Exploring the impact of the stargazin V143L mutation on the dynamics of the AMPA receptor: stargazin complex [PDF]
Frontiers in Cellular NeuroscienceStargazin, a transmembrane AMPAR regulatory protein (TARP), plays a crucial role in facilitating the transport of AMPA receptors to the cell surface, stabilising their localisation at synapses and influencing their gating properties.
Raquel P. Gouveia +8 more
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Stargazin Dephosphorylation Mediates Homeostatic Synaptic Downscaling of Excitatory Synapses [PDF]
Frontiers in Molecular Neuroscience, 2018 Synaptic scaling is a form of homeostatic plasticity that is critical for maintaining neuronal activity within a dynamic range, and which alters synaptic strength through changes in postsynaptic AMPA-type glutamate receptors.
Susana R. Louros +3 more
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Molecular cloning of the gene promoter encoding the human CaVγ2/Stargazin divergent transcript (CACNG2-DT): characterization and regulation by the cAMP-PKA/CREB signaling pathway [PDF]
Frontiers in Physiology, 2023 CaVγ2 (Stargazin or TARPγ2) is a protein expressed in various types of neurons whose function was initially associated with a decrease in the functional expression of voltage-gated presynaptic Ca2+ channels (CaV) and which is now known to promote the ...
David Muñoz-Herrera +9 more
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The tetraspanin TSPAN5 regulates AMPAR exocytosis by interacting with the AP4 complex [PDF]
eLife, 2023 Intracellular trafficking of AMPA receptors is a tightly regulated process which involves several adaptor proteins, and is crucial for the activity of excitatory synapses both in basal conditions and during synaptic plasticity.
Edoardo Moretto +7 more
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Visualizing Arc protein dynamics and localization in the mammalian brain using AAV-mediated in situ gene labeling [PDF]
Frontiers in Molecular Neuroscience, 2023 The activity-regulated cytoskeleton-associated (Arc) protein is essential for synaptic plasticity and memory formation. The Arc gene, which contains remnants of a structural GAG retrotransposon sequence, produces a protein that self-assembles into capsid-
Martino Avallone +13 more
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Human neuronal stargazin-like proteins, γ2, γ3 and γ4; an investigation of their specific localization in human brain and their influence on CaV2.1 voltage-dependent calcium channels expressed in
BMC Neuroscience, 2003 Background Stargazin (γ2) and the closely related γ3, and γ4 transmembrane proteins are part of a family of proteins that may act as both neuronal voltage-dependent calcium channel (VDCC) γ subunits and transmembrane α-amino-3-hydroxy-5-methyl-4 ...
Dolphin Annette C +2 more
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Molecular physiology of Arc/Arg3.1: The oligomeric state hypothesis of synaptic plasticity. [PDF]
Acta Physiol (Oxf), 2022 Abstract The immediate early gene, Arc, is a pivotal regulator of synaptic plasticity, memory, and cognitive flexibility. But what is Arc protein? How does it work? Inside the neuron, Arc is a protein interaction hub and dynamic regulator of intra‐cellular signaling in synaptic plasticity.
Eriksen MS, Bramham CR.
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Autoinactivation of the stargazin-AMPA receptor complex: subunit-dependency and independence from physical dissociation. [PDF]
PLoS ONE, 2012 Agonist responses and channel kinetics of native α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors are modulated by transmembrane accessory proteins.
Artur Semenov +4 more
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Genetic absence epilepsy rats from Strasbourg have increased corticothalamic expression of stargazin [PDF]
Neurobiology of Disease, 2008 Stargazin is membrane bound protein involved in trafficking, synapse anchoring and biophysical modulation of AMPA receptors. A quantitative trait locus in chromosome 7 containing the stargazin gene has been identified as controlling the frequency and ...
K.L. Powell +7 more
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Targeted sensors for glutamatergic neurotransmission [PDF]
eLife, 2023 Optical report of neurotransmitter release allows visualisation of excitatory synaptic transmission. Sensitive genetically-encoded fluorescent glutamate reporters operating with a range of affinities and emission wavelengths are available.
Yuchen Hao +4 more
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