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Molecular evolution of Sry and Sox gene
Gene, 2000The mammalian Sry on the short arm of the Y chromosome encodes a nuclear factor-like protein harboring a DNA-binding domain known as the HMG box. The Sox genes encode similar factor like proteins, but the sequence similarity of the HMG box to that of Sry is variable as being at least 60%.
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XLS13A and XLS13B: SRY-related genes of Xenopus laevis
Gene, 1997SRY-related cDNAs, XLS13A and XLS13B, have been isolated from Xenopus laevis ovary. The cDNAs encode polypeptides of 382 and 375 amino acids, respectively. Nucleotide sequences of the two cDNAs are highly homologous to each other. The type-A and type-B XLS13 proteins, and xSox13 reported previously share an identical high mobility group (HMG) box at ...
Y, Hiraoka +5 more
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Expression of Sry, the mouse sex determining gene
Development, 1995ABSTRACT In the mouse, Sry is expressed by germ cells in the adult testis and by somatic cells in the genital ridge. Transcripts in the former exist as circular RNA molecules of 1.23 kb, which are unlikely to be efficiently translated. We have used RNase protection to map the extent of the less abundant Sry transcript in the developing ...
A, Hacker +3 more
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Sry and Sox9: mammalian testis-determining genes
Cellular and Molecular Life Sciences, 1999Sry is the Y-chromosomal gene that acts as a trigger for male development in mammalian embryos. This gene encodes a high mobility group (HMG) box transcription factor that is known to bind to specific target sequences in DNA and to cause a bend in the chromatin.
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Stage‐specific regulatory element of mouse Sry gene
Molecular Reproduction and Development, 2003AbstractSry expression is essential for initiating male sex differentiation, and the expression occurs only during a restricted period in the developing gonad. It is thought that Sry is part of a pathway of genes that regulate sex determination. Although the interactions of several genes with Sry expression have been suggested, the exact cascade of ...
Kou, Yokouchi +9 more
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Nucleotide composition and codon usage bias of SRY gene
Andrologia, 2017The SRY gene is present within the sex-determining region of the Y chromosome which is responsible for maleness in mammals. The nonuniform usage of synonymous codons in the mRNA transcript for encoding a particular amino acid is the codon usage bias (CUB). Analysis of codon usage pattern is important to understand the genetic and molecular organisation
M N, Choudhury, A, Uddin, S, Chakraborty
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Analysis of SRY Gene in 8 Cases of Sex Abnormality
Current Medical Science, 2004In order to investigate the relationship between sex dysplasia and sex-determining region Y (SRY) gene, 8 patients with sexual abnormality were analyzed by cytogenetic and molecular genetic methods. Fluorescence in situ hybridization (FISH) using PY3.4, X alpha satellite, and SRY probes was performed in each case to analyze the sex chromosome ...
Hui, Wang +5 more
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Development in a 46 XX Boy with Positive SRY Gene
Journal of Pediatric Endocrinology and Metabolism, 1996We present the case of an 11 year-old boy, who asked for medical attention due to obesity and assumed underdeveloped external genitalia. He did not have genital anomalies, penile length was 5.3 cm, testicular volume 2 ml and pubic hair Tanner stage 1. His bone age was normal for chronological age.
A, Rego +4 more
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[The human SRY gene for prenatal diagnosis].
Zhonghua fu chan ke za zhi, 1998To establish the method for prenatal sex diagnosis of the fetus carrying sex-linked genetic disorder.Human SRY gene was amplified by polymerase chain reaction. A 422-bp male specific fragment was obtained.The fragment was identified in 10 men, but unidentified in 10 women.
Y, Gao, M, Ma, L, Min
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Detection of the SRY gene in patients with Turner Syndrome
Journal of Gynecology Obstetrics and Human Reproduction, 2019If turner syndrome (TS) patients have a Y-containing cell line, they have an increased risk for gonadal tumors. TS patients are therefore screened for Y-chromosome and Y-specific sequences, such as SRY, DYZ1, DYZ3, DYS132, ZFY, TSPY, etc. In addition, since the dysgenetic gonad may include the stroma and granulosa/sertoli cells, which produce androgens,
Erdal, Kurnaz +3 more
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