Primary Hepatic Solitary Fibrous Tumour: A Rare Mesenchymal Entity with Distinct Histopathologic and Molecular Features. [PDF]
Diagnostics (Basel)Gráczer A, Lantos T, Sejben A.
europepmc +1 more source
Investigating the mechanisms linking vitamin D to coronary artery disease: A mediating proteomics Mendelian randomisation study. [PDF]
Medicine (Baltimore)Xue Y, Cao S, Zhang L, Chen J, Ning A.
europepmc +1 more source
JAK-STAT signaling: molecular mechanism and targeted treatment in dento-maxillofacial abnormalities. [PDF]
Int J Oral SciHuang Z +6 more
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The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages [PDF]
Immunity, 2018 The molecular basis of signal-dependent transcriptional activation has been extensively studied in macrophage polarization, but our understanding remains limited regarding the molecular determinants of repression. Here we show that IL-4-activated STAT6 transcription factor is required for the direct transcriptional repression of a large number of genes
László Nagy +2 more
exaly +12 more sources
PTB-associated Splicing Factor (PSF) Functions as a Repressor of STAT6-mediated Igϵ Gene Transcription by Recruitment of HDAC1 [PDF]
Journal of Biological Chemistry, 2011 Regulation of transcription requires cooperation between sequence-specific transcription factors and numerous coregulatory proteins. In IL-4/IL-13 signaling several coactivators for STAT6 have been identified, but the molecular mechanisms of STAT6-mediated gene transcription are still not fully understood.
Lijie Dong +2 more
exaly +5 more sources
STAT6 Transcription Factor Is a Facilitator of the Nuclear Receptor PPARγ-Regulated Gene Expression in Macrophages and Dendritic Cells [PDF]
Immunity, 2010 Peroxisome proliferator-activated receptor γ (PPARγ) is a lipid-activated transcription factor regulating lipid metabolism and inflammatory response in macrophages and dendritic cells (DCs). These immune cells exposed to distinct inflammatory milieu show cell type specification as a result of altered gene expression. We demonstrate here a mechanism how
László Nagy +2 more
exaly +5 more sources
Severe allergic dysregulation due to a gain of function mutation in the transcription factor STAT6
Journal of Allergy and Clinical Immunology, 2023 Inborn errors of immunity have been implicated in causing immune dysregulation, including allergic diseases. STAT6 is a key regulator of allergic responses.This study sought to characterize a novel gain-of-function STAT6 mutation identified in a child with severe allergic manifestations.Whole-exome and targeted gene sequencing, lymphocyte ...
Talal Chatila
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Discrete Roles of STAT4 and STAT6 Transcription Factors in Tuning Epigenetic Modifications and Transcription during T Helper Cell Differentiation [PDF]
Immunity, 2010 Signal transducer and activator of transcription 4 (STAT4) and STAT6 are key factors in the specification of helper T cells; however, their direct roles in driving differentiation are not well understood. Using chromatin immunoprecipitation and massive parallel sequencing, we quantitated the full complement of STAT-bound genes, concurrently assessing ...
Weiqun Peng +2 more
exaly +3 more sources
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AbstractBACKGROUNDSignal transducer and activator of transcription (STAT)‐6 is a member of the STAT family of latent transcription factors. In this investigation, we examined STAT6 expression in clinical prostate cancer tissue specimen and determined its role in prostate cell proliferation and migration.METHODSSTAT6 expression in cell lines and tissues
Jamboor K Vishwanatha
exaly +3 more sources
Ectopic Expression of Activated Stat6 Induces the Expression of Th2-Specific Cytokines and Transcription Factors in Developing Th1 Cells [PDF]
Immunity, 1999 Stat6 is critical for IL-4-mediated Th2 cell development, but its molecular mechanism remains unclear. Here we constructed Stat6:ER, a Stat6-estrogen receptor fusion protein that can be activated by 4-hydroxy-tamoxifen, independently of IL-4 and endogenous Stat6.
Anne O'Garra, Naoko Arai
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