Results 141 to 150 of about 1,774 (156)
Impact of the ST101 clone on fatality among patients with colistin-resistant Klebsiella pneumoniae infection [PDF]
Journal of Antimicrobial Chemotherapy, 2018 We describe the molecular characteristics of colistin resistance and its impact on patient mortality.A prospective cohort study was performed in seven different Turkish hospitals. The genotype of each isolate was determined by MLST and repetitive extragenic palindromic PCR (rep-PCR). Alterations in mgrB were detected by sequencing.
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Journal of Alzheimer's Disease, 2015
Abstract Background and Objective: ST101, an acetylcholine release agent with efficacy in rodent memory and cognition models, was assessed for clinical safety and efficacy. Methods: A phase 2 double blind, placebo-controlled study enrolled 210 AD patients (MMSE 10–20) on 10 mg donepezil QD.
Serge Gauthier, Gauthier Serge
exaly +3 more sources
Abstract Background and Objective: ST101, an acetylcholine release agent with efficacy in rodent memory and cognition models, was assessed for clinical safety and efficacy. Methods: A phase 2 double blind, placebo-controlled study enrolled 210 AD patients (MMSE 10–20) on 10 mg donepezil QD.
Serge Gauthier, Gauthier Serge
exaly +3 more sources
Neuro-Oncology, 2023
Abstract BACKGROUND The vast amounts of genomics, epigenomics and transcriptomics data in glioblastoma (GBM) have yet to translate into better outcomes to most patients. One of the main challenges is to how to best integrate these diverse layers of omics to personalize and improve the treatment of ...
F Iwamoto +11 more
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Abstract BACKGROUND The vast amounts of genomics, epigenomics and transcriptomics data in glioblastoma (GBM) have yet to translate into better outcomes to most patients. One of the main challenges is to how to best integrate these diverse layers of omics to personalize and improve the treatment of ...
F Iwamoto +11 more
openaire +1 more source
Cancer Research, 2023
Abstract CCAAT/Enhancer Binding Protein β (C/EBPβ) is a basic leucine zipper (bZIP) transcription factor that causes aberrant gene expression in many cancers. Upregulated or overactivated C/EBPβ drives oncogenesis by promoting tumor survival and proliferation and is a critical regulator of the immunosuppressive tumor microenvironment ...
Claudio Scuoppo +11 more
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Abstract CCAAT/Enhancer Binding Protein β (C/EBPβ) is a basic leucine zipper (bZIP) transcription factor that causes aberrant gene expression in many cancers. Upregulated or overactivated C/EBPβ drives oncogenesis by promoting tumor survival and proliferation and is a critical regulator of the immunosuppressive tumor microenvironment ...
Claudio Scuoppo +11 more
openaire +1 more source
Cancer Research
Abstract CCAAT/Enhancer Binding Protein β (C/EBPβ) is a transcription factor that is an established driver of cellular transformation in several cancer types with poor prognosis, including glioblastoma (GBM), triple negative breast cancer (TNBC) and non-small cell lung cancer (NSCLC).
Claudio Scuoppo +13 more
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Abstract CCAAT/Enhancer Binding Protein β (C/EBPβ) is a transcription factor that is an established driver of cellular transformation in several cancer types with poor prognosis, including glioblastoma (GBM), triple negative breast cancer (TNBC) and non-small cell lung cancer (NSCLC).
Claudio Scuoppo +13 more
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Journal of Clinical Oncology
2016 Background: C/EBPβ is a master regulator of the mesenchymal phenotype in GBM and has an essential role in the maintenance of immunosuppressive M2 tumor-associated macrophages (TAMs). Lucicebtide is a first-in-class antagonist of C/EBPβ that has shown direct anti-tumor activity in GBM as ...
Fabio Massaiti Iwamoto +7 more
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2016 Background: C/EBPβ is a master regulator of the mesenchymal phenotype in GBM and has an essential role in the maintenance of immunosuppressive M2 tumor-associated macrophages (TAMs). Lucicebtide is a first-in-class antagonist of C/EBPβ that has shown direct anti-tumor activity in GBM as ...
Fabio Massaiti Iwamoto +7 more
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ST101 Mechanisms for HIV envelope-induced CD4 T cell death
JAIDS Journal of Acquired Immune Deficiency Syndromes, 2013Haishan Li, C. David Pauza
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