Results 61 to 70 of about 1,323 (153)

Global Scaling Down of Excitatory Postsynaptic Responses in Cerebellar Purkinje Cells Impairs Developmental Synapse Elimination

Cell Reports, 2014
Synapse elimination is crucial for precise neural circuit formation during postnatal development. We examined how relative differences in synaptic strengths among competing inputs and/or absolute synaptic strengths contribute to climbing fiber (CF) to ...
Shinya Kawata, Taisuke Miyazaki, Maya Yamazaki, Takayasu Mikuni, Miwako Yamasaki, Kouichi Hashimoto, Masahiko Watanabe, Kenji Sakimura, Masanobu Kano   +8 more
doaj   +1 more source

Phosphorylation‐regulated phase separation of syndecan‐4 and syntenin promotes the biogenesis of exosomes

Cell Proliferation, Volume 57, Issue 10, October 2024.
This research uncovers a novel phosphorylation‐regulated phase separation property of SDC4 on the PM by which SDC4 realizes efficient recruitment of cytosolic syntenin and thereby facilitates the biogenesis of exosomes, providing potential intervention targets for exosome‐involved biomedical events. Abstract The biogenesis of exosomes that mediate cell‐
Tian Zhao, Xiaolan Yang, Guangfei Duan, Jialin Chen, Kefeng He, Yong‐Xiang Chen, Shi‐Zhong Luo   +6 more
wiley   +1 more source

Emerging Synaptic Molecules as Candidates in the Etiology of Neurological Disorders

Neural Plasticity, Volume 2017, Issue 1, 2017., 2017
Synapses are complex structures that allow communication between neurons in the central nervous system. Studies conducted in vertebrate and invertebrate models have contributed to the knowledge of the function of synaptic proteins. The functional synapse requires numerous protein complexes with specialized functions that are regulated in space and time
Viviana I. Torres, Daniela Vallejo, Nibaldo C. Inestrosa, Tiziana Borsello   +3 more
wiley   +1 more source

Identification of immune infiltration and PANoptosis‐related molecular clusters and predictive model in Alzheimer's disease based on transcriptome analysis

Ibrain, Volume 10, Issue 3, Page 323-344, Fall 2024.
Based on R, immune infiltration analysis found that normal and disease immune cells expressed differently, weighted gene co‐expression network analysis determined the key genes of diseases and clustering, and eXtreme Gradient Boosting model screened Hub genes. Abstract This study aims to explore the expression profile of PANoptosis‐related genes (PRGs)
Jin‐Lin Mei, Shi‐Feng Wang, Yang‐Yang Zhao, Ting Xu, Yong Luo, Liu‐Lin Xiong   +5 more
wiley   +1 more source

Amyloid‐β‐Induced Dysregulation of AMPA Receptor Trafficking

Neural Plasticity, Volume 2016, Issue 1, 2016., 2016
Evidence from neuropathological, genetic, animal model, and biochemical studies has indicated that the accumulation of amyloid‐beta (Aβ) is associated with, and probably induces, profound neuronal changes in brain regions critical for memory and cognition in the development of Alzheimer’s disease (AD).
Sumasri Guntupalli, Jocelyn Widagdo, Victor Anggono, Long-Jun Wu   +3 more
wiley   +1 more source

Nitric Oxide‐Mediated Posttranslational Modifications: Impacts at the Synapse

Oxidative Medicine and Cellular Longevity, Volume 2016, Issue 1, 2016., 2016
Nitric oxide (NO) is an important gasotransmitter molecule that is involved in numerous physiological processes throughout the nervous system. In addition to its involvement in physiological plasticity processes (long‐term potentiation, LTP; long‐term depression, LTD) which can include NMDAR‐mediated calcium‐dependent activation of neuronal nitric ...
Sophie A. Bradley, Joern R. Steinert, Vittorio Calabrese   +2 more
wiley   +1 more source

Transmembrane α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor regulatory protein expression during the development of absence seizures in genetic absence epilepsy rats from Strasbourg

Epilepsia, Volume 65, Issue 2, Page e20-e26, February 2024.
Abstract The transmembrane α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor (AMPAR) regulatory proteins (TARPs), γ2 (stargazin), γ3, γ4, γ5, γ7, and γ8, are a family of proteins that regulate AMPAR trafficking, expression, and biophysical properties that could have a role in the development of absence seizures.
Pablo M. Casillas‐Espinosa, Runxuan Lin, Rui Li, Kim L. Powell, Terence J. O'Brien   +4 more
wiley   +1 more source

D‐Amino Acids in the Nervous and Endocrine Systems

Scientifica, Volume 2016, Issue 1, 2016., 2016
Amino acids are important components for peptides and proteins and act as signal transmitters. Only L‐amino acids have been considered necessary in mammals, including humans. However, diverse D‐amino acids, such as D‐serine, D‐aspartate, D‐alanine, and D‐cysteine, are found in mammals.
Yoshimitsu Kiriyama, Hiromi Nochi, Mirko Diksic   +2 more
wiley   +1 more source

Bidirectional protein–protein interactions control liquid–liquid phase separation of PSD-95 and its interaction partners

iScience, 2022
Summary: The organization of the postsynaptic density (PSD), a protein-dense semi-membraneless organelle, is mediated by numerous specific protein–protein interactions (PPIs) which constitute a functional postsynapse.
Nikolaj Riis Christensen, Christian Parsbæk Pedersen, Vita Sereikaite, Jannik Nedergaard Pedersen, Maria Vistrup-Parry, Andreas Toft Sørensen, Daniel Otzen, Kaare Teilum, Kenneth Lindegaard Madsen, Kristian Strømgaard   +9 more
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Stargazin and AMPA receptor membrane expression is increased in the somatosensory cortex of Genetic Absence Epilepsy Rats from Strasbourg

Neurobiology of Disease, 2011
Absence-like seizures in the Genetic Absence Epilepsy Rats from Strasbourg (GAERS) model are believed to arise in hyperexcitable somatosensory cortical neurons, however the cellular basis of this increased excitability remains unknown. We have previously
J.T.T. Kennard, R. Barmanray, S. Sampurno, E. Ozturk, C.A. Reid, L. Paradiso, G.M. D'Abaco, A.H. Kaye, S.J. Foote, T.J. O'Brien, K.L. Powell   +10 more
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