Results 41 to 50 of about 2,711 (196)
The Journal of Physiology, Volume 600, Issue 2, Page 201-215, 15 January 2022., 2022 Abstract figure legend Retinogeniculate synapses of the dLGN are large synapses with multiple release sites. Pronounced short‐term depression of currents in retinogeniculate synapses results from high release probability and desensitization of AMPA receptors.
Jakob von Engelhardt
wiley +1 more source
Phenotypic heterogeneity in the stargazin allelic series [PDF]
Mammalian Genome, 2003 The stargazer mutant mouse is characterized by its ataxic gait, head tossing, and absence seizures. The mutation was identified in the gamma 2 subunit gene of the high voltage-dependent calcium channel, Cacng2. Subsequently, two allelic variants of stargazer have arisen, waggler and stargazer 3J. In this study, we have compared these new alleles to the
Letts, V A +6 more
openaire +4 more sources
Structural properties and peptide ligand binding of the capsid homology domains of human Arc
Biochemistry and Biophysics Reports, 2021 The activity-regulated cytoskeleton-associated protein (Arc) is important for synaptic plasticity and the normal function of the brain. Arc interacts with neuronal postsynaptic proteins, but the mechanistic details of its function have not been fully ...
Erik I. Hallin +2 more
doaj +1 more source
Journal of Cellular and Molecular Medicine, Volume 25, Issue 15, Page 7418-7425, August 2021., 2021 Abstract We previously showed a hydroxamic acid‐based histone deacetylase inhibitor (HDACi), compound 13, provides neuroprotection against chronic cerebral hypoperfusion (CCH) both in vitro under oxygen‐glucose deprivation (OGD) conditions and in vivo under bilateral common carotid artery occlusion (BCCAO) conditions.
Yao‐Ching Fang +7 more
wiley +1 more source
Ca2+‐permeable AMPA receptors and their auxiliary subunits in synaptic plasticity and disease
The Journal of Physiology, Volume 599, Issue 10, Page 2655-2671, 15 May 2021., 2021 Abstract figure legend AMPARs containing GluA2 (red subunits) are Ca2+‐impermeable (CI‐AMPARs). Those that lack GluA2 are Ca2+‐permeable (CP‐AMPARs) and are implicated in diverse forms of synaptic plasticity and disease. Both native CP‐ and CI‐AMPARs contain various auxiliary subunits (shown as yellow, green or turquoise) that affect AMPAR function and
Stuart G. Cull‐Candy, Mark Farrant
wiley +1 more source
Aging Cell, Volume 20, Issue 4, April 2021., 2021 Ageing reduces the number of OPCs and their ‘stemness’. Genomic analysis resolved key mechanisms underpinning the age related decline in OPCs, most notably reduced expression of Gpr17 in a subpopulation of differentiation committed OPCs. Pharmacogenomics identified small molecules that have the potential to rejuvenate OPCs and promote myelination and ...
Andrea D. Rivera +6 more
wiley +1 more source
Neural Plasticity, Volume 2021, Issue 1, 2021., 2021 Synaptic activity mediates information storage and memory consolidation in the brain and requires a fast de novo synthesis of mRNAs in the nucleus and proteins in synapses. Intracellular localization of a protein can be achieved by mRNA trafficking and localized translation. Activity‐regulated cytoskeleton‐associated protein (Arc) is a master regulator
Michal Fila +5 more
wiley +1 more source
High-affinity anti-Arc nanobodies provide tools for structural and functional studies
PLoS ONE, 2022 Activity-regulated cytoskeleton-associated protein (Arc) is a multidomain protein of retroviral origin with a vital role in the regulation of synaptic plasticity and memory formation in mammals.
Sigurbjörn Markússon +9 more
doaj +3 more sources
Calpain-mediated regulation of stargazin in adult rat brain [PDF]
Neuroscience, 2011 Changes in AMPA receptors have been proposed to underlie changes in synaptic efficacy in hippocampus and other brain structures. Calpain activation has also been discussed as a potential mechanism to produce lasting modifications of synaptic structure and function.
Yi Wang +5 more
openaire +3 more sources
iScience, 2022 Summary: The organization of the postsynaptic density (PSD), a protein-dense semi-membraneless organelle, is mediated by numerous specific protein–protein interactions (PPIs) which constitute a functional postsynapse.
Nikolaj Riis Christensen +9 more
doaj +1 more source