Results 11 to 20 of about 141,213 (164)

Statins and cancers [PDF]

Współczesna Onkologia, 2015
Statins (inhibitors of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase) are a group of drugs used to treat lipid disorders. They inhibit cholesterol synthesis at an early stage of the biosynthesis pathway, thus eliminating numerous metabolites involved in the cycle.
Stryjkowska-Góra, Aleksandra, Karczmarek-Borowska, Bożenna, Góra, Tomasz, Krawczak, Katarzyna   +3 more
openaire   +2 more sources

Statin use and the risk of hepatocellular carcinoma among patients with chronic hepatitis B: an emulated target trial using longitudinal nationwide population cohort data

BMC Gastroenterology, 2023
Background No randomized controlled trials have been completed to see whether statin can decrease hepatocellular carcinoma (HCC) risk in chronic hepatitis B (CHB) patients.
Dong Hyun Sinn, Danbee Kang, Yewan Park, Hyunsoo Kim, Yun Soo Hong, Juhee Cho, Geum-Youn Gwak   +6 more
doaj   +1 more source

Prescribing statin therapy in physically (in)active individuals vs prescribing physical activity in statin-treated patients: A four-scenario practical approach

Pharmacological Research, 2023
Statins are among the most commonly prescribed medications worldwide. Statin-associated muscle symptoms (SAMS) represent a frequent statin-related adverse effect associated with statin discontinuation and increased cardiovascular disease (CVD) events ...
Blanca Gavilán-Carrera, Alberto Soriano-Maldonado, Juan Diego Mediavilla-García, Carl J. Lavie, José Antonio Vargas-Hitos   +4 more
doaj   +1 more source

Comparative safety and efficacy of low- or moderate-intensity statin plus ezetimibe combination therapy and high-intensity statin monotherapy: A meta-analysis of randomized controlled studies

PLoS ONE, 2022
Statin is highly recommended for dyslipidemia to prevent atherosclerosis-related cardiovascular diseases and death. The aim of this study was to compare the efficacies and safeties of low/moderate-intensity statin plus ezetimibe combination therapy vs ...
Young-Mi Ah, Minseob Jeong, Hye Duck Choi   +2 more
doaj   +2 more sources

The Different Cardiovascular Outcomes Between Long-Term Efficacy of Hydrophilic and Lipophilic Statin Therapy in Both Asian Diabetic Sexes

Dose-Response, 2019
Purpose: To evaluate the long-term efficacy of hydrophilic and lipophilic statin therapy for cardiovascular outcomes in Asian diabetic patients. Method: Newly diagnosed cases of type 2 diabetes during the period from January 2000 to December 2011 were ...
Shang-Yi Li, Hsin-Hung Chen, Cheng-Li Lin, Su-Yin Yeh, Chia-Hung Kao   +4 more
doaj   +1 more source

National Assessment of Statin Therapy in Patients Hospitalized with Acute Myocardial Infarction: Insight from China PEACE-Retrospective AMI Study, 2001, 2006, 2011. [PDF]

PLoS ONE, 2016
BACKGROUND:Statin therapy is among the most effective treatments to improve short- and long-term mortality after acute myocardial infarction. The use of statin, and the intensity of their use, has not been described in acute myocardial infarction ...
Lihua Zhang, Jing Li, Xi Li, Khurram Nasir, Haibo Zhang, Yongjian Wu, Shuang Hu, Qing Wang, Nicholas S Downing, Nihar R Desai, Frederick A Masoudi, John A Spertus, Harlan M Krumholz, Lixin Jiang, China PEACE Collaborative Group   +14 more
doaj   +1 more source

Common Statin Intolerance Variants in ABCB1 and LILRB5 Show Synergistic Effects on Statin Response: An Observational Study Using Electronic Health Records

Frontiers in Genetics, 2021
Background: Statin intolerance impacts approximately 10% of statin users, with side effects ranging from mild myalgia to extreme intolerance resulting in myopathy and rhabdomyolysis.
Alaa’ Lutfi Melhem, Mehul Kumar Chourasia, Margherita Bigossi, Margherita Bigossi, Cyrielle Maroteau, Alasdair Taylor, Roberto Pola, Adem Y. Dawed, Aleksi Tornio, Aleksi Tornio, Colin N. A. Palmer, Moneeza K. Siddiqui   +11 more
doaj   +1 more source

Association of PCSK9 Inhibitor Initiation on Statin Adherence and Discontinuation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background PCSK9is (proprotein convertase subtilisin/kexin type 9 inhibitors) are well tolerated, potently lower cholesterol, and decrease cardiovascular events when added to statins.
Christopher LaFratte, Samuel K. Peasah, Yan Huang, Deanne Hall, Urvashi Patel, Chester B. Good   +5 more
doaj   +1 more source

Combination of Statin and Ezetimibe versus Statin Monotherapy on Cardiovascular Disease and Type 2 Diabetes Incidence among Adults with Impaired Fasting Glucose: a Propensity-Matched Nationwide Cohort Study

Journal of Lipid and Atherosclerosis, 2021
Objective We investigated the effects of statin-ezetimibe combination therapy compared with statin-only treatment on the hazard of incident type 2 diabetes (T2D), myocardial infarction (MI), and stroke among adults with impaired fasting glucose (IFG) in
You-Bin Lee, Bongsung Kim, Kyungdo Han, Jung A Kim, Eun Roh, So-hyeon Hong, Kyung Mook Choi, Sei Hyun Baik, Hye Jin Yoo   +8 more
doaj   +1 more source

UJI KLINIS TERBUKA EFEK TERAPI STATIN (SIMVASTATIN) TERHADAP KADAR HIGH SENSITIVITY C-REACTIVE PROTEIN (hs-CRP) PADA PENDERITA DIABETES TIPE 2

Saintika Medika, 2012
Latar Belakang. Diabetes mellitus (DM) mempunyai resiko kematian karena penyakit kardiovaskular dua sampai enam kali dibanding pasien tanpa DM. diketahui bahwa inflamasi berperan dalam pathogenesis aterosklerosis.
Isbandiyah .
doaj   +1 more source