Results 271 to 280 of about 196,678 (325)

IL-6/GP130/JAK/STAT3 Pathway Activation in Pancreatic Ductal Adenocarcinoma and Its Association With Clinical Features: Protocol for a Retrospective Cross-Sectional Study.

JMIR Res Protoc
Mellenthin C, Schaller F, Vignot L, Peisl S, Vesce R, Esposito I, Gonelle-Gispert C, Schneider C, Adamina M, Bühler LH.   +9 more
europepmc   +1 more source

Treg Cells Impair Talaromyces Marneffei Clearance by Promoting M2 Macrophage Polarization Via the IL-10/IL-10R/STAT3 Axis. [PDF]

Inflammation
Tang M, Wen Z, Xin F, Fang G, Tang S, Zhang H, Qiu Y, Zhang J.   +7 more
europepmc   +1 more source

PO-237 The pro-oncogenic transcription factor STAT3 regulates Ca2 +release and apoptosis from the endoplasmic reticulum via interaction with the Ca2 +CHANNEL IP3R3

, 2018
Lidia Avalle, Annalisa Camporeale, Giampaolo Morciano, Elena Ghetti, Valeria Orecchia, Carlotta Giorgi, Paolo Pinton, Valeria Poli   +7 more
openalex   +1 more source

Systematic identification of single transcription factor perturbations that drive cellular and tissue rejuvenation. [PDF]

Proc Natl Acad Sci U S A
Sengstack J, Zheng J, Aghayev T, Bieri G, Mobaraki M, Lin J, Deng C, Villeda SA, Li H.   +8 more
europepmc   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Very-early-onset autoimmune hypothyroidism: a report of two cases with STAT3 gain-of-function variant. [PDF]

Eur Thyroid J
Ravi R, Niskanen A, Reeve MP, Makkonen K, Niinikoski H, Toppari J, Kero J.   +6 more
europepmc   +1 more source

Potential neuroprotective and therapeutic agents and their mechanisms for irradiation‐induced brain injury

Ibrain, EarlyView.
In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard, Vivian Kapio Abem, Sagor Kumar Roy   +2 more
wiley   +1 more source

Trans-Omic Analysis Identifies the 'PRMT1-STAT3-Integrin αVβ6 Axis' as a Novel Therapeutic Target in Tacrolimus-Induced Chronic Nephrotoxicity. [PDF]

Int J Mol Sci
Nishida S, Ishima T, Iwami D, Nagai R, Aizawa K.   +4 more
europepmc   +1 more source

HIF2A as a prognostic and clinical therapeutic target in ovarian clear cell carcinoma

International Journal of Cancer, EarlyView.
What's New? Ovarian clear cell carcinoma is highly associated with hypoxia. Hypoxia‐inducible factor 2A (HIF2A) is a key regulator of hypoxic responses, but its role in ovarian clear cell carcinoma remains unclear. This study demonstrated the unfavorable prognostic significance of HIF2A expression in ovarian clear cell carcinoma.
Mengxin Jiang, Ken Yamaguchi, Kohei Hamada, Yuko Hosoe, Yuka Mise, Sachiko Kitamura, Zhihong Liu, Hairong Wei, Zhenhai Gao, Mana Taki, Koji Yamanoi, Ryusuke Murakami, Rin Mizuno, Taito Miyamoto, Junzo Hamanishi, Masaki Mandai   +15 more
wiley   +1 more source

Signaling pathways of marine-derived natural products on lung injury: from the <i>in vivo</i> perspective. [PDF]

Front Pharmacol
Wang H, Qiu F.
europepmc   +1 more source