Results 51 to 60 of about 218 (97)

Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: New insights. [PDF]

World J Gastroenterol, 2017
To provide new insights in treatment of colitis and ischemia and reperfusion in rats using stable gastric pentadecapeptide BPC 157.Medication [BPC 157, L-NAME, L-arginine (alone/combined), saline] was bath at the blood deprived colon segment. During reperfusion, medication was BPC 157 or saline.
Duzel A, Vlainic J, Antunovic M, Malekinusic D, Vrdoljak B, Samara M, Gojkovic S, Krezic I, Vidovic T, Bilic Z, Knezevic M, Sever M, Lojo N, Kokot A, Kolovrat M, Drmic D, Vukojevic J, Kralj T, Kasnik K, Siroglavic M, Seiwerth S, Sikiric P.   +21 more
europepmc   +5 more sources

Prolonged Esophagitis After Primary Dysfunction of the Pyloric Sphincter in the Rat and Therapeutic Potential of the Gastric Pentadecapeptide BPC 157

Journal of Pharmacological Sciences, 2007
Seven or fourteen days or twelve months after suturing one tube into the pyloric sphincter (removed by peristalsis by the seventh day), rats exhibit prolonged esophagitis with a constantly lowered pressure not only in the pyloric, but also in the lower ...
Ivan Dobric, Petar Drvis, Igor Petrovic, Drazen Shejbal, Luka Brcic, Alenka Boban Blagaic, Lovorka Batelja, Marko Sever, Neven Kokic, Ante Tonkic, Ivan Zoricic, Sandro Mise, Mario Staresinic, Bozo Radic, Ana Jakir, Jaksa Babel, Spomenko Ilic, Tihomir Vuksic, Ivan Jelic, Tomislav Anic, Sven Seiwerth, Predrag Sikiric   +21 more
doaj   +1 more source

Over-Dose Lithium Toxicity as an Occlusive-like Syndrome in Rats and Gastric Pentadecapeptide BPC 157

Biomedicines, 2021
Due to endothelial impairment, high-dose lithium may produce an occlusive-like syndrome, comparable to permanent occlusion of major vessel-induced syndromes in rats; intracranial, portal, and caval hypertension, and aortal hypotension; multi-organ ...
Sanja Strbe, Slaven Gojkovic, Ivan Krezic, Helena Zizek, Hrvoje Vranes, Ivan Barisic, Dean Strinic, Tatjana Orct, Jaksa Vukojevic, Spomenko Ilic, Eva Lovric, Darija Muzinic, Danijela Kolenc, Igor Filipčić, Zoran Zoricic, Darko Marcinko, Alenka Boban Blagaic, Anita Skrtic, Sven Seiwerth, Predrag Sikiric   +19 more
doaj   +1 more source

An Experimental Model of Prolonged Esophagitis With Sphincter Failure in the Rat and the Therapeutic Potential of Gastric Pentadecapeptide BPC 157

Journal of Pharmacological Sciences, 2006
We report a simple novel rat model that combines prolonged esophagitis and parallel sphincters failure. The anti-ulcer gastric pentadecapeptide BPC 157, which was found to be stable in gastric juice, and is being evaluated in inflammatory bowel disease ...
Igor Petrovic, Ivan Dobric, Petar Drvis, Drazen Shejbal, Luka Brcic, Alenka Boban Blagaic, Lovorka Batelja, Neven Kokic, Ante Tonkic, Stjepan Mise, Tomislav Baotic, Mario Staresinic, Bozo Radic, Ana Jakir, Tihomir Vuksic, Tomislav Anic, Sven Seiwerth, Predrag Sikiric   +17 more
doaj   +1 more source

Stable gastric pentadecapeptide BPC 157 and insulin induced gastric lesions in rats.

