Results 161 to 170 of about 179,101 (246)

Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source

Gastrin ameliorates heart failure and suppresses myocardial remodeling via the JAK2/STAT3 and ERK1/2 pathways. [PDF]

PLoS One
Du Y, Wang N, Dong J, Chai X, Liu L, Zhang H, Li B, Yang J.   +7 more
europepmc   +1 more source

Single‐Cell RNA Sequencing Informs Precision Targeting of Monogenic Lupus Associated With IKZF1 Haploinsufficiency

Arthritis &Rheumatology, EarlyView.
Objective This study aimed to investigate the mechanisms of immune dysregulation in a pediatric patient with monogenic lupus driven by IKZF1 haploinsufficiency. Methods Peripheral immune cells from a patient with IKZF1 haploinsufficiency, patients with lupus with no currently known genetic mutations, and healthy controls were analyzed using single‐cell
Qi Zheng, Yejun Tan, Zhaoling Wang, Yanjie Qian, Qian Ma, Danping Shen, Meiping Lu   +6 more
wiley   +1 more source

Activation of M1mAChR's improves spatial learning and memory deficits in rats exposed to chronic intermittent hypoxia. [PDF]

Sci Rep
Huang Q, Hu C, Liu H, Liu C, Liu X, Xu Z, Xu P.   +6 more
europepmc   +1 more source

The Effect of Intranasal Niclosamide on Nasal Symptoms in Patients with Antineutrophil Cytoplasmic Antibody–Associated Vasculitis

Arthritis &Rheumatology, EarlyView.
Objective Ear, nose, and throat (ENT) manifestations are common in antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV). There is an unmet need for drugs to target these manifestations. Granuloma formation is characteristic of proteinase 3 (PR3)–AAV. In a zebrafish model, niclosamide inhibits PR3‐induced granuloma formation.
Benjamin Lim, Wendi Qian, Francis Dowling, Alan Salama, Rona M Smith   +4 more
wiley   +1 more source

Signal transducer and activator of transcription 3β in pancreatic cancer

Open Life Sciences, 2010
Dettlaff-Pokora Agnieszka, Kostro Justyna   +1 more
doaj   +1 more source

Phosphorylated-STAT3 Y705 [PDF]

, 2020
openaire   +1 more source

Serum Proteomic Signatures of Rheumatoid Arthritis Risk and Response: Analysis of a Rheumatoid Arthritis Interception Trial

Arthritis &Rheumatology, EarlyView.
Objective Our study objective was to identify serum protein signatures associated with progression to rheumatoid arthritis (RA) and response to abatacept in at‐risk individuals. Methods A total of 440 serum samples from 118 APIPPRA (Arthritis Prevention In the Preclinical Phase of RA with Abatacept) study participants were selected from baseline to RA ...
Marianna Jasenecova, Carl Coyle, Alina Mihalovits, Sarah Ryan, Elizabeth Pook, Esperanza Perucha, Gabrielle Harker, Melody Chin, Sam Norton, Andrew P. Cope   +9 more
wiley   +1 more source

Long Non‐Coding RNA H19 mediates STAT3 dependent activation of keratinocytes and fibroblasts in Systemic Sclerosis skin

Arthritis &Rheumatology, Accepted Article.
Objective Dermal Systemic Sclerosis (SSc) fibroblasts and their exosomes can activate keratinocytes in SSc, with lncRNA H19 (H19) highlighted as the most upregulated RNA in their cargo compared to healthy control (HC). The role of H19 in SSc pathogenesis has never been investigated.
Begoña Caballero‐Ruiz, Christopher W Wasson, Rebecca L Ross, Francesco Del Galdo   +3 more
wiley   +1 more source

ω-3 PUFAs Attenuate Postoperative Ileus by Modulating Macrophage Polarization via the JAK2/STAT3 Signaling Pathway. [PDF]

J Inflamm Res
Zhao X, Yu J, Zhang T, Zhang Y, Zhang L, Wang Y, Yi C, Pan H, Wang H, Ge M, Jiang Z, Wang G.   +11 more
europepmc   +1 more source