Results 1 to 10 of about 12,666,103 (318)

Stem cell-based therapy for human diseases

Signal Transduction and Targeted Therapy, 2022
Recent advancements in stem cell technology open a new door for patients suffering from diseases and disorders that have yet to be treated. Stem cell-based therapy, including human pluripotent stem cells (hPSCs) and multipotent mesenchymal stem cells ...
Duc M. Hoang, P. Pham, Trung Q. Bach, Anh T L Ngo, Q. T. Nguyen, Trang T. K. Phan, Giang H. Nguyen, P. Le, Van T. Hoang, N. Forsyth, M. Heke, L. Nguyen   +11 more
semanticscholar   +1 more source

Single cell profiling of CD45+ spinal cord cells reveals microglial and B cell heterogeneity and crosstalk following spinal cord injury

Journal of Neuroinflammation, 2022
Background Immune cells play crucial roles after spinal cord injury (SCI). However, incomplete knowledge of immune contributions to injury and repair hinders development of SCI therapies.
Elizabeth S. Fisher, Matthew A. Amarante, Natasha Lowry, Steven Lotz, Farhad Farjood, Sally Temple, Caitlin E. Hill, Thomas R. Kiehl   +7 more
doaj   +1 more source

Wharton’s Jelly-Derived Mesenchymal Stem Cells with High Aurora Kinase A Expression Show Improved Proliferation, Migration, and Therapeutic Potential

Stem Cells International, 2022
Mesenchymal stem cells (MSCs) are effective therapeutic agents that contribute to tissue repair and regeneration by secreting various factors. However, donor-dependent variations in MSC proliferation and therapeutic potentials result in variable ...
Sun Jeong Kim, Sang Eon Park, Jang Bin Jeong, Shin Ji Oh, Alee Choi, Yun Hee Kim, Suk-joo Choi, Soo-young Oh, Gyu Ha Ryu, Hong Bae Jeon, Jong Wook Chang   +10 more
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GMP Compliant Production of a Cryopreserved Adipose-Derived Stromal Cell Product for Feasible and Allogeneic Clinical Use

Stem Cells International, 2022
The emerging field of advanced therapy medicinal products (ATMP) holds promise of treating a variety of diseases. Adipose-derived stromal cells (ASCs) are currently being marketed or tested as cell-based therapies in numerous clinical trials.
Mandana Haack-Sørensen, Ellen Mønsted Johansen, Lisbeth Drozd Højgaard, Jens Kastrup, Annette Ekblond   +4 more
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Targeting cancer stem cell pathways for cancer therapy

Signal Transduction and Targeted Therapy, 2020
Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been considered promising therapeutic targets for cancer therapy. These cells have self-renewal capacity and differentiation potential and contribute to multiple tumor ...
Liqun Yang, Pengfei Shi, Gaichao Zhao, Jie Xu, Wen Peng, Jiayi Zhang, Guanghui Zhang, Xiaowen Wang, Z. Dong, Fei Chen, H. Cui   +10 more
semanticscholar   +1 more source

The therapeutic applications of mesenchymal stromal cells from human perinatal tissues in autoimmune diseases

Stem Cell Research & Therapy, 2021
The autoimmune diseases are characterized by overactivation of immune cells, chronic inflammation, and immune response to self-antigens, leading to the damage and dysfunction of multiple organs.
Chao Yang, Mingjun Wu, Min You, Yu Chen, Maowen Luo, Qiang Chen   +5 more
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Liver development is restored by blastocyst complementation of HHEX knockout in mice and pigs

Stem Cell Research & Therapy, 2021
Background There are over 17,000 patients in the US waiting to receive liver transplants, and these numbers are increasing dramatically. Significant effort is being made to obtain functional hepatocytes and liver tissue that can for therapeutic use in ...
M. Ruiz-Estevez, A. T. Crane, P. Rodriguez-Villamil, F. L. Ongaratto, Yun You, A. R. Steevens, C. Hill, T. Goldsmith, D. A. Webster, L. Sherry, S. Lim, N. Denman, W. C. Low, D. F. Carlson, J. R. Dutton, C. J. Steer, O. Gafni   +16 more
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Intracellular role of IL-6 in mesenchymal stromal cell immunosuppression and proliferation

Scientific Reports, 2020
Interleukin (IL)-6 is a pleiotropic cytokine involved in the regulation of hematological and immune responses. IL-6 is secreted chiefly by stromal cells, but little is known about its precise role in the homeostasis of human mesenchymal stromal cells ...
Akaitz Dorronsoro, Valérie Lang, Izaskun Ferrin, Jon Fernández-Rueda, Lorea Zabaleta, Estibaliz Pérez-Ruiz, Pilar Sepúlveda, César Trigueros   +7 more
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Stem cell homing: From physiology to therapeutics

Stem Cells, 2020
Stem cell homing is a multistep endogenous physiologic process that is also used by exogenously administered hematopoietic stem and progenitor cells (HSPCs).
J. Liesveld, Naman Sharma, O. Aljitawi
semanticscholar   +1 more source

Assessment of established techniques to determine developmental and malignant potential of human pluripotent stem cells

Nature Communications, 2018
The International Stem Cell Initiative tests methods in a multisite study to detect pluripotency and teratoma formation (PluriTest, Embryoid Body and Teratoma methods) in human pluripotent stem cells.
The International Stem Cell Initiative
doaj   +1 more source