Results 161 to 170 of about 250,824 (344)

ZFAS1/STAT3 axis modulates imatinib resistance of chronic myeloid leukemia cells through glucose metabolism reprogramming

Frontiers in Oncology
BackgroundChronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by the presence of the Philadelphia chromosome (chromosome 22). This cytogenetic abnormality gives rise to the BCR::ABL1 fusion gene, which encodes the constitutively
Lan Yang, Yanqiu Han
doaj   +1 more source

Murine Oncostatin M Acts via Leukemia Inhibitory Factor Receptor to Phosphorylate Signal Transducer and Activator of Transcription 3 (STAT3) but Not STAT1, an Effect That Protects Bone Mass [PDF]

, 2016
Emma C. Walker, Rachelle W. Johnson, Yifang Hu, Holly J. Brennan, Ingrid J. Poulton, Jian‐Guo Zhang, Brendan J. Jenkins, Gordon K. Smyth, Nicos A. Nicola, Natalie A. Sims   +9 more
openalex   +1 more source

DNA‐Inspired Multi‐Functional Double‐Cross‐Linking Self‐Healing Hydrogel Promotes the Healing of Diabetic Wounds

Advanced Science, EarlyView.
A self‐healing hydrogel crosslinked with dynamic nucleobase‐mimetic bonds delivers curcumin‐loaded exosomes. It promotes diabetic wound healing via a synergistic combination of antibacterial, anti‐inflammatory, pro‐angiogenic, and immunomodulatory mechanisms, providing a comprehensive therapeutic approach.
Pu Yang, Yue Hu, Yikun Ju, Naihsin Hsiung, Juyi Ye, Anquan Jian, Lanjie Lei, Bairong Fang   +7 more
wiley   +1 more source

Interleukin-11 induces the expression of matrix metalloproteinase 13 in gastric cancer SCH cells partly through PI3K-AKT and JAK-STAT3 pathways

, 2015
Gong‐Li Yang, Feng Ma, Muxiao Zhong, Lin Fang, Yao Peng, Xiaoming Xin, Jietao Zhong, Wei Zhu, Yali Zhang   +8 more
openalex   +2 more sources

Population‐Based Multi‐Omics and Cohort Study Identifying Predictive Biomarkers and Therapeutic Targets for Psoriatic Disease

Advanced Science, EarlyView.
Psoriatic disease (PsD) is a chronic skin disease, with challenges in early risk stratification and drug development. Through gene‐level causal inference framework and expression level validation, combined with longitudinal cohort study, CDSN and PRSS8 have been identified as candidate biomarkers and therapeutic targets for PsD.
Tianxing Wu, Jialiang Luo, Haoyuan Qiu, Weijie Shao, Yueyang Lu, Meixuan Luo, Zhaofeng Lin, Yan Zhang, Libo Zhang, Hong Wang, Jia Zhou, Guangfeng Ruan, Peihua Cao, Daming Zuo   +13 more
wiley   +1 more source

Editorial: Chemokine receptors and signaling in wound healing

Frontiers in Pharmacology, 2023
Zhenlong Chen, Richard D. Minshall
doaj   +1 more source

Phosphorylated STAT3 to STAT3 Ratio Measurement [PDF]

, 2020
openaire   +1 more source

Santamarine Inhibits NF-кB and STAT3 Activation and Induces Apoptosis in HepG2 Liver Cancer Cells via Oxidative Stress. [PDF]

, 2017
Tahir Mehmood, Amara Maryam, Xiangge Tian, Muhammad Noman Khan, Tonghui Ma   +4 more
openalex   +1 more source

Magnolol Induces the Extrinsic/Intrinsic Apoptosis Pathways and Inhibits STAT3 Signaling-Mediated Invasion of Glioblastoma Cells [PDF]

, 2021
Po‐Fu Yueh, Yuan‐Hao Lee, FU Chun-yu, Chun-Bin Tung, Fei‐Ting Hsu, Keng‐Hsin Lan   +5 more
openalex   +1 more source

PDIA3 Inhibition Facilitates Sensitivity of IKE‐Induced Ferroptosis via STAT3/LCN2 Axis to Improve Glioblastoma Therapy

Advanced Science, EarlyView.
In this manuscript, protein disulfide isomerase A3 (PDIA3) is identified as a key factor mediating the susceptibility of ferroptosis in GBM. Inhibition of PDIA3 enhances IKE or cystine starvation‐induced ferroptosis in GBM cells by resulting in the accumulation of lipid peroxidation and a reduction in GSH level.
Jie Zhang, Wei Wang, Xin Liu, Peifen Lu, Xinjing Liu, Qiucheng Nie, Siyuan Xin, Hong Li, Donglin Yu, Xinyue Zhang, Kailong Li, Xiaomin Han, Shuping Zhang, Wei Chong, Lili Sun, Wei Li, Tao Xin, Jin Jiao, Qiang Ma, Yiju Wei   +19 more
wiley   +1 more source