Results 11 to 20 of about 154,404 (310)
Saudi Pharmaceutical Journal, 2023 Importance: Statins are drugs of choice in treating hyperlipidemia and preventing or reducing cardiovascular diseases. Purpose: Explore statins utilization and expenditure trends in the United States before and after the publication of the 2013 ACC/AHA ...
Amro Matyori +3 more
doaj +1 more source
Statin Hepatotoxicity: Is it a Real Concern?
Heart Views, 2011 Statins are the most effective and widely used drugs for treating dyslipidemia, a major risk factor for coronary heart disease. These are one of the safest hypolipidemic drugs but many patients are advised to discontinue statins for the fear of ...
Pranav Sikka, K K Saxena, Seema Kapoor
doaj +1 more source
Attempts to use statins in cancer therapy: An update
Tumor Biology, 2020 Although it could be speculated that almost everything has been said concerning the use of statins in cancer therapy, statins as anticancer drugs have both committed supporters and opponents, for whom the dispute about the legitimacy of statin use in ...
Lucyna Matusewicz +2 more
doaj +1 more source
Effects of Statins on Gut Microbiota (Microbiome) [PDF]
Reviews in Clinical Medicine, 2019 Statins are the inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A, which are extensively used to decrease the concentration of cholesterol in patients with hyperlipidemia.
Milad Ashrafizadeh, Zahra Ahmadi
doaj +1 more source
The pharmacological bases for repurposing statins in depression: a review of mechanistic studies
Translational Psychiatry, 2023 Statins are commonly prescribed medications widely investigated for their potential actions on the brain and mental health. Pre-clinical and clinical evidence suggests that statins may play a role in the treatment of depressive disorders, but only the ...
Riccardo De Giorgi +5 more
doaj +1 more source
Lipids in Health and Disease, 2021 Background Post-contrast acute kidney injury (PC-AKI) is a severe complication of coronary angiography (CAG) and percutaneous coronary intervention (PCI). Currently, the effect of statins on PC-AKI and its mechanism remains unclear.
Maoning Lin +8 more
doaj +1 more source
Prospects for the use of statins in antiviral therapy [PDF]
Клиническая микробиология и антимикробная химиотерапия, 2023 Inhibitors of hydroxymethylglutaryl-CoA reductase, in addition to suppressing cholesterol synthesis, have an antiviral effect. Clinical studies have shown antiviral efficacy of statins against COVID-19, HCV, HBV, RSV, HIV, influenza viruses.
Mustafin R.N.
doaj +1 more source
Metabolic Engineering Communications, 2015 Statins are inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase, the key enzyme in cholesterol biosynthesis. Their extensive use in treatment and prevention of cardiovascular diseases placed statins among the best selling drugs. Construction of
Ana Ley +2 more
doaj +1 more source
Pteridines, 2021 Psychiatric hospitalizations and emergency department (ED) visits are costly, stigmatizing, and often ineffective. Given the immune and kynurenine activation in bipolar disorder (BD) and schizophrenia, as well as the immune-modulatory effects of statins,
Postolache Teodor T. +7 more
doaj +1 more source
Statins interfere with the attachment of S. cerevisiae mtDNA to the inner mitochondrial membrane
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 The 3-hydroxy-3-methylglutaryl-CoA reductase, a key enzyme of the mevalonate pathway for the synthesis of cholesterol in mammals (ergosterol in fungi), is inhibited by statins, a class of cholesterol lowering drugs.
Angela Cirigliano +10 more
doaj +1 more source