Journal of physiology and pharmacology, 2009
The stable gastric pentadecapeptid BPC 157 (GEPPGKPADDAGLV, M.W. 1419) is a small anti- ulcer peptide efficient in inflammatory bowed disease trials (PL 14736) and various wound tretment, no toxiicity reported. Interestingly, it may have therapeutic effect on acute panckeatitis and act protzectively on endothelium, affects many central disturbances and
Ilić, S, Mester, M, Filipović, M, Sever, M, Klicek, R, Barisic, I, Zoričić, Z, Bilić, V, Berkopić, L, Brcic, L, Brcic, I, Kolenc, D, Seiwerth, S, Sikiric P   +13 more
openaire   +3 more sources

Esophageal Cytoprotection in Rats. Stable Gastric Pentadecapeptide BPC 157 and Omeprazole

The FASEB Journal, 2017
Aim Up to now, esophagus, as a direct target, is not particularly concerned in stomach cytoprotection studies performed with direct instillation of the nocuous agent in the rat stomach (Curr Pharm Des 2010;16(10):1224–34).
Peklic, Marina, Boban Blagaic, Alenka, Becejac, Tomislav, Suran, Jelena, Drmic, Domagoj, Seiwerth, Sven, Sikiric, Predrag   +6 more
openaire   +2 more sources

Caustic Lesions of Esophagus in Rats and Therapy with Stable Gastric Pentadecapeptide BPC 157

The FASEB Journal, 2018
Aim We focused on caustic lesions of the esophagus in rat and therapy with the stable gastric pentadecapeptide BPC 157. Caustic lesions of the esophagus are one of the life‐threatening morbidities after ingestion of acid or alkali, as an accidental ingestion affecting mostly children.
Peklic, Marina, Drmic, Domagoj, Pavlov, Katarina Horvat, Blagaic, Alenka Boban, Seiwerth, Sven, Sikiric, Predrag   +5 more
openaire   +2 more sources

Unilateral Adrenalectomy, and the Stable Pentadecapeptide BPC 157 as Therapy in Rats—A Cytoprotection Approach

Pharmaceuticals
Background. This rat study reveals a new point: the considerable impact of unilateral adrenalectomy, severe vascular and multiorgan failure, occlusion/occlusion-like syndrome, and the stable gastric pentadecapeptide BPC 157 therapy.
Ivan Maria Smoday, Vlasta Vukovic, Katarina Oroz, Hrvoje Vranes, Luka Kalogjera, Ozren Gamulin, Josipa Vlainic, Marija Milavic, Suncana Sikiric, Nora Nikolac Gabaj, Domagoj Marijancevic, Antun Koprivanac, Laura Tomic, Sanja Strbe, Ivan Barisic, Lidija Beketic Oreskovic, Mario Kordic, Ante Tvrdeic, Sven Seiwerth, Predrag Sikiric, Alenka Boban Blagaic, Anita Skrtic   +21 more
doaj   +1 more source

Stable Gastric Pentadecapeptide BPC 157 Antagonized Local Anesthetic Effect of Lidocaine

The FASEB Journal, 2019
We documented that the stable gastric pentadecapeptide BPC 157 antagonized local anaesthetic effect of lidocaine. BPC 157 (LD1 not achieved) was implemented as an anti‐ulcer peptide in inflammatory bowel disease trials and now in a multiple sclerosis trial (Curr Pharm Des. 2018;24(18):1990–2001).
Lozic, Marin, Stambolija, Vasilije, Kovacevic, Josip, Zivanovic‐Posilovic, Gordana, Suran, Jelena, Duplancic, Bozidar, Mirkovic, Ivan, Kokot, Antonio, Drmic, Domagoj, Seiwerth, Sven, Sikiric, Predrag   +10 more
openaire   +1 more source

Stomach perforation-induced general occlusion/occlusion-like syndrome and stable gastric pentadecapeptide BPC 157 therapy effect. [PDF]

World J Gastroenterol, 2023
Kalogjera L, Krezic I, Smoday IM, Vranes H, Zizek H, Yago H, Oroz K, Vukovic V, Kavelj I, Novosel L, Zubcic S, Barisic I, Beketic Oreskovic L, Strbe S, Sever M, Sjekavica I, Skrtic A, Boban Blagaic A, Seiwerth S, Sikiric P.   +19 more
europepmc   +1 more source