Results 201 to 210 of about 15,919 (247)
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Development of stable isotope dilution assays for ochratoxin A in blood samples
Analytical Biochemistry, 2011Two new stable isotope dilution assays were developed for the quantification of ochratoxin A in human blood samples for exposure studies. The methods based on two different sample extraction and cleanup procedures including liquid-liquid extraction with following immunoaffinity chromatography (IA) as well as a dispersive solid-phase extraction (DSPE ...
Markus, Korn +3 more
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Journal of Agricultural and Food Chemistry, 2021
The first multiple stable isotope dilution assay method was developed for the simultaneous determination of four cobalamins, namely, hydroxocobalamin (OHCbl), adenosylcobalamin (AdoCbl), methylcobalamin (MeCbl), and cyanocobalamin (CNCbl), in their native forms. The sample preparation was optimized with enzyme treatment and immunoaffinity purification.
Mengle Wang +3 more
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The first multiple stable isotope dilution assay method was developed for the simultaneous determination of four cobalamins, namely, hydroxocobalamin (OHCbl), adenosylcobalamin (AdoCbl), methylcobalamin (MeCbl), and cyanocobalamin (CNCbl), in their native forms. The sample preparation was optimized with enzyme treatment and immunoaffinity purification.
Mengle Wang +3 more
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Quantification of the mycotoxins patulin and ochratoxin A by stable isotope dilution assays
Mycotoxin Research, 2005For analysis of trace compounds, stable isotope dilution assays (SIDAs) have gained increasing importance in the past years. This methodology is based on the use of stable isotopically labelled analogues of the analytes as internal standards (IS). To take the mycotoxins patulin and ochratoxin A as examples, the benefits of SIDAs were demonstrated both ...
M, Rychlik +5 more
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A stable isotope dilution assay for the antiparkinsonian drug benztropine in biological fluids
Clinica Chimica Acta, 1981A quantitative gas chromatographic-mass spectrometric (GC-MS) assay was developed for the determination of benztropine in human urine and plasma. The assay utilizes selected ion focusing to monitor in a GC effluent a specific fragment ion of benztropine generated by electron-impact ionization. Benztropine-d3 was the internal standard.
S P, Jindal +3 more
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Stable Isotope Dilution Assays of Alternariol and Alternariol Monomethyl Ether in Beverages
Journal of Agricultural and Food Chemistry, 2009Stable isotope dilution assays (SIDAs) for the determination of the most important mycotoxins of the black mold Alternaria, namely, alternariol and alternariol monomethyl ether, have been developed. For this purpose, deuterated alternariol and alternariol methyl ether were synthesized by palladium catalyzed protium-deuterium exchange from the unlabeled
Stefan, Asam +3 more
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Development of Stable Isotope Dilution Assays for the Quantitation of Amadori Compounds in Foods
Journal of Agricultural and Food Chemistry, 2014During thermal processing of foods, reducing carbohydrates and amino acids may form 1-amino-1-desoxyketoses named Amadori rearrangement products after the Italian chemist Mario Amadori. Although these compounds are transient intermediates of the Maillard reaction, they are often used as suitable markers to measure the extent of a thermal food ...
Michael, Meitinger +2 more
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Synthesis of Deuterated γ-Lactones for Use in Stable Isotope Dilution Assays
Journal of Agricultural and Food Chemistry, 2004Two syntheses of deuterated gamma-lactones for use as internal standards in stable isotope dilution assays (SIDA) were developed. [2,2,3,3-2H4]-gamma-Octa-, -gamma-deca-, and -gamma-dodecalactones with >89% deuterium incorporation were prepared in 27, 17, and 19% overall yields, respectively, by the reduction of a doubly protected hydroxypropiolic acid
Jo-Anna, Hislop +3 more
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Journal of Agricultural and Food Chemistry, 2013
Stable isotope dilution assays (SIDA) provide for accurate and precise quantitation of aroma components, such as alkylpyrazines, which are often present in low concentrations in complex food matrices. The unavailability of labeled standards is the main limitation to the widespread use of SIDA.
Mingchih, Fang, Keith R, Cadwallader
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Stable isotope dilution assays (SIDA) provide for accurate and precise quantitation of aroma components, such as alkylpyrazines, which are often present in low concentrations in complex food matrices. The unavailability of labeled standards is the main limitation to the widespread use of SIDA.
Mingchih, Fang, Keith R, Cadwallader
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Quantification of Pantothenic Acid and Folates by Stable Isotope Dilution Assays
Journal of Food Composition and Analysis, 2002Abstract Stable isotope dilution assays for the quantification of pantothenic acid and folates in foods by using four-fold labeled isotopomers of the vitamins as internal standards (IS) were developed. The use of labeled IS enabled to exactly correct losses during cleanup and derivatization.
Michael Rychlik, Achim Freisleben
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Studies on accuracy of trichothecene multitoxin analysis using stable isotope dilution assays
Mycotoxin Research, 2007Critical parameters in mycotoxin analysis were examined by using stable isotope-labelled tricho-thecenes. Sample weight was downsized to 1 g without loosing precision when sufficiently homogenized samples were taken for analysis. Complete extraction of trichothecenes could be achieved with a solvent mixture of acetonitrile+water (84+16; v+v) even ...
S, Asam, M, Rychlik
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