Results 41 to 50 of about 2,576 (168)

Synaptic AMPA receptor composition in development, plasticity and disease [PDF]

, 2016
AMPA receptors (AMPARs) are assemblies of four core subunits, GluA1–4, that mediate most fast excitatory neurotransmission. The component subunits determine the functional properties of AMPARs, and the prevailing view is that the subunit composition also
A Citri, A Constals, A Goel, A Goel, A Nishimune, A Semenov, A Sumioka, A Terashima, A Wright, AC Jackson, AC Jackson, AJ Granger, AJ Granger, AJ Granger, AL Mammen, AS Kristensen, B Sommer, BE Herring, C Bats, C Bats, C Bellone, C Bellone, C Bokel, CH Kim, CY Tai, D Mauceri, D Nair, D Soto, D Soto, D Studniarczyk, D Zamanillo, DA Fortin, DE Pellegrini-Giampietro, DJ Whitcomb, DM Walsh, DT Lin, E Kalashnikova, E Sauvageau, E Schnell, E Suzuki, EE Gray, EM Petrini, ES Guire, F Ogoshi, GG Turrigiano, GH Diering, GJ Soler-Llavina, GM Shankar, H Adesnik, H Dong, H Hampel, H Makino, H Monyer, H Wu, HD MacGillavry, HK Lee, HK Lee, HK Lee, HW Kessels, HY Man, ID Coombs, IH Greger, IH Greger, IH Greger, IH Greger, J Aoto, J Boehm, J Schwenk, J von Engelhardt, JA Esteban, JD Shepherd, Jeremy M. Henley, JG Hanley, JJ Zhu, JL Sanderson, JM Henley, JM Henley, JM Kerr, JM Spaethling, JP Steinberg, JQ Wang, JR Brorson, JT Isaac, K Archibald, K He, K Plant, KA Pelkey, Kevin A. Wilkinson, KL Conrad, KW Roche, L Chen, L Kelly, L Pickard, L Saglietti, L Volk, LS Loo, M Carta, M Morimoto-Tomita, M Rossmann, M Sheng, M Sukumaran, MA Gainey, MA Sutton, MG Blair, ML Mayer, MS Washburn, MT Ho, MW Linhoff, N Harmel, N Jaafari, N Sans, NF Shanks, NJ Allen, NK Hussain, NV Luchkina, P Farrow, P Opazo, P Opazo, P Steiner, PJ Brockie, RA Nicoll, RJ Wenthold, RL Clem, RL Clem, RL Huganir, S Cull-Candy, S Hestrin, S Kim, S Shi, S Tomita, S Tomita, S Tomita, SC Haering, SH Lee, SJ Liu, SJ Liu, SJ Mah, SM Gardner, SQ Liu, SS Kumar, SY Grooms, T Hosokawa, T Nakagawa, T Nakagawa, T Yamashita, TA Verdoorn, TC Thiagarajan, TE Chater, TG Banke, V Bernard, W Lu, W Lu, W Lu, W Vandenberghe, W Wisden, WQ Zhao, Y Hayashi, Y Kawahara, Y Yang, Y Zheng   +159 more
core   +3 more sources

Pentraxins coordinate excitatory synapse maturation and circuit integration of parvalbumin interneurons [PDF]

, 2017
This is the author accepted manuscript. The final version is available from the publisher via the DOI in this record.Circuit computation requires precision in the timing, extent, and synchrony of principal cell (PC) firing that is largely enforced by ...
Barksdale, E, Cameron, HA, Chittajallu, R, Colonnese, MT, Craig, MT, Karlsson, R-M, McBain, CJ, Mitchell, RM, Murata, Y, Pelkey, KA, Petralia, RS, Sukumaran, M, Vargish, GA, Worley, PF, Wyeth, MS, Yuan, X   +15 more
core   +1 more source

Mechanism of Modulation of AMPA Receptors by Stargazin [PDF]

Biophysical Journal, 2014
AMPA receptors (AMPARs) mediate most of the fast excitatory synaptic transmission in the brain. Native AMPARs typically form heterotetrameric complexes and associate with a variety of auxiliary subunits. Stargazin (gamma2) is the prototype and most studied member of the transmembrane AMPA receptor regulatory proteins family, and regulates several ...
Carbone, Anna L., Plested, Andrew J.
openaire   +1 more source

Synaptic Changes in AMPA Receptor Subunit Expression in Cortical Parvalbumin Interneurons in the Stargazer Model of Absence Epilepsy

