Results 41 to 50 of about 2,190,716 (112)

Cytoprotection as a Unifying Strategy for Hemorrhage and Thrombosis: The Role of BPC 157 and Related Therapeutics [PDF]

Pharmaceuticals
This review presents an innovative and timely exploration of how cytoprotection can serve as a cohesive therapeutic approach by which to address the hemorrhage–thrombosis paradox.
Predrag Sikiric, Ivan Barisic, Mario Udovicic, Martina Lovric Bencic, Diana Balenovic, Dean Strinic, Gordana Zivanovic Posilovic, Sandra Uzun, Hrvoje Vranes, Ivan Krezic, Marin Lozic, Vasilije Stambolija, Ivica Premuzic Mestrovic, Lidija Beketic Oreskovic, Luka Kalogjera, Sanja Strbe, Suncana Sikiric, Laura Tomic, Mirjana Stupnisek, Mario Kordic, Ante Tvrdeic, Sven Seiwerth, Alenka Boban Blagaic, Anita Skrtic   +23 more
doaj   +2 more sources

Stomach perforation-induced general occlusion/occlusion-like syndrome and stable gastric pentadecapeptide BPC 157 therapy effect. [PDF]

World J Gastroenterol, 2023
Background: Using rat stomach perforation as a prototypic direct lesion applied in cytoprotection research, we focused on the first demonstration of the severe occlusion/ occlusion-like syndrome induced by stomach perforation.
Kalogjera L, Krezic I, Smoday IM, Vranes H, Zizek H, Yago H, Oroz K, Vukovic V, Kavelj I, Novosel L, Zubcic S, Barisic I, Beketic Oreskovic L, Strbe S, Sever M, Sjekavica I, Skrtic A, Boban Blagaic A, Seiwerth S, Sikiric P.   +19 more
europepmc   +2 more sources

Challenge of Corneal Ulcer Healing: A Novel Conceptual Framework, the “Triad” of Corneal Ulcer Healing/Corneal Neovascularization/Intraocular Pressure, and Avascular Tendon Healing, for Evaluation of Corneal Ulcer Therapy, Therapy of Neovascularization, Glaucoma Therapy, and Pentadecapeptide BPC 157 Efficacy [PDF]

Pharmaceuticals
To better address the challenge of corneal ulcer healing, with already available standard agents, and those recently introduced, such as stable gastric pentadecapeptide BPC 157, we introduced a novel conceptual framework—the “triad” of corneal ulcer ...
Sanja Masnec, Antonio Kokot, Tamara Kralj, Mirna Zlatar, Kristina Loncaric, Marko Sablic, Miro Kalauz, Iva Beslic, Katarina Oroz, Bozana Mrvelj, Lidija Beketic Oreskovic, Ivana Oreskovic, Sanja Strbe, Borna Staresinic, Goran Slivsek, Alenka Boban Blagaic, Sven Seiwerth, Anita Skrtic, Predrag Sikiric   +18 more
doaj   +2 more sources

Stable gastric pentadecapeptide BPC 157

Journal of physiology and pharmacology, 2009
Considering peptidergic drugs, many cytokines, enzymes, clotting factors registered for the use as therapeutic agents in specific conditions, they are mainly given by injection, only occasionally by other routes. Also, to ascertain delivery and activity, they use different carriers, peptide+carrier complex may provide significant methodology/activity ...
Sikirić, Predrag, Seiwerth, Sven, Ručman, Rudolf, Turković, Branko   +3 more
  +9 more sources

Antinociceptive Effect of BPC-157 in the Formalin-induced Pain Model [PDF]

Kosin Medical Journal, 2021
Objectives Body protective compound-157 (BPC-157) is a stable gastric pentadecapeptide that has been effective in trials aiming to increase wound healing capabilities and decrease inflammatory cell influx, including studies on the healing of muscles and ...
Sang Yoong Park, So Ron Choi, Jeong Ho Kim, Seung Cheol Lee, Seong Yeop Jeong, Joon Ho Jeong, Tae Young Lee   +6 more
doaj   +1 more source

Pentadecapeptide BPC 157 as Therapy for Inferior Caval Vein Embolization: Recovery of Sodium Laurate-Post-Embolization Syndrome in Rats

