Results 301 to 310 of about 196,678 (325)

Targeting key transcriptional factor STAT3 in colorectal cancer

Molecular and Cellular Biochemistry, 2021
In developed countries, colorectal cancer (CRC) is the fourth most common cancer and the second leading cause of malignant-related deaths. CRC is treatable cancer when diagnosed early; however, diagnosis at the advanced stage is associated with a poor prognosis. Although chemotherapy is generally very promising, STAT3 protein which is overexpressed and
Gayathri Chalikonda, Hoomin Lee, Aliya Sheik, Yun Suk Huh   +3 more
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Role of STAT3 Transcription Factor in Pathogenesis of Bronchial Asthma

Biochemistry (Moscow), 2021
Bronchial asthma is a heterogeneous chronic inflammatory disease of airways. The studies of molecular and cellular mechanisms of bronchial asthma have established that a wide range of immune (T and B cells, eosinophils, neutrophils, macrophages, etc.) and structural (epithelial and endothelial) cells are involved in its pathogenesis.
Aleksandr A, Nikolskii, Igor P, Shilovskiy, Ekaterina D, Barvinskaia, Artem V, Korneev, Maria S, Sundukova, Musa R, Khaitov   +5 more
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STAT3 transcription factor as target for anti-cancer therapy

Pharmacological Reports, 2020
STATs constitute a large family of transcription activators and transducers of signals that have an important role in many cell functions as regulation of proliferation and differentiation of the cell also regulation of apoptosis and angiogenesis. STAT3 as a member of that family, recently was discovered to have a vital role in progression of different
Aliaa M. Mohassab, Heba A. Hassan, Dalia Abdelhamid, Mohamed Abdel-Aziz   +3 more
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Targeting transcription factor STAT3 for cancer prevention and therapy

Pharmacology & Therapeutics, 2016
Signal Transducers and Activators of Transcription (STATs) comprise an important class of transcription factors that have been implicated in a wide variety of essential cellular functions related to proliferation, survival, and angiogenesis. Among various STAT members, STAT3 is frequently overexpressed in tumor cells as well as tissue samples, and ...
Chai, E., Shanmugam, M., Arfuso, Frank, Dharmarajan, Arunasalam, Wang, C., Kumar, A., Samy, R., Lim, L., Wang, L., Goh, B., Ahn, K., Hui, K., Sethi, G.   +12 more
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Angiotensin II stimulates rapid serine phosphorylation of transcription factor Stat3

Molecular and Cellular Biochemistry, 1997
In rat neonatal cardiac fibroblasts and CHO-K1 cells expressing angiotensin type 1 receptors, angiotensin II (AII) rapidly caused a time dependent reduction in the SDS-polyacrylamide gel electrophoretic mobility of Stat3 (Signal Transducer and Activator of Transcription).
G J, Bhat, K M, Baker
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Transcription Factor STAT3 in Leptin Target Neurons of the Rat Hypothalamus

Neuroendocrinology, 1998
Leptin is an adipose tissue-derived hormone that regulates body weight via interactions with hypothalamic neuronal circuitries expressing specific leptin receptors (Ob-R). The Ob-Rs act via the JAK-STAT (Janus kinase-signal transducers and activators of transcription) pathway of signal transduction.
M L, Håkansson, B, Meister
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The transcription factor STAT3 and aging: an intermediate medium

Biogerontology
Aging is a physiological/pathological process accompanied by progressive impairment of cellular function, leading to a variety of aging-related diseases. STAT3 is one of the core regulatory factors of aging. It is involved in body metabolism, development and senescence, cell apoptosis and so on.
Min, Shi, Honyu, Li, Runyu, Liang, Haiyan, Lin, Qiang, Tang   +4 more
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STAT3 correlates with stem cell-related transcription factors in cervical cancer

Journal of Huazhong University of Science and Technology [Medical Sciences], 2015
Cancer stem cells (CSCs) are considered responsible for the high recurrence rate in cervical carcinoma. It has been demonstrated that the signal transducer and activator of transcription 3 (STAT3) is involved in the oncogenesis and takes part in mediating the effects of maintaining stem cell phenotype and pluripotency by regulating the expression of ...
Hua, Wang, Hong-Bing, Cai, Lou-Lou, Chen, Wen-Jun, Zhao, Pan, Li, Zhi-Qiang, Wang, Zhen, Li   +6 more
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Role of the Leukemia-associated Transcription Factor STAT3 in Platelet Physiology

Leukemia & Lymphoma, 2002
Actinomycin D, a transcriptional inhibitor, was found to inhibit platelet potentiation by thrombopoietin (TPO), suggesting that TPO stimulation of platelets involves mitochondrial transcription. We sought to determine a possible role for leukemia-associated signal transducers and activators of transcription (STAT) proteins as mitochondrial ...
Alexei O, Vassilev, David R, Lorenz, Heather E, Tibbles, Fatih M, Uckun   +3 more
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