Results 41 to 50 of about 1,323 (153)

Ca2+‐permeable AMPA receptors and their auxiliary subunits in synaptic plasticity and disease

open access: yesThe Journal of Physiology, Volume 599, Issue 10, Page 2655-2671, 15 May 2021., 2021
Abstract figure legend AMPARs containing GluA2 (red subunits) are Ca2+‐impermeable (CI‐AMPARs). Those that lack GluA2 are Ca2+‐permeable (CP‐AMPARs) and are implicated in diverse forms of synaptic plasticity and disease. Both native CP‐ and CI‐AMPARs contain various auxiliary subunits (shown as yellow, green or turquoise) that affect AMPAR function and
Stuart G. Cull‐Candy, Mark Farrant
wiley   +1 more source

High-affinity anti-Arc nanobodies provide tools for structural and functional studies.

open access: yesPLoS ONE, 2022
Activity-regulated cytoskeleton-associated protein (Arc) is a multidomain protein of retroviral origin with a vital role in the regulation of synaptic plasticity and memory formation in mammals.
Sigurbjörn Markússon   +9 more
doaj   +3 more sources

Functional genomic analyses highlight a shift in Gpr17‐regulated cellular processes in oligodendrocyte progenitor cells and underlying myelin dysregulation in the aged mouse cerebrum

open access: yesAging Cell, Volume 20, Issue 4, April 2021., 2021
Ageing reduces the number of OPCs and their ‘stemness’. Genomic analysis resolved key mechanisms underpinning the age related decline in OPCs, most notably reduced expression of Gpr17 in a subpopulation of differentiation committed OPCs. Pharmacogenomics identified small molecules that have the potential to rejuvenate OPCs and promote myelination and ...
Andrea D. Rivera   +6 more
wiley   +1 more source

Stargazin Reduces Desensitization and Slows Deactivation of the AMPA-Type Glutamate Receptors [PDF]

open access: hybridThe Journal of Neuroscience, 2005
The AMPA-type glutamate receptors mediate the majority of the fast excitatory synaptic transmission and critically contribute to synaptic plasticity in the brain, hence the existence of numerous trafficking proteins dedicated to regulation of their synaptic delivery and turnover.
Avi Priel   +5 more
openalex   +6 more sources

Calpain-mediated regulation of stargazin in adult rat brain [PDF]

open access: yesNeuroscience, 2011
Changes in AMPA receptors have been proposed to underlie changes in synaptic efficacy in hippocampus and other brain structures. Calpain activation has also been discussed as a potential mechanism to produce lasting modifications of synaptic structure and function.
Yi Wang   +5 more
openaire   +3 more sources

mRNA Trafficking in the Nervous System: A Key Mechanism of the Involvement of Activity‐Regulated Cytoskeleton‐Associated Protein (Arc) in Synaptic Plasticity

open access: yesNeural Plasticity, Volume 2021, Issue 1, 2021., 2021
Synaptic activity mediates information storage and memory consolidation in the brain and requires a fast de novo synthesis of mRNAs in the nucleus and proteins in synapses. Intracellular localization of a protein can be achieved by mRNA trafficking and localized translation. Activity‐regulated cytoskeleton‐associated protein (Arc) is a master regulator
Michal Fila   +5 more
wiley   +1 more source

Screening for AMPA receptor auxiliary subunit specific modulators. [PDF]

open access: yesPLoS ONE, 2017
AMPA receptors (AMPAR) are ligand gated ion channels critical for synaptic transmission and plasticity. Their dysfunction is implicated in a variety of psychiatric and neurological diseases ranging from major depressive disorder to amyotrophic lateral ...
Caleigh M Azumaya   +6 more
doaj   +1 more source

Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy [PDF]

open access: yesScience, 2016
Stargazin and the AMPA receptor AMPA-subtype ionotropic glutamate receptors (AMPARs) mediate fast excitatory neurotransmission and contribute to higher cognitive processes such as learning and memory. In the brain, AMPARs exist as protein-protein complexes with various auxiliary subunits that tightly control AMPAR trafficking ...
Edward C. Twomey   +5 more
openaire   +3 more sources

Expression and Interaction Proteomics of GluA1- and GluA3-Subunit-Containing AMPARs Reveal Distinct Protein Composition

open access: yesCells, 2022
The AMPA glutamate receptor (AMPAR) is the major type of synaptic excitatory ionotropic receptor in the brain. AMPARs have four different subunits, GluA1–4 (each encoded by different genes, Gria1, Gria2, Gria3 and Gria4), that can form distinct ...
Sophie J. F. van der Spek   +7 more
doaj   +1 more source

Synaptic Changes in AMPA Receptor Subunit Expression in Cortical Parvalbumin Interneurons in the Stargazer Model of Absence Epilepsy

open access: yesFrontiers in Molecular Neuroscience, 2017
Feedforward inhibition is essential to prevent run away excitation within the brain. Recent evidence suggests that a loss of feed-forward inhibition in the corticothalamocortical circuitry may underlie some absence seizures.
Nadia K. Adotevi, Beulah Leitch
doaj   +1 more source

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