Results 61 to 70 of about 2,711 (196)

Stargazin promotes closure of the AMPA receptor ligand-binding domain [PDF]

Journal of General Physiology, 2014
Transmembrane AMPA receptor (AMPAR) regulatory proteins (TARPs) markedly enhance AMPAR function, altering ligand efficacy and receptor gating kinetics and thereby shaping the postsynaptic response. The structural mechanism underlying TARP effects on gating, however, is unknown.
Mei-mei Du, David M. MacLean, Vasanthi Jayaraman, Swarna S. Ramaswamy, James R. Howe   +4 more
openaire   +2 more sources

Aggregation Limits Surface Expression of Homomeric GluA3 Receptors [PDF]

, 2016
AMPA receptors are glutamate-gated cation channels assembled from GluA1-4 subunits and have properties that are strongly dependent on the subunit composition.
Ahmed, Armstrong, Artur Semenov, Balasuriya, Cai, Coleman, Coleman, Coleman, Coleman, Cull-Candy, Gan, Gill, Gill, Greger, Greger, Greger, Grunwald, Isaac, Kari Keinänen, Kim, Kuusinen, Lu, Mah, Mansour, Marina Willibald, Mayer, Möykkynen, Nakagawa, Palmer, Pasternack, Pei, Penn, Rossmann, Sarah K. Coleman, Shanks, Sobolevsky, Sukumaran, Tommi Möykkynen, Traynelis, Valluru, Vandenberghe, Vandenberghe, Wenthold, Ying Hou, Zhao   +44 more
core   +1 more source

Auxiliary subunits keep AMPA receptors compact during activation and desensitization

eLife, 2018
Signal transduction at vertebrate excitatory synapses involves the rapid activation of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionate) receptors, glutamate-gated ion channels whose four subunits assemble as a dimer-of-dimers.
Jelena Baranovic, Andrew JR Plested
doaj   +1 more source

Paradoxical proepileptic response to NMDA receptor blockade linked to cortical interneuron defect in stargazer mice

Frontiers in Cellular Neuroscience, 2013
Paradoxical seizure exacerbation by antiepileptic medication is a well-known clinical phenomenon in epilepsy, but the cellular mechanisms remain unclear.
Atul eMaheshwari, Walter eNahm, Jeffrey eNoebels   +2 more
doaj   +1 more source

AMPA Receptor Trafficking and the Control of Synaptic Transmission [PDF]

, 2001
Modificacions aprovades pel Plenari del Consell Municipal el 28-01 ...
Ajuntament de Barcelona, Gerència de Promoció Econòmica, Oficina de Management i Pressupost Executiu   +2 more
core   +1 more source

Glutamatergic Reinnervation and Assembly of Glutamatergic Synapses in Adult Rat Skeletal Muscle Occurs at Cholinergic Endplates [PDF]

, 2009
After denervation of adult rat abdominal muscles, the postsynaptic apparatus of neuromuscular junctions (NMJs) retains its original architecture and clustering of acetylcholine receptors (AChRs).
A. BARBON, BAIGUERA C, BARLATI S, BORONI F, BRUNELLI G, BUFFELLI M, CAMBIANICA I, CLEMENTI F, ETTORRE M, FRANCOLINI M, GUARNERI B, LA VIA L, LANZILLOTTA A, PIZZI M, SPANO PF   +14 more
core   +1 more source

Glutamatergic neurons induce expression of functional glutamatergic synapses in primary myotubes. [PDF]

, 2012
The functioning of the nervous system depends upon the specificity of its synaptic contacts. The mechanisms triggering the expression of the appropriate receptors on postsynaptic membrane and the role of the presynaptic partner in the differentiation of ...
Baiguera C, Benarese M, Branca C, Buffelli M, Ettorre M, Laperchia C, Lorenzetto E, Pizzi M, Spano P   +8 more
core   +1 more source

Auxiliary Subunit GSG1L Acts to Suppress Calcium-Permeable AMPA Receptor Function [PDF]

, 2015
UNLABELLED: AMPA-type glutamate receptors are ligand-gated cation channels responsible for a majority of the fast excitatory synaptic transmission in the brain.
Bats, C, Cull-Candy, SG, Farrant, M, McGee, TP   +3 more
core   +2 more sources

PSD95 Suppresses Dendritic Arbor Development in Mature Hippocampal Neurons by Occluding the Clustering of NR2B-NMDA Receptors [PDF]

, 2013
Considerable evidence indicates that the NMDA receptor (NMDAR) subunits NR2A and NR2B are critical mediators of synaptic plasticity and dendritogenesis; however, how they differentially regulate these processes is unclear.
Aguayo, Luis G., Bustos, Fernando J., Campos, Matias, Constantine-Paton, Martha, Henriquez, Berta, Inestrosa, Nibaldo C., Montecino, Martin, Opazo, Carlos, Phillips, Marnie, Phillips, Marnie, van Zundert, Brigitte, Varela-Nallar, Lorena   +11 more
core   +13 more sources

Gain of function mutants: Ion channels and G protein-coupled receptors [PDF]

, 2000
Many ion channels and receptors display striking phenotypes for gain-of-function mutations but milder phenotypes for null mutations. Gain of molecular function can have several mechanistic bases: selectivity changes, gating changes including constitutive
Karschin, Andreas, Lester, Henry A.
core   +1 more source