Frontiers in Molecular Neuroscience, 2017
Feedforward inhibition is essential to prevent run away excitation within the brain. Recent evidence suggests that a loss of feed-forward inhibition in the corticothalamocortical circuitry may underlie some absence seizures.
Nadia K. Adotevi, Beulah Leitch
doaj   +1 more source

TARP γ-7 selectively enhances synaptic expression of calcium-permeable AMPARs [PDF]

, 2013
Regulation of calcium-permeable AMPA receptors (CP-AMPARs) is crucial in normal synaptic function and neurological disease states. Although transmembrane AMPAR regulatory proteins (TARPs) such as stargazin (γ-2) modulate the properties of calcium ...
A Priel, A Rozov, AC Jackson, AS Kato, AS Kato, B Liu, B Sommer, C Bats, C Bats, C Chung, CA Schneider, CH Cho, D Bowie, D Soto, D Soto, D Turetsky, D Yan, Dorota Studniarczyk, HY Man, Ian Coombs, J Mosbacher, J Schwenk, JJ Rosenthal, JR Geiger, JS Park, JT Isaac, K Hashimoto, K Menuz, KS Kim, L Cathala, L Chen, L Ferron, M Blaschke, M Fukaya, M Hollmann, M Koike, M Passafaro, M Yamazaki, MA Bedoukian, Mark Farrant, MS Washburn, N Burnashev, N Rouach, R Kuner, S Cull-Candy, S Kott, S Tomita, S Tomita, SF Traynelis, SF Traynelis, SJ Liu, SM Gardner, SN Kudoh, SQJ Liu, Stuart G Cull-Candy, V Gallo, V Gangadharan, VA Letts, Y Shi, Y Shi   +59 more
core   +1 more source

Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy [PDF]

Science, 2016
Stargazin and the AMPA receptor AMPA-subtype ionotropic glutamate receptors (AMPARs) mediate fast excitatory neurotransmission and contribute to higher cognitive processes such as learning and memory. In the brain, AMPARs exist as protein-protein complexes with various auxiliary subunits that tightly control AMPAR trafficking ...
Edward C, Twomey, Maria V, Yelshanskaya, Robert A, Grassucci, Joachim, Frank, Alexander I, Sobolevsky   +4 more
openaire   +2 more sources

Auxiliary subunits keep AMPA receptors compact during activation and desensitization

eLife, 2018
Signal transduction at vertebrate excitatory synapses involves the rapid activation of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionate) receptors, glutamate-gated ion channels whose four subunits assemble as a dimer-of-dimers.
Jelena Baranovic, Andrew JR Plested
doaj   +1 more source

TARP γ-2 is required for inflammation-associated AMPA receptor plasticity within lamina II of the spinal cord dorsal horn [PDF]

, 2017
In the brain, transmembrane AMPA receptor (AMPAR) regulatory proteins (TARPs) critically influence the distribution, gating, and pharmacology of AMPARs, but the contribution of these auxiliary subunits to AMPAR-mediated signaling in the spinal cord ...
Cull-Candy, SG, Farrant, M, Sullivan, SJ
core   +1 more source

Bidirectional Synaptic Plasticity Regulated by Phosphorylation of Stargazin-like TARPs [PDF]

Neuron, 2005
Synaptic plasticity involves protein phosphorylation cascades that alter the density of AMPA-type glutamate receptors at excitatory synapses; however, the crucial phosphorylated substrates remain uncertain. Here, we show that the AMPA receptor-associated protein stargazin is quantitatively phosphorylated and that stargazin phosphorylation promotes ...
Tomita, Susumu, Stein, Valentin, Stocker, Tim J., Nicoll, Roger A., Bredt, David S.   +4 more
openaire   +2 more sources

LGI1 downregulation increases neuronal circuit excitability

Epilepsia, Volume 61, Issue 12, Page 2836-2846, December 2020., 2020
Abstract Objective Leucine‐rich glioma‐inactivated 1 (LGI1) is a secreted transsynaptic protein that interacts presynaptically with Kv1.1 potassium channels and a disintegrin and metalloprotease (ADAM) protein 23, and postsynaptically influences α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionate receptors through a direct link with the ADAM22 cell ...
Eleonora Lugarà, Rahul Kaushik, Marco Leite, Elodie Chabrol, Alexander Dityatev, Gabriele Lignani, Matthew C. Walker   +6 more
wiley   +1 more source