Results 61 to 70 of about 1,621 (161)
Ca2+‐permeable AMPA receptors and their auxiliary subunits in synaptic plasticity and disease
The Journal of Physiology, Volume 599, Issue 10, Page 2655-2671, 15 May 2021., 2021 Abstract figure legend AMPARs containing GluA2 (red subunits) are Ca2+‐impermeable (CI‐AMPARs). Those that lack GluA2 are Ca2+‐permeable (CP‐AMPARs) and are implicated in diverse forms of synaptic plasticity and disease. Both native CP‐ and CI‐AMPARs contain various auxiliary subunits (shown as yellow, green or turquoise) that affect AMPAR function and
Stuart G. Cull‐Candy, Mark Farrant
wiley +1 more source
iScience, 2022 Summary: The organization of the postsynaptic density (PSD), a protein-dense semi-membraneless organelle, is mediated by numerous specific protein–protein interactions (PPIs) which constitute a functional postsynapse.
Nikolaj Riis Christensen +9 more
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Aging Cell, Volume 20, Issue 4, April 2021., 2021 Ageing reduces the number of OPCs and their ‘stemness’. Genomic analysis resolved key mechanisms underpinning the age related decline in OPCs, most notably reduced expression of Gpr17 in a subpopulation of differentiation committed OPCs. Pharmacogenomics identified small molecules that have the potential to rejuvenate OPCs and promote myelination and ...
Andrea D. Rivera +6 more
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Neural Plasticity, Volume 2021, Issue 1, 2021., 2021 Synaptic activity mediates information storage and memory consolidation in the brain and requires a fast de novo synthesis of mRNAs in the nucleus and proteins in synapses. Intracellular localization of a protein can be achieved by mRNA trafficking and localized translation. Activity‐regulated cytoskeleton‐associated protein (Arc) is a master regulator
Michal Fila +5 more
wiley +1 more source
Calpain-mediated regulation of stargazin in adult rat brain [PDF]
Neuroscience, 2011 Changes in AMPA receptors have been proposed to underlie changes in synaptic efficacy in hippocampus and other brain structures. Calpain activation has also been discussed as a potential mechanism to produce lasting modifications of synaptic structure and function.
L, Yu +5 more
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Screening for AMPA receptor auxiliary subunit specific modulators. [PDF]
PLoS ONE, 2017 AMPA receptors (AMPAR) are ligand gated ion channels critical for synaptic transmission and plasticity. Their dysfunction is implicated in a variety of psychiatric and neurological diseases ranging from major depressive disorder to amyotrophic lateral ...
Caleigh M Azumaya +6 more
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Cells, 2022 The AMPA glutamate receptor (AMPAR) is the major type of synaptic excitatory ionotropic receptor in the brain. AMPARs have four different subunits, GluA1–4 (each encoded by different genes, Gria1, Gria2, Gria3 and Gria4), that can form distinct ...
Sophie J. F. van der Spek +7 more
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Mechanism of Modulation of AMPA Receptors by Stargazin [PDF]
Biophysical Journal, 2014 AMPA receptors (AMPARs) mediate most of the fast excitatory synaptic transmission in the brain. Native AMPARs typically form heterotetrameric complexes and associate with a variety of auxiliary subunits. Stargazin (gamma2) is the prototype and most studied member of the transmembrane AMPA receptor regulatory proteins family, and regulates several ...
Carbone, Anna L., Plested, Andrew J.
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Frontiers in Molecular Neuroscience, 2017 Feedforward inhibition is essential to prevent run away excitation within the brain. Recent evidence suggests that a loss of feed-forward inhibition in the corticothalamocortical circuitry may underlie some absence seizures.
Nadia K. Adotevi, Beulah Leitch
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