Exploring the impact of the stargazin V143L mutation on the dynamics of the AMPA receptor: stargazin complex [PDF]
Frontiers in Cellular NeuroscienceStargazin, a transmembrane AMPAR regulatory protein (TARP), plays a crucial role in facilitating the transport of AMPA receptors to the cell surface, stabilising their localisation at synapses and influencing their gating properties.
Raquel P. Gouveia +8 more
doaj +6 more sources
Stargazin Modulation of AMPA Receptors [PDF]
Cell Reports, 2016 Fast excitatory synaptic signaling in the mammalian brain is mediated by AMPA-type ionotropic glutamate receptors. In neurons, AMPA receptors co-assemble with auxiliary proteins, such as stargazin, which can markedly alter receptor trafficking and gating.
Sana A. Shaikh +7 more
doaj +6 more sources
Molecular cloning of the gene promoter encoding the human CaVγ2/Stargazin divergent transcript (CACNG2-DT): characterization and regulation by the cAMP-PKA/CREB signaling pathway [PDF]
Frontiers in Physiology, 2023 CaVγ2 (Stargazin or TARPγ2) is a protein expressed in various types of neurons whose function was initially associated with a decrease in the functional expression of voltage-gated presynaptic Ca2+ channels (CaV) and which is now known to promote the ...
David Muñoz-Herrera +9 more
doaj +5 more sources
A Role for Stargazin in Experience-Dependent Plasticity [PDF]
Cell Reports, 2014 During development, neurons are constantly refining their connections in response to changes in activity. Experience-dependent plasticity is a key form of synaptic plasticity, involving changes in α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ...
Susana R. Louros +4 more
doaj +6 more sources
Caspase-1/IL-1β represses membrane transport of GluA1 by inhibiting the interaction between Stargazin and GluA1 in Alzheimer’s disease [PDF]
Molecular Medicine, 2021 Background Alzheimer's disease is a neurodegenerative disease. Previous study has reported that caspase-1/IL-1β is closely associated with Alzheimer's disease.
Xunhu Gu +5 more
doaj +4 more sources
Molecular Mechanism of AMPA Receptor Modulation by TARP/Stargazin [PDF]
Neuron, 2017 AMPA receptors (AMPARs) mediate the majority of fast excitatory transmission in the brain and critically contribute to synaptic plasticity and pathology. AMPAR trafficking and gating are tightly controlled by auxiliary transmembrane AMPAR regulatory proteins (TARPs).
Anat Ben-Yaacov +5 more
semanticscholar +4 more sources
Stargazin Dephosphorylation Mediates Homeostatic Synaptic Downscaling of Excitatory Synapses [PDF]
Frontiers in Molecular Neuroscience, 2018 Synaptic scaling is a form of homeostatic plasticity that is critical for maintaining neuronal activity within a dynamic range, and which alters synaptic strength through changes in postsynaptic AMPA-type glutamate receptors.
Susana R. Louros +3 more
doaj +5 more sources
Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy [PDF]
Science, 2016 Stargazin and the AMPA receptor AMPA-subtype ionotropic glutamate receptors (AMPARs) mediate fast excitatory neurotransmission and contribute to higher cognitive processes such as learning and memory. In the brain, AMPARs exist as protein-protein complexes with various auxiliary subunits that tightly control AMPAR trafficking ...
E. C. Twomey +4 more
semanticscholar +5 more sources
Slow AMPAR Synaptic Transmission Is Determined by Stargazin and Glutamate Transporters [PDF]
Neuron, 2017 AMPARs mediate the briefest synaptic currents in the brain by virtue of their rapid gating kinetics. However, at the mossy fiber-to-unipolar brush cell synapse in the cerebellum, AMPAR-mediated EPSCs last for hundreds of milliseconds, and it has been proposed that this time course reflects slow diffusion from a complex synaptic space. We show that upon
H. Lu +3 more
semanticscholar +4 more sources
Serine Racemase Regulated by Binding to Stargazin and PSD-95 [PDF]
Journal of Biological Chemistry, 2014 Background: d-Serine, generated by serine racemase (SR), is an endogenous co-agonist for NMDA receptors. Results: SR binds PSD-95 and stargazin, which inhibits SR enzymatic activity.
T. Ma +7 more
semanticscholar +4 more sources