Pharmaceuticals, 2023
After inferior caval vein embolization therapy, post-embolization syndrome (sodium laurate 10 mg/kg, 0.1 mL into rat inferior caval vein, assessment at 15, 30, 60 min, prime lung lesions, thromboemboli occluding lung vessels), as a severe occlusion ...
Ivan Maria Smoday, Ivan Krezic, Luka Kalogjera, Vlasta Vukovic, Helena Zizek, Marija Skoro, Katarina Kasnik Kovac, Hrvoje Vranes, Ivan Barisic, Suncana Sikiric, Sanja Strbe, Marijan Tepes, Katarina Oroz, Slavica Zubcic, Mirjana Stupnisek, Lidija Beketic Oreskovic, Ivana Kavelj, Luka Novosel, Matea Prenc, Sanja Barsic Ostojic, Ivan Dobric, Marko Sever, Alenka Boban Blagaic, Anita Skrtic, Mario Staresinic, Ivica Sjekavica, Sven Seiwerth, Predrag Sikiric   +27 more
doaj   +1 more source

In relation to NO‐System, Stable Pentadecapeptide BPC 157 Counteracts Lidocaine‐Induced Adverse Effects in Rats and Depolarisation In Vitro

Emergency Medicine International, Volume 2020, Issue 1, 2020., 2020
Recently, the pentadecapeptide BPC 157‐induced counteraction of bupivacaine cardiotoxicity has been reported. Medication includes (i) lidocaine‐induced local anesthesia via intraplantar application and axillary and spinal (L4‐L5) intrathecal block, (ii) lidocaine‐induced arrhythmias, (iii) convulsions, and (iv) lidocaine‐induced HEK293 cell ...
Marin Lozic, Vasilije Stambolija, Ivan Krezic, Aleksandra Dugandzic, Gordana Zivanovic-Posilovic, Slaven Gojkovic, Josip Kovacevic, Luka Vrdoljak, Ivan Mirkovic, Antonio Kokot, Andreja Petrovic, Katarina Horvat Pavlov, Domagoj Drmic, Jelena Suran, Alenka Boban Blagaic, Sven Seiwerth, Predrag Sikiric, Chak W. Kam   +17 more
wiley   +1 more source

Pentadecapeptide BPC 157, in Clinical Trials as a Therapy for Inflammatory Bowel Disease (PL14736), Is Effective in the Healing of Colocutaneous Fistulas in Rats: Role of the Nitric Oxide-System

Journal of Pharmacological Sciences, 2008
We focused on the therapeutic effect of the stable gastric pentadecapeptide BPC 157 and how its action is related to nitric oxide (NO) in persistent colocutaneous fistula in rats (at 5 cm from anus, colon defect of 5 mm, skin defect of 5 mm); this ...
Robert Klicek, Marko Sever, Bozo Radic, Domagoj Drmic, Ivan Kocman, Ivan Zoricic, Tihomir Vuksic, Mihovil Ivica, Ivan Barisic, Spomenko Ilic, Lidija Berkopic, Hrvoje Vrcic, Luka Brcic, Alenka Boban Blagaic, Marijana Coric, Iva Brcic, Dinko Stancic Rokotov, Tomislav Anic, Sven Seiwerth, Predrag Sikiric   +19 more
doaj   +1 more source

Pentadecapeptide BPC 157 Reduces Bleeding and Thrombocytopenia after Amputation in Rats Treated with Heparin, Warfarin, L-NAME and L-Arginine. [PDF]

PLoS ONE, 2015
BPC 157 is a stable gastric pentadecapeptide recently implicated with a role in hemostasis. While NO is largely implicated in hemostatic mechanisms, in tail-amputation-models under heparin- and warfarin-administration, both the NO-synthase (NOS)-blocker,
Mirjana Stupnisek, Antonio Kokot, Domagoj Drmic, Masa Hrelec Patrlj, Anita Zenko Sever, Danijela Kolenc, Bozo Radic, Jelena Suran, Davor Bojic, Aleksandar Vcev, Sven Seiwerth, Predrag Sikiric   +11 more
doaj   +1 more source

ISOSORBIDE-5-MONONITRATE INDUCED PERIPHERAL AND CENTRAL VASCULAR DYSFUNCTION IN RATS AND TRETMENT WITH STABLE GASTRIC PENTADECAPEPTIDE BPC 157 [PDF]

, 2023
Introduction: Although the understanding of migraine pathophysiology is incomplete, it is now well accepted that this neurovascular syndrome is mainly due to cranial vasodilation.
Kalogjera, Luka, Vuković, Vlasta, Vraneš, Hrvoje   +2 more
core   +1 more source