Superactivation of AMPA receptors by auxiliary proteins [PDF]
Nature Communications, 2016 Transmembrane AMPA receptor regulatory proteins (TARPs) exert a number of effects on fast glutamatergic synaptic transmission. Here, the authors model the interactions of two such proteins, Stargazin and γ-8, and propose a simple kinetic mechanism by ...
Anna L. Carbone, Andrew J. R. Plested
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The tetraspanin TSPAN5 regulates AMPAR exocytosis by interacting with the AP4 complex [PDF]
eLife, 2023 Intracellular trafficking of AMPA receptors is a tightly regulated process which involves several adaptor proteins, and is crucial for the activity of excitatory synapses both in basal conditions and during synaptic plasticity.
Edoardo Moretto +7 more
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Molecular cloning of the gene promoter encoding the human CaVγ2/Stargazin divergent transcript (CACNG2-DT): characterization and regulation by the cAMP-PKA/CREB signaling pathway [PDF]
Frontiers in Physiology, 2023 CaVγ2 (Stargazin or TARPγ2) is a protein expressed in various types of neurons whose function was initially associated with a decrease in the functional expression of voltage-gated presynaptic Ca2+ channels (CaV) and which is now known to promote the ...
David Muñoz-Herrera +9 more
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Exploring the impact of the stargazin V143L mutation on the dynamics of the AMPA receptor: stargazin complex [PDF]
Frontiers in Cellular NeuroscienceStargazin, a transmembrane AMPAR regulatory protein (TARP), plays a crucial role in facilitating the transport of AMPA receptors to the cell surface, stabilising their localisation at synapses and influencing their gating properties.
Raquel P. Gouveia +8 more
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Visualizing Arc protein dynamics and localization in the mammalian brain using AAV-mediated in situ gene labeling [PDF]
Frontiers in Molecular Neuroscience, 2023 The activity-regulated cytoskeleton-associated (Arc) protein is essential for synaptic plasticity and memory formation. The Arc gene, which contains remnants of a structural GAG retrotransposon sequence, produces a protein that self-assembles into capsid-
Martino Avallone +13 more
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Targeted sensors for glutamatergic neurotransmission [PDF]
eLife, 2023 Optical report of neurotransmitter release allows visualisation of excitatory synaptic transmission. Sensitive genetically-encoded fluorescent glutamate reporters operating with a range of affinities and emission wavelengths are available.
Yuchen Hao +4 more
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Caspase-1/IL-1β represses membrane transport of GluA1 by inhibiting the interaction between Stargazin and GluA1 in Alzheimer’s disease [PDF]
Molecular Medicine, 2021 Background Alzheimer's disease is a neurodegenerative disease. Previous study has reported that caspase-1/IL-1β is closely associated with Alzheimer's disease.
Xunhu Gu +5 more
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The Impact of Glutamatergic Synapse Dysfunction in the Corticothalamocortical Network on Absence Seizure Generation [PDF]
Frontiers in Molecular Neuroscience, 2022 Childhood absence epilepsy (CAE) is the most common pediatric epilepsy affecting 10–18% of all children with epilepsy. It is genetic in origin and the result of dysfunction within the corticothalamocortical (CTC) circuitry.
Beulah Leitch
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Regulation of the Stability and Localization of Post-synaptic Membrane Proteins by Liquid-Liquid Phase Separation [PDF]
Frontiers in Physiology, 2021 Synaptic plasticity is a cellular mechanism of learning and memory. The synaptic strength can be persistently upregulated or downregulated to update the information sent to the neuronal network and form a memory engram.
Tomohisa Hosokawa, Pin-Wu Liu
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iScience, 2021 Summary: Postsynaptic density protein 95 is a key scaffolding protein in the postsynaptic density of excitatory glutamatergic neurons, organizing signaling complexes primarily via its three PSD-95/Discs-large/Zona occludens domains.
Maria Vistrup-Parry +10 more
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