Results 61 to 70 of about 2,576 (168)

Dual Effects of TARP γ-2 on Glutamate Efficacy Can Account for AMPA Receptor Autoinactivation [PDF]

, 2017
Fast excitatory transmission in the CNS is mediated mainly by AMPA-type glutamate receptors (AMPARs) associated with transmembrane AMPAR regulatory proteins (TARPs).
Coombs, ID, Cull-Candy, SG, Farrant, M, Jayaraman, V, MacLean, DM   +4 more
core   +2 more sources

Slow AMPAR Synaptic Transmission Is Determined by Stargazin and Glutamate Transporters [PDF]

Neuron, 2017
AMPARs mediate the briefest synaptic currents in the brain by virtue of their rapid gating kinetics. However, at the mossy fiber-to-unipolar brush cell synapse in the cerebellum, AMPAR-mediated EPSCs last for hundreds of milliseconds, and it has been proposed that this time course reflects slow diffusion from a complex synaptic space. We show that upon
Hsin-Wei, Lu, Timothy S, Balmer, Gabriel E, Romero, Laurence O, Trussell   +3 more
openaire   +2 more sources

PSD95 Suppresses Dendritic Arbor Development in Mature Hippocampal Neurons by Occluding the Clustering of NR2B-NMDA Receptors [PDF]

, 2013
Considerable evidence indicates that the NMDA receptor (NMDAR) subunits NR2A and NR2B are critical mediators of synaptic plasticity and dendritogenesis; however, how they differentially regulate these processes is unclear.
Aguayo, Luis G., Bustos, Fernando J., Campos, Matias, Constantine-Paton, Martha, Henriquez, Berta, Inestrosa, Nibaldo C., Montecino, Martin, Opazo, Carlos, Phillips, Marnie, Phillips, Marnie, van Zundert, Brigitte, Varela-Nallar, Lorena   +11 more
core   +13 more sources

The regulation of dendritic arbor development and plasticity by glutamatergic synaptic input: a review of the synaptotrophic hypothesis [PDF]

, 2008
: The synaptotropic hypothesis, which states that synaptic inputs control the elaboration of dendritic (and axonal) arbors was articulated by Vaughn in 1989. Today the role of synaptic inputs in controlling neuronal structural development remains an area
Hollis Cline, Kurt Haas, Aizenman, Bamji, Bats, Bellone, Cantallops, Cantallops, Carmignoto, Chen, Cho, Chubykin, Cline, Dalva, Durand, Eybalin, Feldheim, Flavell, Futai, Ghosh, Haas, Hestrin, Ho, Hua, Hua, Isaac, Konur, Kumar, Liao, Migues, Milstein, Moore, Nedivi, Niell, O'Leary, Osten, Polleux, Portera-Cailliau, Rajan, Rajan, Rumpel, Ruthazer, Sahay, Sanchez, Scheiffele, Sheng, Shi, Sin, Snider, Takahashi, Thomas, Tomita, Vaughn, Vaughn, Vaughn, Verhage, Wong, Wong, Wu, Wu, Wu, Yamagata, Ye, Zhu, Ziv, Ziv   +65 more
core   +1 more source

Global Scaling Down of Excitatory Postsynaptic Responses in Cerebellar Purkinje Cells Impairs Developmental Synapse Elimination

Cell Reports, 2014
Synapse elimination is crucial for precise neural circuit formation during postnatal development. We examined how relative differences in synaptic strengths among competing inputs and/or absolute synaptic strengths contribute to climbing fiber (CF) to ...
Shinya Kawata, Taisuke Miyazaki, Maya Yamazaki, Takayasu Mikuni, Miwako Yamasaki, Kouichi Hashimoto, Masahiko Watanabe, Kenji Sakimura, Masanobu Kano   +8 more
doaj   +1 more source

Human neuronal stargazin-like proteins, gamma(2), gamma(3) and gamma(4); an investigation of their specific localization in human brain and their influence on Ca(V)2.1 voltage-dependent calcium channels expressed in Xenopus oocytes [PDF]

, 2003
Background: Stargazin (gamma(2)) and the closely related gamma(3), and gamma(4) transmembrane proteins are part of a family of proteins that may act as both neuronal voltage-dependent calcium channel (VDCC) gamma subunits and transmembrane alpha-amino-3 ...
Clare, JJ, Dolphin, AC, Moss, FJ
core  

Gain of function mutants: Ion channels and G protein-coupled receptors [PDF]

, 2000
Many ion channels and receptors display striking phenotypes for gain-of-function mutations but milder phenotypes for null mutations. Gain of molecular function can have several mechanistic bases: selectivity changes, gating changes including constitutive
Karschin, Andreas, Lester, Henry A.
core   +1 more source

The Stargazin-Related Protein {gamma}7 Interacts with the mRNA-Binding Protein Heterogeneous Nuclear Ribonucleoprotein A2 and Regulates the Stability of Specific mRNAs, Including CaV2.2 [PDF]

, 2008
The role(s) of the novel stargazin-like {gamma}-subunit proteins remain controversial. We have shown previously that the neuron-specific {gamma}7 suppresses the expression of certain calcium channels, particularly CaV2.2, and is therefore unlikely to ...
Bolsover, Steven, Butcher, Adrian J., Cox, David J., Davies, Anthony, Dolphin, Annette C., Ferron, Laurent, Leroy, Jerôme, Moss, Fraser J., Page, Karen M., Pratt, Wendy S., Sellaturay, Priya, Waithe, Dominic   +11 more
core   +1 more source

Long-term potentiation in bone – a role for glutamate in strain-induced cellular memory? [PDF]

, 2003
Background The adaptive response of bone cells to mechanical strain is a primary determinant of skeletal architecture and bone mass. In vivo mechanical loading induces new bone formation and increases bone mineral density whereas disuse, immobilisation ...
Genever Paul G, Spencer Gary J
core   +1 more source

Further characterization of regulation of Ca_V2.2 by Stargazin [PDF]

Channels, 2010
Stargazin, a transmembrane protein expressed in the nervous system, shares similarities with the γ₁ subunit of skeletal muscle calcium channels. It was thus termed γ₂ subunit of neuronal calcium channels. Stargazin downregulates the expression of Ca(V)2 channels, however, its functional modulation of these channels remains debated.
Isabella, Tselnicker, Nathan, Dascal
openaire   +2 more sources