiban, Ladan Rasingam, Sandhya Deepika Devara   +2 more
wiley   +1 more source

Association of Glucagon‐Like Peptide‐1 Receptor Agonists With Cancer Risk in Older Adults With Type 2 Diabetes

Obesity, EarlyView.
ABSTRACT Objective The real‐world evidence on the association between glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) and cancer risk remains limited and mixed. Methods In 2013–2020 national Medicare claims data, we included cancer‐naïve patients with type 2 diabetes (T2D). We identified those who initiated GLP‐1 RA, sodium‐glucose cotransporter 2
Ying Lu, Hao Dai, Huilin Tang, William T. Donahoo, Thomas J. George, Ramon C. Sun, Sizun Jiang, Aik Choon Tan, Yi Guo, Jonathan D. Licht, John M. Allen, Kelvin P. Lee, Jingchuan Guo, Jiang Bian   +13 more
wiley   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

Synthesis of Pyrido[2,3‐d]Azolopyrimidinones: Design and Epidermal Growth Factor Receptor‐Targeted Molecular Docking Toward Novel Anticancer Leads

ChemistryOpen, EarlyView.
New pyrido[2,3‐d]azolopyrimidinones were synthesized and evaluated as potent EGFR‐targeted anticancer leads. Molecular docking and cytotoxicity studies revealed strong receptor binding and submicromolar activity, highlighting this scaffold as a promising framework for future targeted drug development.
Sobhi M. Gomha, Sami A. Al‐Hussain, Basant Farag, AbdElAziz A. Nayl, Wesam Hussein, Abdelwahed R. Sayed, Magdi E. A. Zaki   +6 more
wiley   +1 more source

FTH1‐Related Neuroferritinopathy: A Rare Form of Neurodegeneration with Brain Iron Accumulation Mimicking Pontocerebellar Hypoplasia

Movement Disorders Clinical Practice, EarlyView.
Sayoni Roy Chowdhury, Sangeetha Yoganathan, Vivek Pai, Andrea LeBlanc‐Millar, Vann Chau, Roberto Mendoza‐Londono, Lucie Dupuis, Carolina Gorodetsky   +7 more
wiley   +1 more source

The Src inhibitor peptide TAT-Cx43_266-283 improves survival in an intracranial murine model of lung cancer brain metastasis. [PDF]

Neurooncol Adv
Cerveró-García P, Jiménez-Madrona E, Álvarez-Vázquez A, Flores-Hernández R, García-Vicente L, García-Guerrero L, Alonso-Amador JJ, González-Sánchez R, Ollauri-Ibáñez C, Paniagua-Sancho M, Talaverón R, Rodrigues-Teixeira T, Martín-Guerrero SM, Casado P, Rajeeve V, Shields T, Hijazi M, Cutillas PR, Jaraíz-Rodríguez M, Tabernero A.   +19 more
europepmc   +1 more source

Protein-protein interaction-interfering peptide rescues dysregulated NMDA receptor signaling. [PDF]

JCI Insight
Featherstone RE, Li H, Sengar AS, Borgmann-Winter KE, Melnychenko O, Crown LM, Gifford RL, Amirfathi F, Banerjee A, Tran A, Parekh K, Heller M, Zhang W, Gallop RJ, Marc AD, Komal P, Salter MW, Siegel SJ, Hahn CG.   +18 more
europepmc   +1 more source