Results 131 to 140 of about 110,517 (296)

Deep Galaxy Stellar Mass Functions As a Function of Star Formation Rate in the Virgo Cluster Environment

The Astrophysical Journal
We analyze deep ( M _* ≳ 10 ^7 M _⊙ ) galaxy stellar mass functions (SMFs) of the Virgo cluster using stellar masses derived as part of the Next Generation Virgo Survey. The total SMF has a slope of $\alpha =-1.3{5}_{-0.02}^{+0.02}$ , which is similar to
Cameron R. Morgan, Elizaveta Sazonova, Ian D. Roberts, Michael L. Balogh, Joel Roediger, Laura Ferrarese, Patrick Côté, Alessandro Boselli, Matteo Fossati, Jean-Charles Cuillandre, Stephen Gwyn   +10 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

LATIS: Constraints on the Galaxy–Halo Connection at z ∼ 2.5 from Galaxy–Galaxy and Galaxy–Lyα Clustering

The Astrophysical Journal
The connection between galaxies and dark matter halos is often quantified using the stellar mass–halo mass (SMHM) relation. Optical and near-infrared imaging surveys have led to a broadly consistent picture of the evolving SMHM relation based on ...
Andrew B. Newman, Mahdi Qezlou, Nima Chartab, Gwen C. Rudie, Guillermo A. Blanc, Simeon Bird, Andrew J. Benson, Daniel D. Kelson, Brian C. Lemaux   +8 more
doaj   +1 more source

Constraining the Star Formation Histories in Dark Matter Halos: I. Central Galaxies

, 2013
Using the self-consistent modeling of the conditional stellar mass functions across cosmic time by Yang et al. (2012), we make model predictions for the star formation histories (SFHs) of {\it central} galaxies in halos of different masses.
Bonaca, Ana, Bosch, Frank C. van den, Li, Shijie, Lu, Yi, Lu, Yu, Lu, Zhankui, Mo, H. J., Yang, Xiaohu   +7 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Rotation curves velocities obtained by warm low-density plasma simulating dark halos and “dark matter”

AIP Advances
The free electron model with Boltzmann statistics for spherical low-density plasmas is developed further, with asymptotic relations obtaining the density of electrons, mass densities, and the potentials of such plasmas.
Y. Ben-Aryeh
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

The Stellar Initial Mass Function in The Galactic Center [PDF]

, 2007
Massive stars define the upper limits of the star formation process, dominate the energetics of their local environs, and significantly affect the chemical evolution of galaxies. Their role in starburst galaxies and the early Universe is likely to be important, but we still do not know the maximum mass that a star can possess, i.e.``the upper mass ...
openaire   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source