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Profiling the Secretome of Human Stem Cells from Dental Apical Papilla

Stem Cells and Development, 2016
Recent studies have shown that secretion of bioactive factors from mesenchymal stem cells (MSCs) plays a primary role in MSC-mediated therapy; especially for bone marrow-derived MSCs (BMSCs). MSCs from dental apical papilla (SCAPs) are involved in root development and may play a critical role in the formation of dentin and pulp.
Shi, Yu, Yuming, Zhao, Yushi, Ma, Lihong, Ge   +3 more
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Stem cells from apical papilla promote differentiation of human pluripotent stem cells towards retinal cells

Differentiation, 2018
Recently, we have found that human stem cells from apical papilla (SCAP) show a stromal cell-derived inducing activity (SDIA). To examine SDIA competence for retinal cells differentiation, we co-cultured SCAP with human pluripotent stem cells (hPSCs).
Hossein Baharvand, Leila Satarian, Fereshteh Karamali   +2 more
exaly   +3 more sources

Role of CPNE1 in Odontoblastic Differentiation of Rat Stem Cells from Apical Papilla

Advanced Biology, 2023
AbstractCPNE1 is a calcium‐dependent, phospholipid‐binding protein that is ubiquitously expressed in various tissues and organs. This study investigates the expression and localization of CPNE1 in tooth germ development and the role of CPNE1 in odontoblastic differentiation.
Xi Lu, Han Xie, Yanqin Ju, Yunyu Fu, Shangfeng Liu, Shouliang Zhao   +5 more
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[Inhibition of autophagy suppresses osteogenic differentiation of stem cells from apical papilla]. [PDF]

Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2019
To investigate the effects of autophagy on osteogenic differentiation of stem cells from the apical papilla (SCAPs) in the presence of tumor necrosis factor-α (TNF-α) stimulation in vitro.SCAPs treated with TNF-α (0, 5, and 10 ng/mL) with or without 5 mmol/L 3-MA were examined for the expression of autophagy marker LC3-Ⅱ using Western blotting.
Ying, Huang, Huacui, Xiong, Ke, Chen, Xiaobin, Zhu, Xiaoping, Yin, Yun, Liang, Wei, Luo, Qiyin, Lei   +7 more
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Molecular Biological Comparison of Dental Pulp- and Apical Papilla-Derived Stem Cells [PDF]

International Journal of Molecular Sciences, 2022
Both the dental pulp and the apical papilla represent a promising source of mesenchymal stem cells for regenerative endodontic protocols. The aim of this study was to outline molecular biological conformities and differences between dental pulp stem ...
Matthias Widbiller, Wolfgang Buchalla, Christoph Moehle   +2 more
exaly   +2 more sources

Overexpression of ephrinB2 in stem cells from apical papilla accelerates angiogenesis

Oral Diseases, 2019
AbstractObjectivesWe aimed to accelerate angiogenesis in pulp regeneration by modulating ephrinB2 expression in stem cells from apical papilla (SCAPs).Materials and MethodsStem cells from apical papilla were transducted with ephrinB2‐lentiviral expression vector (ephrinB2‐SCAPs) in experimental group and green fluorescent protein (GFP‐SCAPs) in control
Changyong Yuan, Penglai Wang, Shaoyue Zhu, Zongxiang Liu, Wen Wang, Tengyu Geng, Waruna Lakmal Dissanayaka, Lijian Jin, Chengfei Zhang   +8 more
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Effects of Lipopolysaccharide on the Proliferation and Osteogenic Differentiation of Stem Cells from the Apical Papilla

Journal of Endodontics, 2017
Stem cells from the apical papilla (SCAPs) were suggested as the stem cell source in regenerative endodontic procedures. However, bone and/or cementum-like structure were observed in root canals. Lipopolysaccharide (LPS) in infected root canals might alter SCAPs' osteogenic differentiation pattern.
Veera, Lertchirakarn, Panuroot, Aguilar
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Effect of cryopreservation on biological and immunological properties of stem cells from apical papilla

Journal of Cellular Physiology, 2010
AbstractStem cells from apical papilla (SCAP) are a novel population of multipotent stem cells that, although similar to dental pulp stem cells, are a discrete source of dental stem cells. SCAP have potential roles in root development, apexogenesis, pulp/dentin regeneration, and bioroot engineering.
Gang, Ding, Wei, Wang, Yi, Liu, Yunqing, An, Chunmei, Zhang, Songtao, Shi, Songlin, Wang   +6 more
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Engineering a Novel Stem Cells from Apical Papilla-Macrophages Organoid for Regenerative Endodontics

Journal of Endodontics, 2022
A 3-dimensional (3D) tissue construct with a heterogeneous cell population is critical to understand the interactions between immune cells and stem cells from the apical papilla (SCAPs) in the periapical region for developing treatment strategies in regenerative endodontics.
Fang-Chi Li, Alireza Shahin-Shamsabadi, P. Ravi Selvaganapathy, Anil Kishen   +3 more
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Interactions of Neuronally Induced Stem Cells from Apical Papilla Spheres, Stems Cells from Apical Papilla, and Human Umbilical Vascular Endothelial Cells on Vasculogenesis and Neurogenesis

Journal of Endodontics
Stem cell-based dental pulp regeneration has been extensively studied, mainly focusing on exploiting dental stem cells' osteogenic and angiogenic potentials. Dental stem cells' neurogenic role is often overlooked. Stem cells from apical papilla (SCAPs), originating from the neural crest and capable of sphere formation, display potent neurogenic ...
Mohammed S. Basabrain, Jialin Zhong, Junqing Liu, Yuchen Zhang, Mohamed Mahmoud Abdalla, Chengfei Zhang   +5 more
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