Results 111 to 120 of about 87,432 (237)

The anti‐fibrotic effects of novel heart failure pharmacotherapies in advanced heart failure patients

British Journal of Pharmacology, EarlyView.
Background and Purpose Novel heart failure (HF) pharmacotherapies, including angiotensin receptor‐neprilysin inhibitor (ARNI) and sodium‐glucose cotransporter 2 inhibitors (SGLT2is), may confer cardiovascular benefits by attenuating myocardial fibrosis. However, direct evidence from human failing myocardial samples is limited.
Dávid Nagy, Tamás Radovits, Tímea Bálint, Zoltán Horváth, Petra Kocsis‐Balogh, Ákos Gergely Tóth, Attila Oláh, Alex Ali Sayour, Bálint András Barta, Béla Merkely, Mihály Ruppert   +10 more
wiley   +1 more source

Editorial Perspective: A call for action on imposter participants in child and adolescent mental health research

Child and Adolescent Mental Health, EarlyView.
Imposter participants are dishonest participants who fake their identities or exaggerate their experiences to participate in research. This appears to be a rising problem in quantitative and qualitative research as well as lived experience groups for child and adolescent mental health research.
Brian C.F. Ching, Cornelius Ani, Angie Pitt, Sharon Eager, Emily Simonoff, Johnny Downs   +5 more
wiley   +1 more source

Technology matters: AI‐driven tools in children's mental healthcare: perspectives from young people and parents

Child and Adolescent Mental Health, EarlyView.
Artificial intelligence may be able to improve the efficiency, accuracy and predictiveness of mental health assessments, and public perspectives are crucial to ensuring these tools are implemented with fairness and accountability. We developed an artificial intelligence‐driven tool to automatically analyse parents' speech data, which if successful ...
Zoë Firth, Christine Aicardi, Stephen Oram, Nicholas Cummins, Alice Wickersham, Helen L. Fisher, Johnny Downs   +6 more
wiley   +1 more source

The ST2+ Treg/amphiregulin axis protects from immune-mediated hepatitis

Frontiers in Immunology
IntroductionThe alarmin IL-33 has been implicated in the pathology of immune-mediated liver diseases. IL-33 activates regulatory T cells (Tregs) and type 2 innate lymphoid cells (ILC2s) expressing the IL-33 receptor ST2.
Selina Wachtendorf, Selina Wachtendorf, Fitriasari Jonin, Fitriasari Jonin, Aaron Ochel, Fabian Heinrich, Astrid M. Westendorf, Gisa Tiegs, Gisa Tiegs, Katrin Neumann, Katrin Neumann   +10 more
doaj   +1 more source

Oral Health and Social Isolation After 6 Years: Mediation of Oral Functions

Community Dentistry and Oral Epidemiology, EarlyView.
ABSTRACT Objectives Tooth loss was longitudinally associated with social isolation. The absence of dental prosthesis use was an additional risk factor. However, the mediating pathways for this association are unknown. The aim of this cohort study was to estimate the mediating effect of three oral functions: speaking, smiling and chewing observed at ...
Hazem Abbas, Kenji Takeuchi, Taro Kusama, Sakura Kiuchi, Ken Osaka   +4 more
wiley   +1 more source

Fetal Fraction Signatures: A Quality Control Tool to Detect Potentially Confounding Situations in NonInvasive Prenatal Diagnosis of Monogenic Conditions

Clinical Genetics, EarlyView.
Noninvasive prenatal diagnosis for monogenic diseases (NIPD‐M) to detect inherited mutations is performed in parallel with fetal fraction signatures, to detect various anomalies that may compromise diagnosis. An extra regression analysis may be necessary to resolve mosaic situations. ABSTRACT Noninvasive prenatal diagnosis relies on the analysis of the
Jean‐Louis Blouin, Claudine Rieubland, Thierry Nouspikel   +2 more
wiley   +1 more source

Families' and therapists' experience of a telehealth programme for children and adolescents with cerebral palsy during the COVID‐19 pandemic

Developmental Medicine &Child Neurology, EarlyView.
Experiences of a individualized telehealth home programme. Abstract Aim To understand how families and therapists perceived their participation in an individualized home telehealth programme implemented for children and adolescents with cerebral palsy (CP) during the COVID‐19 pandemic in Brazil.
Rachel Oliveira, Marisa Mancini, Priscilla Figueiredo, Katia Bueno, Andrew M. Gordon, Marina Brandão   +5 more
wiley   +1 more source

Selective Targeting of IL‐1RAP‐Dependent Eosinophilic Inflammation in Allergic Fungal Airway Disease

Allergy, EarlyView.
Thomas J. Williams, James S. Griffiths, Luis E. Gonzales‐Huerta, David Bell, Anna K. Reed, Anand Shah, Julian R. Naglik, Darius Armstrong‐James   +7 more
wiley   +1 more source

The Children's Eating and Drinking Activity Scale: Interrater reliability, concurrent validity, and responsiveness

Developmental Medicine &Child Neurology, EarlyView.
This paper evaluated the interrater reliability, concurrent validity and responsiveness of the Children's Eating and Drinking Activity Scale ‐ a measure of functional outcome for children with paediatric feeding disorder. Abstract Aim To assess the interrater reliability, concurrent validity, and responsiveness of the Children's Eating and Drinking ...
Ericka Joinelle Mantaring, Sheung Yu Sylfiana Wong, Michelle McInerney, Vicky Thorpe, Alexandra Stewart   +4 more
wiley   +1 more source

IL-33/ST2 axis in diverse diseases: regulatory mechanisms and therapeutic potential

Frontiers in Immunology
Interleukin-33 (IL-33) is a nuclear factor and member of the IL-1 cytokine family. IL-33 is mainly expressed by epithelial and endothelial cells and exerts its function through interaction with various immune cells, and binding to its receptor can form ...
Feiya Sheng, Mi Li, Jia-Mei Yu, Si-Yu Yang, Liang Zou, Guan-Jun Yang, Le-Le Zhang, Le-Le Zhang   +7 more
doaj   +1 more source