Results 201 to 210 of about 44,786 (250)

Rapid sequence evolution of the mammalian sex-determining gene SRY

Trends in Genetics, 1993
In mammals, induction of male sex determination requires the Y-chromosome gene SRY. SRY encodes a protein with a central 'high mobility group' domain (HMG box) of about 78 amino acids. HMG boxes are found in a wide variety of proteins that bind to DNA with high affinity but differing degrees of sequence specificity.
L S, Whitfield, R, Lovell-Badge, P N, Goodfellow   +2 more
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SRY-related genes in Xenopus oocytes

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1996
SRY-related genes are known as Sox (Sry-box) genes. Two Sox cDNAs from Xenopus oocytes were analyzed. The deduced product of the Xenopus Sox gene (xSox-11) consisted of the standard domains of an HMG box, glycine/alanine-rich region and glutamic acid/aspartic acid-rich region and may be involved in the control of transcription. The other Sox gene (xSox-
S, Miyata, K, Miyashita, Y, Hosoyama
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SRY – o gene da determinação sexual

Genética na Escola, 2023
O processo de determinação sexual em humanos começa muito antes do nascimento; é na concepção que o sexo cromossômico é determinado: XX ou XY. No cromossomo Y está presente o fator de determinação sexual: o gene SRY. Este gene de apenas um éxon desencadeia uma cascata de processos que envolve muitos outros genes e sua expressão pode ser detectada ainda
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A novel Xenopus laevis SRY-related gene, xSox33

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2003
The sex-determining region Y (SRY) gene and its related Sox genes encode transcriptional regulatory factors. In this study, we isolated and sequenced a novel Sox cDNA from African clawed frog (Xenopus laevis). The Sox gene was named xSox33. xSox33 was revealed to encode 244 amino acids.
Jun, Hagiuda, Yoshiki, Hiraoka, Masanori, Hasegawa, Motoyuki, Ogawa, Sadakazu, Aiso   +4 more
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Regulation of tyrosine hydroxylase gene transcription by Sry

Neuroscience Letters, 2004
Testes determining factor Sry is encoded by the Sry locus on the Y chromosome and may be involved in the regulation of blood pressure. Here we tested the hypothesis that Sry regulates transcription of tyrosine hydroxylase (TH), the rate-limiting enzyme in the biosynthesis of catecholamines. Sry was found to be expressed in catecholaminergic regions, in
Amy, Milsted, Lidia, Serova, Esther L, Sabban, Gail, Dunphy, Monte E, Turner, Daniel L, Ely   +5 more
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Sequence evolution of SRY gene within Bovidae family

Mammalian Genome, 1994
In mammals, male sex determination requires a dominant factor provided by the Y Chromosome (Chr). The SRY gene corresponds to this key factor (Sinclair et al. 1990) and is conserved in mammalian species (Foster et al. 1992). The predicted amino acid sequence of SRY contains a central "high mobility group" domain (HMG-box) characteristic of a wide ...
Payen, E.J., Cotinot, C.Y.
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Candidate genes in complete and partial XY sex reversal: Mutation analysis of SRY, SRY-related genes and FTZ-F1

Molecular and Cellular Endocrinology, 1998
The sexual phenotype is established in three steps: (1) the sex chromosome constitution; (2) the differentiation of the gonads; and (3) the response of the internal and external genitalia to the hormones produced by the differentiated gonads. Errors that occur at any of these stages can result in defective sexual differentiation.
H N, Lim, S H, Freestone, D, Romero, C, Kwok, I A, Hughes, J R, Hawkins   +5 more
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The SRY gene

Trends in Endocrinology & Metabolism, 1993
SRY was identified in an attempt to clone the mammalian testisdetermining factor. Evidence in the form of sex-reversing mutations and mouse transgenesis experiments indicates that SRY is the testis-determining factor. The cloning of this gene marks the end of the beginning of our understanding of sex determination.
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Characterization of an SRY-like gene, DSox14 , from Drosophila

Gene, 2001
We have characterized the DSox14 gene, a new member of the family of transcription factors related to the mammalian sex determining factor, SRY. It contains two exons and the intron is large for Drosophila at 2.8 kb. The encoded protein consists of 691 amino acids (72 kDa) and includes an HMG box domain, which is closely related to the mouse Sox4 DNA ...
A C, Sparkes, K L, Mumford, U A, Patel, S F, Newbury, C, Crane-Robinson   +4 more
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Studies on the phylogenetic conservation of the SRY gene

Human Genetics, 1991
A probe from a conserved motif of the SRY gene (sex-determining region Y), a prime candidate for the human testis-determinant, was hybridized to DNA from 23 species representing 5 vertebrate classes. Hybridization occurred in species with male or female heterogamety, in species with and without sex chromosomes and in those with temperature sex ...
T R, Tiersch, M J, Mitchell, S S, Wachtel   +2 more
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