Results 141 to 150 of about 87,588 (241)
Mixed Signals: T Cells as Architects of IgE Immunity
Immunological Reviews, Volume 339, Issue 1, May 2026.ABSTRACT Food allergen‐specific IgE can cause significant pathology, yet the pathways that generate pathogenic, high‐affinity IgE remain incompletely understood. Increasing evidence suggests that IgE responses arise from the integration of multiple, and sometimes opposing, T cell–derived cues.
Abigail L. Tierney +3 more
wiley +1 more source
Lipid‐Facilitated Opening of the ADAM10 Sheddase Revealed by Enhanced Sampling Simulations
Advanced Science, Volume 13, Issue 19, 2 April 2026.Phosphatidylserine acts as a lipid trigger to enhance activation of the sheddase ADAM10. By integrating fluorescence spectroscopy assays with enhanced sampling molecular dynamics simulations, this study shows that phosphatidylserine promotes ADAM10 catalytic activity along with expansion of its extracellular domains, enhancing accessibility to scaffold
Adrien Schahl +7 more
wiley +1 more source
2026 Update on the Management of Diffuse Large B‐Cell Lymphoma
American Journal of Hematology, Volume 101, Issue 4, Page 832-863, April 2026.ABSTRACT Diffuse large B‐cell lymphoma (DLBCL) is the most common type of NHL in the Western Hemisphere. It comprises a heterogenous group of lymphomas, with different biology and clinical prognoses. R‐CHP remains the backbone of therapy, and frontline therapeutic options in fit patients are pola‐R‐CHP and R‐CHOP, whereas elderly or frail/unfit ...
Elise A. Chong +2 more
wiley +1 more source
Biomedical Chromatography, Volume 40, Issue 4, April 2026.ABSTRACT Violae tianshanicae herba (VTH), a widely used crude drug in Uyghur medicine in China, is renowned for its immunomodulatory, anti‐inflammatory, antibacterial, antiviral, and antidiabetic activities, with notable efficacy in treating asthma. However, systematic research on its quality markers (Q‐markers) remains limited, underscoring the need ...
Haifeng Liu +6 more
wiley +1 more source
Brain Age Estimation on T2‐FLAIR Scans for Application to Multiple Sclerosis
Human Brain Mapping, Volume 47, Issue 5, 1 April 2026.While the brain‐age paradigm has emerged as a promising biomarker of neurodegeneration in multiple sclerosis (MS), most available brain‐age prediction models are based on 3D‐T1w scans, which are not acquired in routine clinical practice. Leveraging a large multicentre collection of scans from healthy controls, we developed an accurate brain‐age ...
Jordan Colman +46 more
wiley +1 more source
MicrobiologyOpen, Volume 15, Issue 2, April 2026.The genomes of coagulase‐negative staphylococci (CoNS) isolated during sequential ear and eye infections in a healthy adult are analyzed. We highlight the identification of a community‐acquired S. capitis subsp. urealyticus ST1 lineage carrying a mosaic SCCmec IV element, linking common skin commensals to multidrug‐resistant strains associated with ...
Soo Sum Lean +6 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 7, Page 1502-1516, April 2026.Background and Purpose Novel heart failure (HF) pharmacotherapies, including angiotensin receptor‐neprilysin inhibitor (ARNI) and sodium‐glucose cotransporter 2 inhibitors (SGLT2is), may confer cardiovascular benefits by attenuating myocardial fibrosis. However, direct evidence from human failing myocardial samples is limited.
Dávid Nagy +10 more
wiley +1 more source
Structures of clinical antibodies bound to IL-33 uncover two distinct epitopes underlying differential efficacy. [PDF]
MAbsChen J, Wang Y, Wang X.
europepmc +1 more source
Oral Health and Social Isolation After 6 Years: Mediation of Oral Functions
Community Dentistry and Oral Epidemiology, Volume 54, Issue 2, Page 220-230, April 2026.ABSTRACT Objectives Tooth loss was longitudinally associated with social isolation. The absence of dental prosthesis use was an additional risk factor. However, the mediating pathways for this association are unknown. The aim of this cohort study was to estimate the mediating effect of three oral functions: speaking, smiling and chewing observed at ...
Hazem Abbas +4 more
wiley +1 more source