Results 291 to 300 of about 833,114 (323)

Linezolid/STAT3 transcription factor inhibitor interaction

Reactions Weekly, 2019

semanticscholar   +2 more sources

Cellular dynamics of the STAT3 transcription factor

Cytokine, 2009
V. Cimica, J. Iyer, N. Reich
semanticscholar   +2 more sources

Targeting key transcriptional factor STAT3 in colorectal cancer

Molecular and Cellular Biochemistry, 2021
In developed countries, colorectal cancer (CRC) is the fourth most common cancer and the second leading cause of malignant-related deaths. CRC is treatable cancer when diagnosed early; however, diagnosis at the advanced stage is associated with a poor prognosis. Although chemotherapy is generally very promising, STAT3 protein which is overexpressed and
Gayathri Chalikonda, Hoomin Lee, Aliya Sheik, Yun Suk Huh   +3 more
openaire   +2 more sources

The pleiotropic role of transcription factor STAT3 in oncogenesis and its targeting through natural products for cancer prevention and therapy

Medicinal research reviews (Print), 2020
Signal transducer and activator of transcription 3 (STAT3) is one of the crucial transcription factors, responsible for regulating cellular proliferation, cellular differentiation, migration, programmed cell death, inflammatory response, angiogenesis ...
M. Garg, M. Shanmugam, Vipul Bhardwaj, A. Goel, Rajat M. Gupta, Arundhiti Sharma, P. Baligar, A. Kumar, B. Goh, Lingzhi Wang, G. Sethi   +10 more
semanticscholar   +1 more source

Angiotensin II stimulates rapid serine phosphorylation of transcription factor Stat3

Molecular and Cellular Biochemistry, 1997
In rat neonatal cardiac fibroblasts and CHO-K1 cells expressing angiotensin type 1 receptors, angiotensin II (AII) rapidly caused a time dependent reduction in the SDS-polyacrylamide gel electrophoretic mobility of Stat3 (Signal Transducer and Activator of Transcription).
G J, Bhat, K M, Baker
openaire   +2 more sources

Transcription Factor STAT3 in Leptin Target Neurons of the Rat Hypothalamus

Neuroendocrinology, 1998
Leptin is an adipose tissue-derived hormone that regulates body weight via interactions with hypothalamic neuronal circuitries expressing specific leptin receptors (Ob-R). The Ob-Rs act via the JAK-STAT (Janus kinase-signal transducers and activators of transcription) pathway of signal transduction.
M L, Håkansson, B, Meister
openaire   +2 more sources

The transcription factor STAT3 and aging: an intermediate medium

Biogerontology
Aging is a physiological/pathological process accompanied by progressive impairment of cellular function, leading to a variety of aging-related diseases. STAT3 is one of the core regulatory factors of aging. It is involved in body metabolism, development and senescence, cell apoptosis and so on.
Min, Shi, Honyu, Li, Runyu, Liang, Haiyan, Lin, Qiang, Tang   +4 more
openaire   +2 more sources

STAT3 correlates with stem cell-related transcription factors in cervical cancer

Journal of Huazhong University of Science and Technology [Medical Sciences], 2015
Cancer stem cells (CSCs) are considered responsible for the high recurrence rate in cervical carcinoma. It has been demonstrated that the signal transducer and activator of transcription 3 (STAT3) is involved in the oncogenesis and takes part in mediating the effects of maintaining stem cell phenotype and pluripotency by regulating the expression of ...
Hua, Wang, Hong-Bing, Cai, Lou-Lou, Chen, Wen-Jun, Zhao, Pan, Li, Zhi-Qiang, Wang, Zhen, Li   +6 more
openaire   +2 more sources

Role of the Leukemia-associated Transcription Factor STAT3 in Platelet Physiology

Leukemia & Lymphoma, 2002
Actinomycin D, a transcriptional inhibitor, was found to inhibit platelet potentiation by thrombopoietin (TPO), suggesting that TPO stimulation of platelets involves mitochondrial transcription. We sought to determine a possible role for leukemia-associated signal transducers and activators of transcription (STAT) proteins as mitochondrial ...
Alexei O, Vassilev, David R, Lorenz, Heather E, Tibbles, Fatih M, Uckun   +3 more
openaire   +2 more sources

STAT3 operates as a novel transcription factor that regulates NEDD4 in Keloid

Biochemical and Biophysical Research Communications, 2019
Keloid, marked by excessive deposition of extracellular matrix components, usually occurs after cutaneous trauma. The molecular mechanism involved in the etiology of keloid remains largely unknown in spite of extensive studies presented on the mechanism of Keloid.
Yu, Wang, Bo, Yuan, Liang, Qiao, Huizhong, Yang, Xuechuan, Li   +4 more
openaire   +2 more sources